COLORECTAL CANCER

This study tested whether adding a targeted antibody drug (cetuximab) to a standard chemotherapy combination works better as the first treatment for colorectal cancer that has spread. It involved 42 patients with metastatic colorectal cancer who hadn't received prior treatment fo…

This study tested whether adding a specialized geriatric care team to standard cancer treatment could help older patients. It involved 792 patients aged 70 and older with various advanced cancers. The goal was to see if this coordinated care approach improved survival and quality…

This early-stage study tested the safety of a heated chemotherapy solution, called Raltitrexed, when washed directly into the abdomen during surgery for colorectal cancer. The goal was to find the highest dose patients could tolerate without severe side effects. This information …

This study tested whether using more intensive chemotherapy combinations could help people with colorectal cancer that had spread to the liver and could not be easily removed by surgery. It compared a standard two-drug treatment against three different, stronger chemotherapy opti…

This was a first-in-human study to find a safe dose of a new experimental cancer drug called SNB-101. The drug, a nanoparticle form of an existing chemotherapy, was given by IV to 21 patients with advanced solid tumors that had stopped responding to standard treatments. The main …

This early-stage study tested whether adding a new investigational therapy called VE800—a preparation of specific bacteria—could improve the effectiveness of an existing immunotherapy drug (nivolumab) in patients with advanced or metastatic cancers. The trial enrolled 56 patients…

This study tested whether a specific pump and catheter system was a safe way to deliver chemotherapy directly into the liver for patients with colorectal cancer or cholangiocarcinoma that had spread to the liver. The goal was to see if this method could control the cancer in the …

This study tested a new drug called gevokizumab when added to standard cancer treatments. It involved 167 adults with advanced colorectal, gastroesophageal, or kidney cancer that had spread. The main goals were to find a safe and effective dose and to see if the combination could…

This first-in-human study tested a new oral drug called JAB-3312 in 40 adults with advanced solid tumors that had progressed despite standard treatments. The main goals were to find the safest dose and see how the body processes the drug. Researchers also looked for early signs t…

This study tested a combination of three targeted drugs (encorafenib, binimetinib, and cetuximab) given for 8 weeks before surgery to people with a specific genetic type of localized colon cancer (BRAF V600E mutated). The goal was to see if this 'neoadjuvant' approach could shrin…

This study tested whether a combination of daily aspirin, vitamin D, a low-fat diet, and regular exercise could help prevent colorectal cancer from coming back. It involved 16 patients who had completed their main cancer treatment but still had tiny traces of cancer DNA in their …

This early-stage trial tested a new immunotherapy called ELI-002 in 25 people with pancreatic, colorectal, lung, and other cancers that have specific KRAS mutations. The treatment was given after standard therapy to target any remaining cancer cells and prevent recurrence. Resear…

This early-stage study tested a new immunotherapy drug called CUE-102 in patients with advanced cancers that had returned or spread after standard treatments. The main goals were to find a safe dose and see how the body processes the drug. It involved 42 adults with specific type…

This study tested whether adding a new immunotherapy drug (SAR444245) to other standard cancer drugs could help control advanced cancers of the digestive system, including stomach, liver, and colon cancers. It involved 138 adults whose cancer had spread and was no longer respondi…

This study tested if specially trained nurse practitioners could monitor patients with colorectal cancer during their intravenous chemotherapy as safely and effectively as doctors. It involved 207 patients in France. The goal was to see if this new care model could free up doctor…

This study tested the safety and best dose of a combination of two drugs, regorafenib and nivolumab, for people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to see how much of the drug combination patients could tolerate an…

This study asked patients with advanced colorectal cancer which of two chemotherapy treatments they preferred after trying both. The trial involved 89 participants and aimed to understand patient choice while also comparing the safety of each treatment option. Researchers wanted …

This study tested a new method for adjusting chemotherapy doses to prevent unplanned treatment delays. It involved 52 adults with cancers of the digestive system (like colorectal or stomach cancer) who were receiving a common chemotherapy regimen called FOLFOX. The goal was to se…

