New drug combo takes on tough cancers in early trial

NCT ID NCT06764771

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This early-stage trial is testing an experimental drug called BMS-986488, alone or combined with other cancer drugs, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. About 437 adults with certain cancers like kidney, lung, or colorectal cancer are taking part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BMS-986488 (an experimental drug), sometimes combined with adagrasib, cetuximab, or nivolumab
What this could lead to: If it works, this could point toward a new treatment option for certain advanced cancers that are hard to treat.
What could go wrong: This is an early Phase 1 trial focused on safety, not yet on effectiveness. It is small and may not lead to a proven therapy. Side effects are unknown and could be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ADVANCED MALIGNANT TUMORS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cancer colorectal cancer colorectal neoplasm neoplasm non-small cell lung carcinoma nonpapillary renal cell carcinoma ovarian clear cell tumor pancreatic ductal adenocarcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MALIGNANT TUMORS

Contacts and locations

Locations

BC Cancer Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
RECRUITING

Québec, Quebec, G1J 1Z4, Canada
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Local Institution - 0015
NOT_YET_RECRUITING

Montreal, Quebec, H2X 0A9, Canada
Local Institution - 0020
ACTIVE_NOT_RECRUITING

Allentown, Pennsylvania, 18103, United States
Local Institution - 0025
WITHDRAWN

Dallas, Texas, 75390, United States
Local Institution - 0031
ACTIVE_NOT_RECRUITING

Brisbane, Queensland, 4029, Australia
The West Clinic, PLLC dba West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.