COLORECTAL CANCER

This study tested whether combining two immunotherapy drugs (atezolizumab and bevacizumab) could shrink tumors in people with advanced colorectal cancer that had stopped responding to standard chemotherapy. The trial enrolled 46 adults whose cancer had a specific genetic signatur…

This early-stage study tested two different drug combinations (TNO155 with either spartalizumab or ribociclib) in adults with advanced solid tumors, including lung, head and neck, and colorectal cancers. The main goal was to find safe doses and understand side effects, not to cur…

This study tested whether adding an experimental drug called SOT101 to an existing immunotherapy (pembrolizumab) could help control advanced cancers that had stopped responding to other treatments. It involved 166 adults with specific advanced solid tumors, including lung, colore…

This study tested whether adding an experimental drug called ompenaclid to standard chemotherapy could help control advanced colorectal cancer that had worsened after initial treatment. The trial involved 76 patients with a specific genetic mutation (RAS mutant) in their cancer. …

This study tested a new drug combination (NUFIRI-bev) against the standard treatment (FOLFIRI-bev) for people with advanced colorectal cancer that had spread and could not be removed by surgery. The goal was to see if the new combination was more effective and safer for patients …

This early-stage study tested a personalized cancer treatment that modifies a patient's own immune cells to recognize and attack their specific tumor mutations. The trial enrolled 8 adults with advanced solid tumors (including ovarian, lung, pancreatic, and colorectal cancers) wh…

This was an early-stage study testing a new drug called BDC-3042, both by itself and combined with an existing immunotherapy (cemiplimab), in people with advanced cancers that had stopped responding to standard treatments. The main goals were to find safe doses and see if the tre…

This early-stage study tested a new oral medication called IK-595 in adults with advanced solid tumors that have specific genetic changes (RAS or RAF mutations) and no remaining standard treatment options. The main goals were to find a safe dose, see how the body processes the dr…

This study tested an experimental drug called DAY101 (tovorafenib) in people aged 12 and older with advanced solid tumors that had stopped responding to other treatments. The goal was to see if the drug could shrink or control tumors that have specific genetic changes. The trial …

This study tested a new type of vaccine, EO2040, combined with an immunotherapy drug (nivolumab). It aimed to prevent colorectal cancer from returning in patients who had finished standard treatment but still had tiny traces of cancer DNA in their blood. The trial was terminated …

This early-stage study tested a new drug called TAK-186 in adults with advanced cancers of the head & neck, lung, or colon that could not be removed by surgery. The main goal was to find a safe dose and understand the drug's side effects. Researchers also looked for early signs t…

This study compared CT colonography (a special type of CT scan) to traditional colonoscopy for finding advanced polyps in people at high risk for colorectal cancer. Researchers wanted to see which test patients were more willing to complete and which was more effective at finding…

This study tested whether showing educational videos about colon cancer screening options could encourage more people to get screened. It involved over 1,800 adults who were due for their first screening. The trial was stopped early, so the main results about whether the videos w…

This study tested a brief phone-based therapy to help patients and their partners cope with the emotional trauma of receiving news that their cancer is advanced and incurable. The therapy combined deep breathing exercises with a technique to help people structure their traumatic …

This study tested if using a secure website for patients to regularly report their symptoms during chemotherapy could improve their quality of life. It compared this online system, which alerted nurses to worsening symptoms, against standard doctor's visits. The goal was to manag…

This study aimed to find new ways to predict how colorectal cancer will progress by looking at tiny particles called exosomes in the blood. Researchers analyzed stored blood samples from 172 patients to see if specific markers within these particles could indicate a patient's sur…

This study created a registry to learn about the long-term health and wellbeing of young adults who survived cancer. It aimed to measure their levels of anxiety, depression, social support, and financial stress over time. Participants completed online surveys every 6-12 months to…