Could lidocaine or dexamethasone improve colon cancer surgery recovery?

NCT ID NCT07432399

Recruiting now Knowledge-focused Sponsor: Institute of Oncology Ljubljana Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial is testing whether giving lidocaine or high-dose dexamethasone during colon cancer surgery can improve the body's immune response and help patients recover better. 100 adults scheduled for colon cancer surgery will be randomly assigned to receive one of the two drugs or a placebo. The study measures inflammatory markers and pain levels to see if either drug reduces complications and speeds up recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lidocaine and dexamethasone
What this could lead to: If successful, this could point toward a simple, low-cost way to improve recovery and reduce complications after colon cancer surgery.
What could go wrong: This is an early Phase 2 trial with only 100 participants, so results may not apply to all patients. The study measures immune markers, not long-term outcomes, so benefits may not translate to real-world recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CANCER COLORECTAL CANCER PERIOPERATIVE IMMUNE RESPONSE

Contacts and locations

Locations

Institute of Oncology Ljubljana
RECRUITING

Ljubljana, 1000, Slovenia

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