This completed Phase 3 trial tested whether a new two-in-one immunotherapy drug (MK-4280A) works better than standard chemotherapy for Chinese adults with advanced colorectal cancer that had spread and stopped responding to prior treatments. The main goal was to see if the new tr…

This study tested a new drug called BMS-813160, given alone or combined with standard chemotherapy and/or an immunotherapy drug (nivolumab), in people with advanced colorectal or pancreatic cancer that had spread. The main goals were to find the safest dose, see how the body proc…

This study tested whether adding two drugs that can modify how genes work (epigenetic modulators) could help a type of immunotherapy (MK-3475) work better for people with a hard-to-treat form of advanced colorectal cancer. It involved 27 adults whose cancer had progressed despite…

This study aimed to find the best length of immunotherapy treatment for people with advanced cancers. It enrolled 161 patients whose cancer had remained stable after one year of treatment. Researchers randomly assigned participants to either stop their immunotherapy or continue i…

This study tested whether combining the immunotherapy drug nivolumab with the targeted therapy trametinib, with or without another immunotherapy called ipilimumab, could help control advanced colorectal cancer that had spread and stopped responding to prior treatments. It involve…

This study tested whether using a simple wristband to track early walking after colorectal cancer surgery could help patients recover better. Researchers monitored 192 patients' activity, heart rate, and sleep for about a week after their operation. The goal was to see if encoura…

This study tested whether a new two-drug combination called MK-4280A works better than standard treatments for people with advanced colorectal cancer that has spread and stopped responding to prior therapies. It involved 441 participants whose cancer tested positive for a specifi…

This study tested whether giving the immunotherapy drug tislelizumab before surgery could help people with early-stage colorectal cancer that has specific genetic features (called MSI-H or dMMR). The goal was to see if the drug could shrink or even eliminate the tumor before it w…

This study tested a specialized pump implanted in the body to deliver chemotherapy drugs directly into the liver's main artery. The goal was to see if this targeted approach could better control colorectal cancer that had spread to the liver. It involved 24 adult patients who had…

This study looked at 698 patients with advanced colorectal cancer to understand how ongoing inflammation in the body affects a common treatment drug (Bevacizumab) combined with chemotherapy. Researchers measured patients' inflammation levels and tracked how long they lived and ho…

This study tested a new web and text message program designed to help people who have had colorectal cancer eat healthier. Researchers wanted to see if the program was easy to use and acceptable to 50 cancer survivors over 12 weeks. The goal is to help survivors make dietary choi…

This early-stage study tested the safety of a new drug called GDC-1971 when given alongside standard cancer medications. It involved 10 patients with advanced lung or colorectal cancer whose disease had progressed despite previous treatments. The main goal was to find a safe dose…

This early-stage study tested a new drug called SHR-A1811 in 101 patients with advanced stomach or colorectal cancer that had stopped responding to standard treatments. The main goals were to find a safe dose and check for early signs that the drug might help control these cancer…

This study tested if combining the oral drug TAS-102 with targeted radiation therapy (SBRT) is safe and effective for controlling colorectal cancer that has spread to the liver. The goal was to find the best dose and see if the drug makes the radiation work better to kill cancer …

This early-phase study tested a new oral drug called revumenib (SNDX-5613) in 42 adults with advanced colorectal cancer or other solid tumors that had worsened despite at least one prior treatment. The main goals were to find a safe dose, see how the body processes the drug, and …

This study tested if adding a drug called pembrolizumab to standard pre-surgery treatments could help the body's immune system fight colorectal cancer. It involved 33 patients with non-metastatic colon or rectal cancer who received the immunotherapy along with their usual chemoth…

This early-stage study aimed to find a safe and effective dose of a new drug called TPST-1495, given alone or with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors. It enrolled 89 adults with cancers like colorectal, lung, and head and neck cancer …

This early-stage study tested a new cancer vaccine designed to teach the body's immune system to recognize and attack tumors. It involved 43 people with advanced colorectal, lung, breast, or prostate cancer that had stopped responding to standard treatments. The main goals were t…

This study tested the safety and effectiveness of combining two drugs, pembrolizumab and lenvatinib, in people with advanced solid tumors that had stopped responding to standard treatments. It involved 611 participants with cancers like triple-negative breast, ovarian, gastric, c…

