COLORECTAL CANCER

This early-stage trial is testing a new drug called TB511, both by itself and in combination with the immunotherapy drug pembrolizumab (Keytruda). It aims to find a safe dose and see if it can shrink tumors in people with advanced solid cancers, including lung, prostate, colorect…

This study is testing whether adding two drugs (pirfenidone and sintilimab) to standard chemotherapy can better shrink tumors in patients with colorectal cancer that has spread to the lining of the abdomen. It will enroll 30 patients who are about to start their first treatment. …

This is an early-stage safety study testing a new two-part cancer vaccine strategy. It is for adults with advanced colorectal or small bowel cancer that has continued to grow despite standard treatments. The main goal is to find a safe dose and see if the body's immune system rea…

This study is for people who have had surgery to remove colorectal cancer that spread to their liver. It tests a method of delivering chemotherapy directly into the liver's blood supply to try to prevent the cancer from coming back. The goal is to see if this targeted approach wo…

This study compares two different drug combinations for people with advanced colorectal cancer that has spread and has a specific genetic change (RAS mutation). About 224 patients whose cancer has worsened after initial treatment will receive either a newer drug (fruquintinib) pl…

This early-stage study is testing the safety and initial effectiveness of a new two-part treatment for advanced colorectal cancer that has spread to the liver and hasn't responded to standard therapies. About 25-30 patients will receive injections of a genetically engineered viru…

This study is testing a new drug called AMT-676 in combination with standard chemotherapy drugs for people with advanced colorectal cancer that cannot be surgically removed. The main goals are to see if the combination is safe, what side effects occur, and whether it helps shrink…

This study tests whether adding newer immunotherapy drugs to standard chemotherapy before surgery works better for rectal cancer that hasn't spread. Researchers will compare three different drug combinations in 66 patients to see which helps shrink tumors most effectively with ac…

This study is testing a new three-part treatment for advanced colon cancer that has spread to the liver and isn't responding to standard drugs. It combines an immunotherapy drug, a targeted cancer drug, and a short course of radiation, and compares it to the usual third-choice th…

This study is testing whether a new combination of two drugs can help control advanced colorectal cancer that has stopped responding to standard treatments. It will involve about 18 patients whose cancer has specific immune markers. The goal is to see if this combination can shri…

This study is comparing two different drug combinations for people with advanced colorectal cancer that has spread and stopped responding to standard chemotherapy. Researchers want to see if adding fruquintinib to chemotherapy works better or is safer than adding bevacizumab to t…

This trial is testing a new robotic surgery system that allows surgeons to perform operations remotely. It will be used on patients needing surgery for cancers like colorectal or esophageal cancer, as well as other procedures in urology, gynecology, and general surgery. The main …

This study is testing whether the drug everolimus can help control advanced colorectal cancer that has a specific genetic change called CDK12 deficiency and has stopped responding to standard treatments. The trial will first find the safest dose, then see if the drug shrinks tumo…

This large international trial aims to personalize chemotherapy for patients with stage III colon cancer. After surgery, a blood test looks for tiny traces of leftover cancer. Patients with a negative test may get a shorter, gentler chemo regimen, while those with a positive test…

This study aims to see if applying a gentle heat treatment to the area after removing a large, flat colon polyp can help prevent it from growing back. It will involve 752 adults who are having these polyps removed during a standard colonoscopy. Researchers will compare the regrow…

This study is testing whether a special nutritional drink with omega-3 fatty acids (like those in fish oil) can help people with advanced lung or colorectal cancer who are at risk of malnutrition. About 118 participants will be split into two groups: one gets the omega-3 drink pl…

This study is testing a new program called ONLOOP that reminds adult survivors of childhood cancer in Ontario to get important health screenings. Many survivors are at higher risk for heart problems, breast cancer, or colon cancer due to their past cancer treatments, but often mi…

This study is testing a new three-drug combination given before surgery for locally advanced colorectal cancer. The goal is to see if adding an immunotherapy drug and a diabetes drug (sitagliptin) to standard chemotherapy can shrink tumors more effectively. The trial will first c…

This is the first study in humans testing a new cancer drug called QLS5316. Researchers will give the drug to 300 patients with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check if the drug is safe, determine the right dose, an…

This early-stage study is testing a new cell-based treatment called SL-28 in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find the safest and most effective dose and to check for side effects. Participants will receive the…

This study is testing whether adding a new immunotherapy drug (aipalolitovorelizumab) to standard chemotherapy and another targeted drug (bevacizumab) works better for people with advanced colorectal cancer that has spread and has a specific genetic change called BRAF V600E. The …

This early-stage study is testing a new vaccine called YMN-136 in people with advanced colorectal cancer that has spread to the liver and has stopped responding to at least three previous treatments. The main goals are to check if the vaccine is safe and to find the right dose fo…

This trial aims to see if a specific biomarker test can help doctors choose the best first treatment for patients with advanced colon cancer that started on the right side. It will test if patients with a 'high' biomarker result do better when a targeted drug (cetuximab) is added…

This early study is testing a new cell therapy called NK510 for people with advanced stomach or colorectal cancer that has come back or stopped responding to standard treatments. The study will give NK510 through an IV or directly into the abdomen to see if it is safe and if it h…

This study is testing if a dietary supplement called SAMe can prevent liver damage caused by a common chemotherapy drug (oxaliplatin) in patients with colorectal cancer that has spread to the liver. About 30 patients will take SAMe pills daily during their 3-6 months of chemother…

This early-phase trial is testing a new type of treatment for people with colorectal cancer that has spread to the lining of the abdomen. Doctors are giving patients specially modified immune cells, called CAR-NK cells, directly into the abdomen and bloodstream, along with a stan…

