Chemo after surgery may delay return of advanced colon cancer

NCT ID NCT05008809

Recruiting now Disease control Sponsor: Dominik Paul Modest Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether giving chemotherapy after all visible tumors have been removed or destroyed can delay cancer progression in people with metastatic colorectal cancer. About 507 participants will be randomly assigned to receive either chemotherapy (mFOLFOX6 or mFOLFOXIRI) or active surveillance (no treatment). The goal is to see if the chemo improves how long the cancer stays away.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: chemotherapy (mFOLFOX6 or mFOLFOXIRI)
What this could lead to: If it works, this could show that giving chemotherapy after removing all visible tumors helps keep the cancer from coming back longer than just watching and waiting.
What could go wrong: This is a large Phase 3 trial, but chemotherapy has significant side effects, and it is not yet known if the benefits outweigh the risks compared to surveillance alone.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Charité Universitätsmedizin Berlin
RECRUITING

Berlin, 13353, Germany
DIAK Klinikum Schwäbisch Hall
RECRUITING

Schwäbisch Hall, Germany
DONAUISAR Klinikum Deggendorf
RECRUITING

Deggendorf, Germany
Diakonie-Krankenhaus Bremen
WITHDRAWN

Bremen, Germany
Ernst von Bergmann Klinikum Potsdam
RECRUITING

Potsdam, Germany
Friedrich-Ebert-Krankenhaus Neumünster
RECRUITING

Neumünster, Germany
Gemeinschaftspraxis Münster
RECRUITING

Münster, Germany
Gemeinschaftspraxis Würzburg
RECRUITING

Würzburg, Germany
Gemeinschaftspraxis internistische Onkologie Fürth
RECRUITING

Fürth, Germany
Helios Klinikum Bad Saarow
RECRUITING

Bad Saarow, Germany
Helios Klinikum Emil von Behring
RECRUITING

Berlin, Germany
Johannes Wesling Klinikum Minden
RECRUITING

Minden, Germany
Johanniterkrankenhaus Bonn
RECRUITING

Bonn, Germany
KHNW Frankfurt
RECRUITING

Frankfurt, Germany
Kliniken Essen-Mitte
RECRUITING

Essen, Germany
Kliniken Maria Hilf Mönchengladbach
WITHDRAWN

Mönchengladbach, Germany
Kliniken der Satdt Köln
RECRUITING

Cologne, Germany
Klinikum Bayreuth
RECRUITING

Bayreuth, Germany
Klinikum Chemnitz
RECRUITING

Chemnitz, Germany
Klinikum Darmstadt
RECRUITING

Darmstadt, Germany
Klinikum Ingolstadt GmbH
WITHDRAWN

Ingolstadt, Germany
Klinikum Landshut
RECRUITING

Landshut, Germany
Klinikum Leverkusen
RECRUITING

Leverkusen, Germany
Klinikum Lippe
RECRUITING

Lippe, Germany
Klinikum Ludwigsburg
RECRUITING

Ludwigsburg, Germany
Klinikum Magdeburg
RECRUITING

Magdeburg, Germany
Klinikum Nürnberg
RECRUITING

Nuremberg, Germany
Klinikum Passau
RECRUITING

Passau, Germany
Klinikum St. Marien Amberg
RECRUITING

Amberg, Germany
Klinikum Stuttgart
RECRUITING

Stuttgart, Germany
Klinikum Wetzlar
RECRUITING

Wetzlar, Germany
Klinikum der Universität München
RECRUITING

München, Germany
Klinikum rechts der Isar TU München
RECRUITING

München, Germany
Krankenhaus Barmherzige Brüder Regensburg
RECRUITING

Regensburg, Germany
Krankenhaus der Barmherzigen Brüder Trier
RECRUITING

Trier, Germany
Kreiskliniken Reutlingen
RECRUITING

Reutlingen, Germany
Lukaskrankenhaus Neuss
RECRUITING

Neuss, Germany
MVZ Onkologischer Schwerpunkt am Oskar-Helene-Heim
RECRUITING

Berlin, Germany
Marienhospital Stuttgart
WITHDRAWN

Stuttgart, Germany
Marienkrankenhaus Siegen
RECRUITING

Siegen, Germany
Markus-Krankenhaus Frankfurt
RECRUITING

Frankfurt, Germany
Mathias Spital Rheine
RECRUITING

Rheine, Germany
Medizinische Hochschule Hannover
RECRUITING

Hanover, Germany
München Klinik Bogenhausen
RECRUITING

München, Germany
München Klinik Neuperlach
RECRUITING

München, Germany
Niels-Stensen Kliniken Georgsmarienhütte
RECRUITING

Georgsmarienhütte, Germany
OnkoNet Marburg GmbH
RECRUITING

Marburg, Germany
Onkologische-Gemeinschaftspraxis Dresden
RECRUITING

Dresden, Germany
Onkologisches Zentrum Wolfsburg-Helmstedt
WITHDRAWN

Wolfsburg, Germany
Onkozentrum Dresden
RECRUITING

Dresden, Germany
Petrus-Krankenhaus Wuppertal
RECRUITING

Wuppertal, Germany
Philipps-Universität Marburg
RECRUITING

Marburg, Germany
Pi.Tri-Studien GmbH Offenburg
WITHDRAWN

Offenburg, Germany
Praxis Hämatologie Onkologie Gießen
RECRUITING

Giessen, Germany
RoMed Klinikum Rosenheim
RECRUITING

Rosenheim, Germany
Schwerpunktpraxis Penzberg
RECRUITING

Penzberg, Germany
St. Anna Hospital Herne
RECRUITING

Herne, Germany
St. Josef-Hospital Bochum
RECRUITING

Bochum, Germany
Studienzentrum Onkologie Ravensburg
RECRUITING

Ravensburg, Germany
Studienzentrum UnterEms Leer
ACTIVE_NOT_RECRUITING

Leer, Germany
Städtisches Klinikum Dessau
RECRUITING

Dessau, Germany
Universitätsklinikum Düsseldorf
RECRUITING

Düsseldorf, Germany
Universitätsklinikum Essen
RECRUITING

Essen, Germany
Universitätsklinikum Frankfurt
RECRUITING

Frankfurt, Germany
Universitätsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, Germany
Universitätsklinikum Halle
RECRUITING

Halle, Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, Germany
Universitätsklinikum Jena
RECRUITING

Jena, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Germany
Universitätsklinikum Münster
RECRUITING

Münster, Germany
Universitätsklinikum Regensburg
RECRUITING

Regensburg, Germany
Universitätsklinikum Ulm
RECRUITING

Ulm, Germany
Universitätsklinikum des Saarlandes
RECRUITING

Homburg, Germany
Universitätsmedizin Göttingen
RECRUITING

Göttingen, Germany
Universitätsmedizin Mainz
RECRUITING

Mainz, Germany
Universitätsmedizin Rostock
RECRUITING

Rostock, Germany
VK&K Studien Landshut
RECRUITING

Landshut, Germany
Vivantes Klinikum Spandau Berlin
RECRUITING

Berlin, Germany
Vivantes Klinikum am Urban Berlin
RECRUITING

Berlin, Germany

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