Can High-Dose chemo make liver tumors operable?
NCT ID NCT00208260
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether more intense chemotherapy combinations could shrink liver tumors in people with colorectal cancer that cannot be fully removed by surgery. 124 participants received either standard two-drug chemo or one of three stronger regimens. The goal was to see if the stronger treatments would make the tumors small enough for surgery, while also tracking side effects and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chemotherapy (FOLFIRI, FOLFOX, FOLFIRINOX)
- What this could lead to
- If successful, this could show that more intense chemotherapy helps shrink liver tumors enough to allow surgical removal, potentially improving survival.
- What could go wrong
- This is an older, completed trial with only 124 participants, so results may not apply broadly. Stronger chemo also raises the risk of severe side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CRLC Val d'Aurelle
Montpellier, 34298, France
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