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Exercise after chemo: new trial tests if running and walking can keep colorectal cancer at bay

NCT ID NCT03822572

Disease control Sponsor: Austrian Breast & Colorectal Cancer Study Group Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether a structured endurance exercise program, like walking or cycling, after finishing chemotherapy can help prevent colorectal cancer from returning. About 92 patients who have completed adjuvant chemotherapy will be randomly assigned to either an exercise program or their usual physical activity. Researchers will track how long they live without cancer coming back and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
endurance exercise program
What this could lead to
If it works, this could show that a structured exercise program after chemotherapy helps prevent cancer from coming back and improves survival.
What could go wrong
This is a small, early-stage trial with only 92 participants, so results may not apply to everyone. Previous studies on exercise after chemotherapy have had mixed results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

Feb 2019

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * completely resected, histologically confirmed adenocarcinoma of the colon or rectum * patients, who have completed adjuvant chemotherapy 4-16 weeks prior to randomization * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Age ≥18 years * adequate hematologic functions \<=28d prior to randomization * able to perform endurance exercise according to protocol * ability to perform ergometry in order to assess physical capability at the discretion of the investigator * signed informed consent prior to randomization Exclusion Criteria: * significant comorbid conditions precluding participation in a physical activity program (investigators decision) * disabled patients unable to participate in the physical activity program * Regular (3-times a week) vigorous physical activity of \>150 minutes (type of physical activity: bicycling, cross walking (cross trainer), jogging, walking at a brisk pace, nordic walking, cross country skiing) within the last year before diagnosis of colorectal cancer * patients unwilling to complete endurance exercise or complete all questionnaires related to the study * past or current history of other malignant neoplasms other than colorectal cancer in the last 5 years except basal cell carcinoma of the skin and/or in situ carcinoma of the cervix * clinically significant cardiovascular disease * left bundle branch block * current study with chemotherapy or radiation * current pregnancy or plans to become pregnant within the next 3 years

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal carcinoma

Contacts and locations

Locations

  • BKH Kufstein

    Kufstein, Tyrol, 6330, Austria

  • Hospital BHS Linz, Coop. Study Group

    Linz, Upper Austria, 4010, Austria

  • KH St. Josef Braunau

    Braunau am Inn, Upper Austria, 5280, Austria

  • Kepler Universitätsklinikum Linz

    Linz, Upper Austria, 4020, Austria

  • Klinikum Wels-Grieskirchen

    Wels, Upper Austria, 4600, Austria

  • LKH Salzburg-PMU, UNiv. KLinik f. Innere Med III

    Salzburg, State of Salzburg, 5020, Austria

  • Med. Univ. Graz

    Graz, Styria, 8036, Austria

  • Pyhrn-Eisenwurzen Klinikum Steyr

    Steyr, Upper Austria, 4400, Austria

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