Exercise and creatine combo may restore strength in cancer survivors

NCT ID NCT06420726

Completed Symptom relief Sponsor: University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

Many colorectal cancer survivors lose muscle mass and strength after chemotherapy. This study tested whether adding creatine supplements to a 10-week resistance training program could help. Twenty-seven survivors participated, comparing those who took creatine with those who only exercised. The goal was to see if this combination is feasible and acceptable, and whether it improves muscle strength, physical function, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: creatine monohydrate
What this could lead to: If this approach works, it could offer a simple way to help colorectal cancer survivors rebuild muscle strength and physical function after chemotherapy.
What could go wrong: This is a small pilot study with only 27 participants, so results may not apply to everyone. The combination of exercise and supplements may not provide additional benefit over exercise alone.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

University of South Carolina

Columbia, South Carolina, 29201, United States

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