COLORECTAL CANCER

This early-stage study tests a new vaccine called YMN-136 in 9 people with advanced colorectal cancer that has spread to the liver and no longer responds to standard treatments. The main goals are to check the vaccine's safety and find the best dose. Researchers will also watch f…

This early-stage study tests a new drug called SNA028 in 20 people with advanced colorectal cancer that has gotten worse after standard treatments. The drug uses a two-step process to deliver radiation directly to cancer cells that have a specific marker (GPA33). The main goals a…

This study tests a new drug, telisotuzumab adizutecan, combined with bevacizumab, against the standard treatment (LONSURF plus bevacizumab) in about 700 adults with advanced colorectal cancer that has stopped responding to prior therapies. The goal is to see if the new combinatio…

This study tests the drug everolimus in people with advanced colorectal cancer that has a specific genetic change (CDK12 deficiency) and has not responded to other treatments. The goal is to see if the drug can shrink tumors or slow the cancer's growth, and to find the safest dos…

This early-phase study tests a new drug called RP-001 in 66 adults with advanced solid tumors, including colorectal and pancreatic cancers. The main goal is to check safety and find the best dose. Researchers will also watch for any signs that the drug shrinks tumors.

This study tests whether adding immunotherapy drugs (cemiplimab alone or with fianlimab or REGN7075) to standard chemotherapy can improve outcomes for people with locally advanced rectal cancer before they have surgery. About 66 adults with a specific type of rectal cancer (MSS) …

This phase 3 trial tests whether a new drug, fruquintinib, combined with chemotherapy works better than the standard treatment (bevacizumab plus chemo) for people with a specific type of advanced colorectal cancer (RAS-mutant). About 224 adults aged 18-75 with metastatic disease …

This early-stage trial tests a new drug called TB511, alone or with pembrolizumab, in 12 adults with advanced solid tumors (lung, prostate, colorectal, or liver cancer) that stopped responding to standard treatments. The goal is to find the safest dose and see if it can shrink tu…

This study tests a new drug called AMT-676 combined with standard chemotherapy drugs in 180 people with advanced colorectal cancer that cannot be removed by surgery. The goal is to see if the combination is safe and helps control the cancer. Participants will receive the treatmen…

This study tests whether burning the edges of the spot where a large colon polyp was removed can stop new polyps from growing there. About 752 adults with large, flat polyps will either get standard removal alone or removal plus heat treatment. Researchers will check for polyp re…

This study tests a treatment for people whose colorectal cancer spread to the liver and was surgically removed. After surgery, participants get a liver-directed chemo drip plus standard chemo pills and IV drugs for 2 to 4 cycles. The goal is to see if this combination helps keep …

This early-phase study tests a combination of a specially designed virus (PIN) and an immunotherapy drug (sintilimab) in up to 25 adults with advanced colorectal cancer that has spread to the liver and hasn't responded to at least two prior treatments. The goal is to see if this …

This study tests a new drug combination (fruquintinib plus trifluridine/tipiracil) against a standard combo (bevacizumab plus trifluridine/tipiracil) in people with advanced colorectal cancer that has not responded to standard chemotherapy. About 292 adults aged 18-75 will take p…

This study tests a new combination of drugs (aipalolitovorelizumab, bevacizumab, and chemotherapy) as a first treatment for people with advanced colorectal cancer that has a specific gene change called BRAF V600E. The goal is to see if this combo shrinks tumors and controls the d…

This early-stage study tests a new drug called QLS5316 in about 300 people with advanced solid tumors (such as colorectal, stomach, head and neck, or lung cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, a…

This study tests a new robotic system that lets surgeons operate from a distance during laparoscopic cancer surgeries. It includes 98 adults with colorectal, esophageal, liver, or cervical cancer who need certain procedures. The main goal is to see if the robot can complete the s…

This early-stage study tests a new drug called CT-202 in people with advanced triple negative breast, colorectal, or urothelial cancers that have come back or spread. The drug is designed to help the immune system attack cancer cells. The main goals are to check safety and find t…

This early-phase study tests a new cell therapy called NK510 in 15 people with advanced stomach or colon cancer that has not responded to standard treatments. The therapy is given through an IV or directly into the belly to see if it is safe and can shrink tumors. The goal is to …

This early-stage study tests a new drug called IM-1617 in about 175 people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, finding the right dose, th…

This study tests whether adding two drugs (pirfenidone and sintilimab) to standard chemotherapy can shrink tumors in people with colorectal cancer that has spread to the lining of the abdomen. About 30 adults aged 18 to 75 will receive the treatment for 4 cycles, then doctors wil…

