Lab study explores cannabis-like drugs for bowel disorders

NCT ID NCT05760404

Completed Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how drugs that interact with the endocannabinoid system (the body's natural cannabis-like system) affect the movement of colon muscle. Researchers took healthy tissue from 36 colorectal cancer patients during surgery and tested these drugs in the lab. The goal was to understand if these drugs could one day lead to new treatments for conditions like constipation, diarrhea, or irritable bowel syndrome.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: drugs acting on the endocannabinoid system (receptor modulators, enzyme inhibitors, transporter inhibitors)
What this could lead to: If successful, this research could point toward new treatments for bowel problems like constipation, diarrhea, or irritable bowel syndrome.
What could go wrong: This is a small, early lab study on tissue samples, not a clinical treatment trial. Results may not translate to real patients, and no drug is being tested in people yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COLORECTAL CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Fondazione Policlinico Universitario A. Gemelli, IRCCS

Roma, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.