This study tested a safer way to give IV nutrition to patients recovering from colon surgery. Researchers wanted to see if giving nutrition through a regular arm IV (instead of a deep chest line) could help patients heal better and avoid complications. They enrolled 200 patients …

This study aimed to find the best way to screen healthy people for colon cancer. It directly compared two common methods: a one-time colonoscopy versus taking an annual stool test (FOBT). Nearly 5,000 participants aged 50-69 were randomly assigned to one of these screening approa…

This study tested if using a small, swallowable camera capsule could improve colon cancer screening. Over 2,000 people in Denmark's national screening program were involved. The goal was to see if this easier, less invasive method could get more people screened and reduce the nee…

This study investigated whether analyzing the bacteria in a person's stool could help predict their risk for colon cancer or pre-cancerous growths called adenomas. Researchers collected samples from over 1,700 people with different colon health statuses to see if specific bacteri…

This study looked at whether offering a simple blood test could get more people screened for colon cancer. It focused on 297 people aged 45-75 who had previously skipped or refused recommended stool tests or colonoscopies. Researchers offered a free blood test during regular clin…

This small, completed study tested whether ultrasound could be a better way to detect nerve damage caused by the chemotherapy drug oxaliplatin. Researchers compared ultrasound images of leg nerves from 20 patients with gastrointestinal cancer to data from healthy people. The goal…

This study tested a new type of PET scan designed to better detect and locate gastrointestinal cancers. The scan uses a special tracer that attaches to a protein often found in these tumors. Researchers compared the scan results to tissue samples from 109 patients to see how accu…

This study tested whether using two tools together helps doctors find more pre-cancerous growths (adenomas) during a colonoscopy. The tools are an artificial intelligence (AI) system that highlights suspicious areas and a small cap that helps flatten the colon wall for a better v…

This study tested whether measuring certain proteins in the blood could help screen for colorectal cancer. It involved 350 adults aged 50 or older who were already scheduled for a colonoscopy. The goal was to see if a future blood test could be an easier screening option.

This study tested whether a simple blood test using artificial intelligence could detect colorectal cancer early. Researchers collected blood samples from nearly 49,000 average-risk adults aged 45-85 who were already scheduled for routine colonoscopy screening. The goal was to se…

This study tested a community-wide program designed to get more people in Appalachian Kentucky and Ohio screened for colorectal cancer. It worked with clinics, healthcare providers, and local residents to encourage screening for adults aged 50-74. The goal was to see if this coor…

This study looked at whether applying a topical anti-inflammatory gel (diclofenac) to the hands and feet could prevent or delay a painful skin reaction called Hand-Foot Syndrome in patients receiving capecitabine chemotherapy for colorectal or gastric cancer. About 150 patients w…

This study tested a multi-part program designed to increase colorectal cancer screening and follow-up care in community health centers. The program targeted doctors, clinic staff, and patients with education, reminders, and navigation help. The goal was to find out if this combin…

This study tested whether a new, at-home stool DNA test could help more Alaska Native people get screened for colon cancer. Over 2,000 adults were offered different levels of support to use the test, from mailed kits with reminders to full patient navigation. The goal was to see …

This study aimed to find the best way to get more people screened for colorectal cancer in community health centers. Researchers mailed two different at-home screening tests (FIT and Cologuard) to over 5,000 patients who were overdue for their check. They compared which test peop…

This study tested whether text messages and educational videos could help childhood cancer survivors get screened for colorectal cancer. Researchers enrolled 300 survivors at high risk and randomly assigned them to receive different levels of support. The goal was to find the mos…

This study tested whether taking magnesium supplements could help prevent colorectal cancer in people at higher risk. Researchers enrolled 250 people who had a specific genetic marker and diets high in calcium relative to magnesium. The goal was to see if adjusting this dietary b…

This study tested whether a special smartphone program could help more African American men get screened for colorectal cancer. Researchers compared the new program, which sent text messages and videos, to standard educational texts. They checked six months later to see which gro…

This study tested a new program to help more people in underserved Philadelphia neighborhoods get screened for colon cancer. Researchers used a computer program (AI) to identify 385 high-risk patients who had a screening test ordered but not completed. They then provided these pa…

