New drug aims to boost immune system against tough cancers

NCT ID NCT06882746

Recruiting now Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests an experimental drug called BI 765049 in adults with advanced colorectal, stomach, or pancreatic cancer that cannot be removed by surgery or has spread. The main goal is to find the highest dose people can tolerate and to see if the drug helps the immune system fight the cancer. About 135 participants will receive the drug at least every three weeks and be closely monitored for side effects and tumor response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BI 765049 (an experimental immunotherapy drug given by injection or infusion)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced colorectal, stomach, or pancreatic cancer who have run out of standard options.
What could go wrong: This is a very early (Phase 1) trial with only 135 participants, so the drug may not work or may cause severe side effects. The cancers studied are hard to treat, and success is far from guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal carcinoma colorectal neoplasm gastric carcinoma gastric neoplasm pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CARCINOMA GASTRIC CARCINOMA PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Locations

Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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