Tailored chemo doses aim to cut severe side effects in digestive cancer patients
NCT ID NCT06475352
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adjusting chemotherapy doses based on a patient's DPD enzyme activity can reduce severe side effects in people with digestive cancers. About 400 participants with DPD deficiency will receive lower doses of fluoropyrimidine chemo (with oxaliplatin) and be monitored for toxicity. The goal is to find the safest effective dose for this group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fluoropyrimidine chemotherapy (5-fluorouracil or capecitabine) with oxaliplatin
What this could lead to
If successful, this could establish safer dosing guidelines for DPD-deficient patients, reducing severe side effects from standard chemotherapy.
What could go wrong
This is a Phase 2 trial with 400 participants, so results are still early. The dose adjustments may not work for all patients or cancer types.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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CH Aunay Bayeux
RECRUITINGBayeux, 14400, France
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CH Cote Basque
RECRUITINGBayonne, 64109, France
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CH de Saint Malo
RECRUITINGSt-Malo, 35403, France
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CHRU Nancy
NOT_YET_RECRUITINGVandœuvre-lès-Nancy, France
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CHU Amiens
RECRUITINGAmiens, 50054, France
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CHU Besançon
RECRUITINGBesançon, 25000, France
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CHU Bordeaux
RECRUITINGPessac, 33600, France
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CHU Clermont Ferrand
NOT_YET_RECRUITINGClermont-Ferrand, 63003, France
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CHU Dijon
RECRUITINGDijon, 21079, France
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CHU Dupuytren
RECRUITINGLimoges, 87042, France
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CHU Poitiers
RECRUITINGPoitiers, 86000, France
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CHU Rouen - Hopital Charles Nicoles
RECRUITINGRouen, France
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CHU d'Orléans
RECRUITINGOrléans, 45067, France
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CHU de Toulouse
RECRUITINGToulouse, 31059, France
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Centre Antoine Lacassagne
RECRUITINGNice, 06189, France
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Centre Eugene Marquis
NOT_YET_RECRUITINGRennes, France
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Centre François Baclesse
RECRUITINGCaen, 14000, France
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Centre Léon Bérard
RECRUITINGLyon, 69373, France
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Centre Oscar Lambret
RECRUITINGLille, France
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GH Diaconesses Croix St Simon
RECRUITINGParis, 75020, France
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GH Mutualiste de Grenoble
RECRUITINGGrenoble, 38028, France
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Grand Hopital de l'Est Francilien
RECRUITINGMeaux, 77100, France
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Gustave Roussy Cancer Campus
RECRUITINGVillejuif, 94805, France
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Hopital Beaujon
RECRUITINGClichy, 92110, France
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Hopital Bretonneau
RECRUITINGTours, 37044, France
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Hopital Européen Georges Pompidou
RECRUITINGParis, France
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Hopital Henri Mondor
RECRUITINGAurillac, France
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Hopital Henri Mondor
RECRUITINGCréteil, 94010, France
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Hopital Nord Franche Comté - Site du Mittan
RECRUITINGMontbéliard, 25200, France
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Hopital Privé Drome-Ardeche
RECRUITINGGuilherand-Granges, 07500, France
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Hopital Privé Jean Mermoz
RECRUITINGLyon, 69008, France
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Hopital Robert Debré
RECRUITINGReims, 51100, France
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Hopital Saint Antoine
RECRUITINGParis, 75012, France
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Hopital Saint Louis
RECRUITINGParis, 75010, France
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Hospices Civiles de Lyon
RECRUITINGPierre-Bénite, 69495, France
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Infirmerie Protestante
NOT_YET_RECRUITINGCaluire-et-Cuire, France
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Institut Curie
RECRUITINGParis, 75005, France
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Institut Jean Godinot
WITHDRAWNReims, 51100, France
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Institut du Cancer Avignon Provence
RECRUITINGAvignon, 84000, France
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Institut du Cancer de Strasbourg
RECRUITINGStrasbourg, 67033, France
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Polyclinique du Parc - Centre d'Oncologie Maurice Tubiana
RECRUITINGCaen, 14000, France
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