COLORECTAL CANCER

This study tested a personalized treatment where a patient's own immune cells were modified in a lab to recognize and attack unique markers on their cancer cells. It involved 8 people with advanced solid tumors like lung, pancreatic, or ovarian cancer that had stopped responding …

This study tested a new drug (SOT101) combined with pembrolizumab in 166 people with advanced solid tumors like lung, colon, and ovarian cancer. The goal was to see if the combination could shrink tumors. The study was stopped early, and participants were expected to need ongoing…

This early-phase study tested a new medicine called PF-07921585, given alone or with another drug (sasanlimab), in adults with advanced solid tumors like lung, bladder, kidney, skin, head and neck, or colorectal cancer. The goal was to check safety and how the body handles the dr…

This study tested a new drug called TAK-186 in adults with advanced head and neck, lung, or colorectal cancer that could not be removed by surgery. The main goals were to check for side effects and find the best dose. The trial was stopped early, but the results help researchers …

This early-stage study tested a new drug called BDC-3042, alone or with another drug (cemiplimab), in 17 people with advanced cancers such as breast, kidney, ovarian, head and neck, colorectal, lung, and skin cancer. The main goal was to check safety and find the right dose. The …

This study tested a drug called tovorafenib in people aged 12 and older whose cancers had returned or worsened and had certain gene changes (MAPK pathway). The goal was to see if the drug could shrink tumors. The study was stopped early, so results are limited.

This study tested a new vaccine (EO2040) made from gut bacteria, combined with the immunotherapy drug nivolumab, in people with colorectal cancer who had signs of remaining disease after standard treatment. The goal was to see if the combination could clear cancer DNA from the bl…

This early-phase study tested an experimental oral drug called IK-595 in 75 adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have specific RAS or RAF gene mutations. The goal was to check safety, find the right dose, and see if it shrinks tumor…

This study tested a combination of two drugs (atezolizumab and bevacizumab) in 46 people with advanced colorectal cancer that had stopped responding to standard chemotherapy and had a specific genetic signature called MSI-like. The goal was to see if the combination could shrink …

This study tested three different doses of an experimental drug called AUR 109 in 29 adults with advanced colorectal, ovarian, or kidney cancer who had already tried at least two other treatments. The goal was to see if the drug could shrink tumors and to check its safety. Howeve…

This study tested a new drug combination (NUFIRI-bev) against a standard treatment (FOLFIRI-bev) for people with advanced colorectal cancer that had already been treated. The goal was to see if the new combo worked better at controlling the cancer. The trial was stopped early, so…

This study tested whether adding the experimental drug ompenaclid to standard chemotherapy could shrink tumors in people with advanced colorectal cancer that has a specific genetic change (RAS mutation). The study was stopped early, so results are limited. It involved 76 adults w…

This early-stage trial tested a new drug (TNO155) combined with either spartalizumab or ribociclib in adults with advanced solid tumors like lung, head and neck, and colorectal cancers. The main goal was to check safety and find the right dose. The study was terminated, so result…

This early study tested a special dye called VGT-309 that makes colorectal tumors glow during a colonoscopy. The goal was to see if it is safe and helps doctors find cancer more easily. The study was stopped early and included 9 adults with colorectal cancer.

This study looked at whether people at high risk for colorectal cancer prefer a CT scan (virtual colonoscopy) or a traditional colonoscopy to find advanced polyps. It involved 39 adults aged 18 to 80 with a personal or family history of colorectal cancer or advanced polyps. The m…

This study tested whether a shorter, less expensive liver MRI using one contrast agent works as well as the standard agent for finding colorectal cancer that has spread to the liver. Ten adults with suspected liver metastases were enrolled. The goal was to see if the faster metho…

This study tested a special technique that combines organizing traumatic memories with slow, deep breathing to reduce PTSD symptoms in people with advanced cancer and their partners. The goal was to see if this approach could lower stress, inflammation, and possibly improve survi…

This study looked at whether giving patients branched-chain amino acids (a type of protein building block) before colorectal cancer surgery could reduce the common problem of high blood sugar after the operation. The study planned to enroll 79 adults aged 50-80 with colorectal ca…

This study aimed to see if a short video explaining different colorectal cancer screening options (like colonoscopy, FIT, and Cologuard) could help people who had never been screened decide to get tested. About 1,800 adults aged 45 to 70 were going to take part, but the study was…

This study looked at 289 people with early-onset breast, ovarian, colorectal, or pediatric cancers, plus those with multiple tumors. Researchers used a special test to check 200 genes for inherited mutations that standard tests might miss. The goal was to better understand why th…

This study looked at whether tiny particles called exosomes, found in the blood of colorectal cancer patients, can be used as biomarkers to predict survival and disease progression. Researchers analyzed blood samples from 172 participants to see if the number, size, and contents …

This study created a registry for people who survived cancer as young adults (ages 18-39). Researchers wanted to understand their levels of depression, anxiety, social support, and financial stress. Participants filled out online surveys every 6 to 12 months. The registry also he…

This study aimed to see if using an electronic system to track symptoms could improve quality of life for people with early-stage breast or colorectal cancer receiving chemotherapy. Only 8 participants were enrolled before the trial was stopped early. The main goal was to measure…