This study tested whether training family doctors to better discuss two different screening tests—colonoscopy and a simple at-home stool test—would lead more patients to get screened for colorectal cancer. It involved 44 Swiss doctors and their patients aged 50-75. The goal was t…

This study tested whether training rural primary care doctors remotely could get more people to complete colonoscopy screening for colorectal cancer. Over 20,000 residents aged 45-70 in Chinese villages participated. Villages were randomly assigned to either receive the doctor tr…

This study tested an 11-step community program designed to help more African Americans get screened for colon cancer. It worked with 163 people aged 45-75 who were overdue for screening, providing education, risk assessment, and practical help to overcome common barriers like cos…

This study tested different ways to get more people screened for colorectal (colon) cancer at a community health center serving mostly Latino patients. Researchers compared sending test kits in the mail, having health workers help patients in the clinic, doing both, or just givin…

This study tested whether a drug called Neurotropin can prevent or reduce nerve damage (neuropathy) caused by a common chemotherapy drug, oxaliplatin, in people with stage II or III colorectal cancer. Over 300 patients were randomly assigned to receive either Neurotropin or a pla…

This study tested if a special pre-surgery education class could help people recover better after colon cancer surgery. 88 patients were randomly assigned to either get the new class or the usual pre-surgery instructions. The class explained what to expect before and after surger…

This study tested a new support program for older adults who have finished treatment for breast, colorectal, or prostate cancer. A community health worker met with 30 participants to assess their overall health and provide personalized coaching. The goal was to see if this approa…

This study tested whether Reiki, a gentle touch therapy, could help patients feel better after surgery for colorectal cancer. Researchers worked with 64 patients to see if Reiki could reduce their pain and anxiety, improve their vital signs, and help them recover faster. The goal…

This study tested a new smartphone app called PainPac, designed to help people with colorectal cancer manage their pain. Researchers compared the app to traditional video therapy sessions to see if it was easy to use and helpful. The goal was to see if a mobile app could be a con…

This study tested whether a personalized nursing approach improves recovery for people having surgery for colorectal cancer. 90 patients were randomly assigned to receive either this tailored care or standard nursing. The personalized care included special counseling before surge…

This small, early-stage study tested a new 6-session group program designed to help female colorectal and anal cancer survivors improve their sexual well-being after treatment. The main goal was to see if the program was practical and acceptable to participants, and to gather the…

This study tested whether a common antioxidant supplement, N-Acetylcysteine (NAC), could protect against nerve damage caused by a chemotherapy drug for colorectal cancer. Forty-six patients receiving oxaliplatin chemotherapy were randomly assigned to also receive NAC or not. The …

This study tested a new supportive corset designed to make portable chemotherapy pumps more comfortable for patients. Forty people with colorectal cancer were split into two groups: one used the new corset, and the other received standard care. Researchers measured if the corset …

This study tested a mobile app called 'STOMA Care' to see if it was helpful and easy to use for people with bladder or colorectal cancer who were getting an ostomy and their caregivers. The app provided information, videos, and support to help with stoma care skills, reduce distr…

This small pilot study tested whether connecting people with advanced colorectal cancer to free legal services could help reduce their stress, financial strain, and improve their quality of life. Twenty participants received personalized legal care for six months while continuing…

This study looked back at medical records to understand what factors help patients successfully have repeat surgery when their initial rectal cancer surgery fails or the cancer returns locally. Researchers analyzed 143 patients who underwent this redo surgery to see who was able …

This study tested an online education program to teach people in rural New Hampshire and Vermont about colon cancer screening. Researchers wanted to see if the program increased people's knowledge about screening and their intent to get screened. They surveyed 205 participants be…

This study tested whether a specially designed pamphlet could help older adults with low health literacy make better decisions about colorectal cancer screening. Researchers worked with 60 adults aged 75-85 to see if the pamphlet improved their understanding of screening options …

This study aimed to understand what types of bacteria live in the mouth and gut of people with serrated polyposis syndrome, a condition that increases colon cancer risk. Researchers compared these patients to people with other types of colon polyps and to people with no polyps. T…

