New smart chemo targets tumors, spares healthy tissue
NCT ID NCT07454642
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests a new drug called AVA6103 in 174 people with advanced solid tumors (like pancreatic, stomach, or lung cancer) that have not responded to standard treatments. The drug is designed to activate only inside tumors, potentially killing cancer cells while reducing harm to healthy cells. The main goals are to check safety and find the right dose, with initial signs of effectiveness also being measured.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AVA6103, a targeted chemotherapy that activates inside tumors
- What this could lead to
- If it works, this could point toward a new treatment option for several advanced cancers that have stopped responding to standard therapies.
- What could go wrong
- This is a very early Phase 1 trial, so the drug may not be effective or could have serious side effects. It is only tested in a small number of people with specific tumor types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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NEXT Oncology
RECRUITINGIrving, Texas, 75039, United States
-
NEXT Oncology Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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START Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
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