This study tests whether a new combination of an antibody drug (QL1706), a targeted therapy (fruquintinib), and short-course radiotherapy can help control advanced colorectal cancer that has spread to the liver and hasn't responded to earlier treatments. About 76 adults aged 18 t…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study looks at whether a biomarker test (EREG/AREG) can help decide if adding a targeted drug (cetuximab) to standard chemotherapy works better for people with advanced right-sided colorectal cancer. About 280 adults with wild-type RAS tumors will be enrolled. The goal is to…

This study tests a program called ONLOOP that sends reminders to adult survivors of childhood cancer in Ontario to get important screening tests. These tests can find late effects like heart disease or second cancers early. About 900 survivors will be randomly assigned to receive…

This study tests whether a special omega-3-enriched nutritional drink can help people with lung or colorectal cancer who are losing weight and at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The goal is …

This study tests a combination of chemotherapy, an immunotherapy drug, and a diabetes drug (sitagliptin) in people with a specific type of advanced colorectal cancer. The goal is to shrink tumors before surgery. About 138 adults aged 18-75 with locally advanced, non-metastatic co…

This study tests whether giving chemotherapy directly into the liver artery (HAI) after surgery can delay cancer return in 272 people with colorectal cancer that spread to the liver and is at high risk of coming back. Participants will get standard IV chemo plus either HAI or IV …

This early study tests a new drug called SHR-3821 combined with fruquintinib in people with advanced colorectal cancer that has not responded to at least two prior treatments. The main goals are to check safety and see if the combination can shrink tumors. Only 12 participants wi…

This early-phase study tests a combination of two drugs—aipalirovorelizumab (QL1706) and fruquintinib—in 18 adults with a specific type of advanced colorectal cancer (pMMR/MSS) that has not responded to at least two prior treatments. The goal is to see if the combination can shri…

This study looks at whether a non-invasive stool test (qFIT) can accurately detect colorectal cancer and precancerous lesions in adults aged 40–75 who are already scheduled for a colonoscopy. Researchers will compare the test results with colonoscopy findings to see how well qFIT…

This study tests whether an artificial intelligence system can help doctors spot more precancerous polyps and early colorectal cancers during colonoscopy. Over 3,300 adults will be randomly assigned to either AI-assisted or standard colonoscopy. The goal is to see if AI can reduc…

This study aims to improve how bowel cancer is detected in people referred to hospital with symptoms. Around 1,000 patients will provide extra stool samples to see if changes in blood levels over time can better identify who needs a colonoscopy. The goal is to catch cancers earli…

This study aims to improve how we screen for colorectal cancer by using a new blood test. Researchers will look for special molecules called oncofetal chondroitin sulfate (ofCS) that appear in tumors. They will collect blood from 2000 people scheduled for a colonoscopy to see if …

This early study tests a new radioactive antibody (NTH-2403) that attaches to a protein found on certain cancer cells and their supporting cells. The goal is to see if it can safely light up tumors on scans in people with advanced colorectal, head and neck, lung, or triple-negati…

This study tests a new type of PET scan that uses a special probe to find cancers that have a protein called GPA33. The study will include 56 people with suspected or confirmed colorectal, stomach, or pancreatic cancer, as well as healthy volunteers. The goal is to see if this im…

This study looks at whether offering a simple blood test (called Shield) can encourage more people who are overdue for colon cancer screening to get checked. About 500 adults aged 45-85 will be randomly assigned to either receive a standard reminder or also have the option to giv…

This study tests whether taking S-adenosylmethionine (SAMe), a common supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin in people with colorectal cancer that has spread to the liver. About 30 participants will take SAMe pills daily for 3-6 months al…

This study tests whether text message reminders can increase colorectal cancer screening among homeless adults aged 45-75 who are not up to date on screening. Participants will be randomly assigned to receive SMS texts or standard care. The goal is to see if texting helps more pe…

This study tests whether having general practitioners proactively hand out colorectal cancer screening kits to eligible patients (ages 50-74) increases screening participation compared to the usual method of sending invitation letters. About 26,260 people in France will take part…

This study tests whether a prehabilitation (prehab) exercise program can reduce 'chemo brain'—memory loss, forgetfulness, and brain fog—in older adults (60-85) with colorectal cancer before they start chemotherapy. Participants will be assigned to either the exercise program or u…

This study tests a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) to see if it helps reduce anxiety and depression and improve quality of life in 300 Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. Participants will be randomly a…

This study tests whether a virtual reality video training session can improve self-confidence (self-efficacy) in patients recovering from colorectal cancer surgery. About 66 adults will be split into two groups: one gets the video training on day two after surgery, the other gets…

