New Antibody-Drug conjugate targets Hard-to-Treat cancers
NCT ID NCT06723236
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests MGC028, a drug that delivers a cancer-killing agent directly to tumor cells. About 124 adults with advanced lung, bile duct, pancreatic, or colorectal cancers that have stopped responding to standard treatments will receive the drug every three weeks. The main goals are to find safe doses and see if the drug can shrink or stabilize tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- MGC028 (an antibody-drug conjugate targeting ADAM9)
- What this could lead to
- If it works, this could point toward a new treatment option for several advanced solid tumors that have not responded to standard therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 124 participants, so the drug may not prove safe or effective. Side effects could be significant, and the cancer may still progress.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Dana Farber/Harvard Cancer Center
RECRUITINGBoston, Massachusetts, 02115, United States
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Icahn School of Medicine at Mt. Sinai
RECRUITINGNew York, New York, 10029, United States
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Mass General Brigham
RECRUITINGBoston, Massachusetts, 02114, United States
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South Texas Accelerated Research Therapeutics (START) Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
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South Texas Accelerated Research Therapeutics (START) Mountain Region
RECRUITINGWest Valley City, Utah, 84119, United States
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South Texas Accelerated Research Therapeutics (START) San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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UCSF - Helen Diller Family Cancer Center
RECRUITINGSan Francisco, California, 94115, United States
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