This study is testing a new imaging device called ActivSight that helps surgeons see blood flow in real-time during colon cancer surgery. The goal is to see if this tool is as good as or better than the current standard dye method at showing which tissue is healthy, which could h…

This study is testing whether a new blood marker can help doctors better identify who needs a colonoscopy for colon cancer screening. Researchers will analyze blood samples from 2,000 people scheduled for colonoscopies to see if this marker, combined with existing stool tests, ca…

This study is testing whether an artificial intelligence (AI) system can help doctors find more polyps and early cancers during a routine colonoscopy. About 3,300 people will be randomly assigned to have their colonoscopy done with or without the AI assistant. The goal is to see …

This study is testing a new type of PET scan designed to improve the detection and staging of colorectal, gastric, and pancreatic cancers. It uses a special imaging agent that targets a protein called GPA33, which is often found on these cancer cells. The goal is to see if this n…

This study is testing a new type of PET/CT scan to see if it can better detect cancer that has spread to the lining of the abdomen (peritoneal carcinomatosis) in patients with certain cancers. About 175 adults with colorectal, gastric, ovarian, or pancreatic cancer who are suspec…

This study aims to see if giving patients several stool tests (FIT tests) over a few weeks, instead of just one or two, helps doctors better identify who really needs a colonoscopy to check for bowel cancer. It will involve about 1,000 people in Scotland who have been referred to…

This study is testing a new monitoring device called xBar that's placed during colon cancer surgery. The device continuously checks how the surgical connection is healing to detect potential leaks early. Researchers will compare recovery outcomes for 80 patients using this sensor…

This study aims to see how accurately a simple stool test can detect colon cancer and precancerous growths. Researchers will compare the test results from 150 adults with findings from their routine colonoscopies. The goal is to understand if this non-invasive test can reliably i…

This study aims to see if offering a blood test option alongside standard reminders helps more people complete colon cancer screening. Researchers will compare two groups: one gets standard mail/email reminders, while the other gets those same reminders plus the option to do a bl…

This study is testing if getting colorectal cancer screening kits through community pharmacies helps more people complete this important preventive test. About 1,500 adults who are behind on their recommended screenings will be randomly assigned to either receive the pharmacy-bas…

This study is testing whether a text message support program can help homeless adults get screened for colorectal cancer. It will involve about 588 people aged 45-75 who are staying in New York City shelters and are overdue for screening. Researchers will compare screening rates …

This study tests whether having family doctors proactively give colon cancer screening kits to eligible patients improves participation rates. It compares this direct approach to the current system where people receive invitation letters in the mail. The goal is to find better wa…

This study is testing a new 'Flipped Discharge' support program for colorectal cancer patients who have a new stoma after surgery. The program shifts key care and education from the hospital to the home, providing a nurse visit or intensive video follow-up a few days after patien…

This study is testing whether a probiotic supplement called Clostridium butyricum can help reduce severe side effects, especially diarrhea, in people receiving chemotherapy after colon cancer surgery. About 240 patients who have had surgery will be randomly assigned to take eithe…

This study tests whether pairing newly diagnosed Latinx colorectal cancer patients with a community health worker navigator improves their quality of life. Sixty participants in Santa Clara County will be randomly assigned to receive either this personalized support or a standard…

This study aims to see if a specially adapted version of Baduanjin, a gentle Chinese exercise, is safe and helpful for people living with a stoma after colorectal cancer surgery. Researchers will compare it to regular walking to see which better improves sleep, reduces fatigue, a…

This study is testing whether a specialized form of talk therapy, called Meaning-Centered Psychotherapy for Latinos (MCP-L), can better reduce anxiety and depression and improve quality of life for Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. It…

This study is testing a web-based tool called CARE that helps cancer patients understand treatment costs, health insurance, and find financial resources. Researchers will enroll 430 patients with gynecologic, prostate, lung, or colorectal cancer to see if using the tool reduces f…

This study tests if a guided exercise program, tracked by a smartwatch, can help reduce the severe fatigue many people experience after finishing chemotherapy for cancer. It will involve 98 adults who have recently completed treatment for certain cancers. Researchers will compare…

This study is testing whether a home-based exercise program can help reduce memory problems and brain fog (often called 'chemo brain') in older adults receiving chemotherapy for colorectal cancer. Participants aged 60-85 will follow a supervised video exercise program before and …

This study is testing whether watching a virtual reality training video helps patients feel more confident and capable in managing their own recovery after colorectal cancer surgery. Researchers will compare two groups of 66 patients: one group watches the VR training after surge…

This small pilot study aims to see if a larger trial is feasible to test a daily irrigation procedure for people suffering from severe bowel problems after rectal cancer surgery. The procedure, called transanal irrigation, involves using water to help empty the bowel on a schedul…

This study is testing different blood test methods to detect tiny amounts of leftover cancer cells in people who have had surgery for stage III colorectal cancer. Researchers will collect blood samples from 229 patients and analyze them to see which test method best predicts if c…

This study aims to test whether growing tiny tumor models from a patient's own cancer cells in a lab can help predict which standard cancer drugs will work best for them. Researchers will enroll 188 adults with colorectal or pancreatic cancer who are scheduled for surgery or biop…

This study aims to see if the microscopic growth pattern of a tumor can help doctors better predict which patients will benefit from major abdominal surgery. It will enroll 30 patients with colorectal cancer that has spread to the abdominal lining. Researchers will analyze tumor …

This study aims to understand why some colorectal cancer patients experience severe fatigue. Researchers will examine 80 patients' body chemistry and traditional Chinese medicine body types to find patterns. The goal is to identify biological markers that might explain fatigue di…

This early study is testing a new radioactive imaging agent called LNTH-2403 in people with advanced cancers that have spread or can't be removed. The main goals are to see if it's safe and to track where it goes in the body using special scans. Researchers want to learn if this …