This study tests whether community health workers (called promotoras) can improve quality of life for 60 newly diagnosed Latinx colorectal cancer patients in Santa Clara County. Participants will either get support from a health worker or just a list of social services. The goal …

This study tests if a smartwatch-guided exercise program helps cancer survivors feel less tired after finishing chemotherapy. About 98 adults with certain cancers (breast, colorectal, ovarian, pancreatic, stomach) will either follow the exercise program or receive standard care. …

This study tests whether a simple bowel irrigation technique can help people who have bowel control problems after rectal cancer surgery. About 60 adults who recently had surgery and a temporary colostomy will try the irrigation method or standard care. The goal is to see if it i…

This study tests whether a probiotic called Clostridium butyricum can lessen severe diarrhea and other side effects during chemotherapy for colorectal cancer. About 238 adults who had surgery for colorectal cancer and need follow-up chemo will take either the probiotic or a place…

This study tests whether a supervised exercise program, started before chemotherapy and continued during treatment, helps adults aged 35 to 65 with breast, lung, or colon cancer tolerate chemo better. The goal is to see if participants can receive more than 85% of the planned che…

This study aims to see if a specially adapted version of Baduanjin, a traditional Chinese exercise, is safe and helpful for people living with a stoma after colorectal cancer surgery. Researchers will compare the gentle Baduanjin movements to regular walking over 12 weeks. They w…

This study aims to understand why some people with colorectal cancer feel very tired. Researchers will look at how the body's metabolism and Traditional Chinese Medicine body types relate to fatigue. The study involves 80 adults with early-stage colorectal cancer who will fill ou…

This study looks at whether tumor DNA found in blood or belly fluid can predict if stomach, colon, or pancreatic cancer will spread to the lining of the abdomen (peritoneum). Researchers will follow 300 people with early-stage cancers to see if those with positive DNA tests have …

This study will examine tissue samples from 30 adults with colorectal cancer that has spread to the lining of the abdomen (peritoneal metastases). Researchers want to see if the way the tumor grows into the peritoneum can help predict which patients will do well with surgery and …

This study aims to see if a new, simpler scoring tool (CRIS) can help doctors accurately predict which large colon polyps contain cancer. About 764 patients and many endoscopists will take part in image reviews and live procedures. The goal is to improve treatment choices and red…

This study looks at whether a special decision aid helps patients with a cancerous colon polyp choose between more surgery or just monitoring. About 110 adults who had a polyp removed but may still have cancer cells will use the aid during their doctor visit. The goal is to see i…

This study aims to see if text message reminders can encourage more adults aged 45-75 to complete at-home colorectal cancer screening. Researchers will work with community health centers to design and test different message versions. About 7,220 participants will receive texts, a…

This study looks at whether a new blood test can find tiny bits of cancer DNA left after surgery in people with stage III colorectal cancer. About 229 patients will give blood samples, which will be checked using two methods to see which better predicts if the cancer will come ba…

This study tests a new imaging tool that helps surgeons see blood flow in real time during colon cancer surgery. About 150 adults will have both standard dye imaging and a new laser speckle imaging method to check tissue health. The goal is to see if the new method helps surgeons…

This observational study looks at how histidine, an amino acid, and its transporter SLC15A3 affect how well colorectal cancer responds to immunotherapy. Researchers will measure histidine levels in blood and SLC15A3 in tumor tissue from 150 patients. The goal is to find new ways …

This study tests whether a simple blood test that looks for tumor DNA (ctDNA) can help doctors choose the right amount of chemotherapy for people with stage III colorectal cancer. About 2,450 participants will be split into groups based on their ctDNA results: those with no detec…

This study tests a 'Flipped Discharge' program for 200 colorectal cancer patients who have a new stoma after surgery. Instead of standard hospital discharge, patients get a home visit or video follow-up from a specialist nurse on day three after leaving the hospital. The goal is …

This study involves 70 patients with various cancers who are receiving biotherapy drugs. Researchers want to find the highest safe concentration of these drugs to use in skin allergy tests, so they can better diagnose allergic reactions. The goal is to create clear guidelines for…

This study is testing a new method called Personalized Functional Profiling (PFP) to see if it can predict which standard cancer drugs will work best for people with colorectal or pancreatic cancer. Researchers will take tumor samples from 188 patients, grow them in the lab, and …

This study looks at whether offering colorectal cancer screening kits through community pharmacies makes it easier for people to get screened. About 1,500 patients and pharmacy staff will take part. The goal is to see if this approach increases screening rates and is practical fo…

This study aims to check the safety of a cancer drug called bevacizumab (and its biosimilar version) when used by real patients with colorectal cancer in Japan. Researchers will look at the medical records of about 1,000 patients treated between 2019 and 2024 to see how often cer…