Scientists uncover hidden electrical switch that fuels colorectal Cancer's spread

This study investigates how differences in cell membrane voltage, caused by varying physical pressures inside a tumor, help colorectal cancer resist chemotherapy and evade the immune system. Using advanced lab models and tissue samples from 11 patients, researchers found that cells at the tumor's edge are electrically active and aggressive, while core cells are suppressed but stress-adapted. The work identifies a key immune checkpoint, PVR/CD96, that could be targeted to restore immune attack. This is a basic science study, not a treatment trial, but it may guide future drug development.