Can High-Dose chemo make liver tumors operable?
NCT ID NCT00208260
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether more intense chemotherapy combinations could shrink liver tumors in people with colorectal cancer that cannot be fully removed by surgery. 124 participants received either standard two-drug chemo or one of three stronger regimens. The goal was to see if the stronger treatments would make the tumors small enough for surgery, while also tracking side effects and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
chemotherapy (FOLFIRI, FOLFOX, FOLFIRINOX)
What this could lead to
If successful, this could show that more intense chemotherapy helps shrink liver tumors enough to allow surgical removal, potentially improving survival.
What could go wrong
This is an older, completed trial with only 124 participants, so results may not apply broadly. Stronger chemo also raises the risk of severe side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CRLC Val d'Aurelle
Montpellier, 34298, France