This study looked at why some cancer patients who get a second opinion decide to stay with their original doctor, while others switch to the new doctor. Researchers reviewed the records of 236 patients with breast, pancreatic, or colorectal cancer who got a second opinion at the …

This study aimed to find a better way to predict how aggressive colorectal cancer might be. Researchers measured levels of a protein called tissue factor in the blood of 26 adults before and after cancer surgery. They wanted to see if this protein level could indicate the cancer'…

This study tested whether sending text message reminders could get more people to participate in routine cancer screening programs. Researchers compared text messages to standard mail reminders for over 44,000 people eligible for breast or colorectal cancer screening. They measur…

This study tested two new methods to encourage people at higher risk for hereditary cancers to get recommended genetic testing. Over 800 participants in Michigan were randomly assigned to either use a special website, receive two coaching phone calls, or get standard information.…

This study aimed to discover if a simple blood test could detect early signs of cancer spread from intestinal polyps. Researchers compared blood samples from 120 people with polyps to those without, looking for specific cells and proteins. The goal is to find better ways to monit…

This study tested a digital tool designed to help cancer survivors learn about and decide whether to get genetic testing for hereditary cancer risk. Researchers wanted to see if this smart technology was easy to use and if it encouraged more people to get tested. They compared th…

This study aimed to understand how often young endurance athletes develop colorectal cancer or precancerous growths. Researchers examined 94 athletes aged 35-50 who regularly ran long-distance races. They compared colonoscopy results from these athletes to average-risk people to …

This study aimed to understand and address why Latino individuals are underrepresented in cancer clinical trials. Researchers worked with 60 Spanish-speaking Latino adults from a local church, showing them educational videos about colorectal cancer and asking about their knowledg…

This study aimed to understand what causes colorectal polyps, which can lead to cancer. Researchers enrolled over 8,000 people scheduled for a routine colonoscopy. They collected health surveys, medical records, and samples like blood and tissue to compare people who had polyps w…

This study aimed to understand how drugs that affect the body's natural cannabis-like system (the endocannabinoid system) change how the colon's muscles contract. Researchers tested these drugs on small, healthy pieces of colon tissue taken from 36 patients during their scheduled…

This study aimed to understand how to improve digital tools for planning cancer care. Researchers observed and filmed 76 patients with colorectal cancer and their clinicians as they used an existing digital assessment tool and discussed care plans. The goal was to learn from thes…

This study looked at whether colorectal cancer patients need continued medical monitoring after five years of being cancer-free. Researchers analyzed data from 598 patients who had their tumors surgically removed with the goal of cure. The goal was to understand how often cancer …

This study aimed to understand how different social media messages influence people's plans to get screened for colorectal cancer. Researchers surveyed over 2,000 Black and White American adults, showing them different types of messages to see which ones made people more likely t…

This study tested two short questionnaires to see if they could predict which older patients (65+) with digestive cancers would experience severe side effects from chemotherapy. Researchers followed 72 patients to see if their scores on these frailty checklists matched up with wh…

This study aimed to see if providing educational materials about colorectal cancer screening would increase people's knowledge and encourage them to get screened. Researchers worked with 188 adults aged 45-75 in the Tampa Bay area, providing information on screening recommendatio…

This study looked at how the COVID-19 pandemic affected the diagnosis of colorectal cancer. Researchers analyzed 198 patients in Hungary to see if pandemic-related healthcare disruptions led to delays in diagnosis and more advanced cancer stages at detection. The goal was to unde…

This study aimed to see if a simple pre-surgery frailty test could predict which older patients are most likely to have complications after colorectal cancer surgery. Researchers followed 200 patients aged 65 and older, assessing their frailty before their operation and tracking …

This study aimed to find biological markers in blood and tumor tissue that could help predict how patients with esophageal or rectal cancer will respond to treatment before they start it. Researchers collected samples from 160 patients who were scheduled to receive chemotherapy a…

This study tested a training program called KanSurvive-ECHO to help rural primary care doctors provide better follow-up care for people who have finished treatment for breast, colorectal, lung, or prostate cancer. Researchers worked with 20 rural clinics to identify gaps in care …