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New cocktail of cancer drugs tested for Tough-to-Treat colorectal cancer

NCT ID NCT03377361

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a combination of nivolumab (Opdivo) and trametinib (Mekinist), with or without ipilimumab (Yervoy), in 325 people whose colorectal cancer had spread and had not responded to prior treatments. The main goals were to check safety and see if the drugs could shrink tumors. The trial has been completed, and results will help determine if this approach is worth further study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

nivolumab (Opdivo), trametinib (Mekinist), ipilimumab (Yervoy), regorafenib

What this could lead to

If successful, this combination could offer a new treatment option for people with advanced colorectal cancer that has not responded to prior therapy.

What could go wrong

This was an early-phase trial (Phase 1/2) focused on safety and dosing, so it is not yet clear if the combination works better than existing treatments. Side effects from combining these drugs may be significant.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER COLORECTAL CARCINOMA COLORECTAL NEOPLASM COLORECTAL TUMORS

Contacts and locations

Locations

  • Local Institution

    Woluwe-Saint-Lambert, 1200, Belgium

  • Local Institution - 0001

    San Francisco, California, 94158, United States

  • Local Institution - 0002

    Madison, Wisconsin, 53792-0001, United States

  • Local Institution - 0003

    Philadelphia, Pennsylvania, 19104, United States

  • Local Institution - 0004

    Hanover, 30625, Germany

  • Local Institution - 0022

    Birmingham, Alabama, 35249, United States

  • Local Institution - 0027

    Los Angeles, California, 90033, United States

  • Local Institution - 0028

    Baltimore, Maryland, 21287, United States

  • Local Institution - 0029

    Charlotte, North Carolina, 28204, United States

  • Local Institution - 0043

    Southport, Queensland, 4215, Australia

  • Local Institution - 0044

    Blacktown, New South Wales, 2148, Australia

  • Local Institution - 0051

    Madrid, 28041, Spain

  • Local Institution - 0052

    Barcelona, 08035, Spain

  • Local Institution - 0055

    Clayton, Victoria, 0, Australia

  • Local Institution - 0067

    Los Angeles, California, 90089, United States

  • Local Institution - 0068

    Elizabeth Vale, South Australia, 05112, Australia

  • Local Institution - 0069

    Heidelberg, Victoria, 3084, Australia

  • Local Institution - 0070

    Toronto, Ontario, M5G 2M9, Canada

  • Local Institution - 0071

    Brno, 65653, Czechia

  • Local Institution - 0072

    Olomouc, Olomouc Region, 779 00, Czechia

  • Local Institution - 0073

    Hradec Králové, 500 05, Czechia

  • Local Institution - 0076

    Ottawa, K1H 8L6, Canada

  • Local Institution - 0077

    Montreal, Quebec, H2X 0A9, Canada

  • Local Institution - 0079

    Badalona, Barcelona [Barcelona], 08916, Spain

  • Local Institution - 0080

    Pamplona, Navarre, 31009, Spain

  • Local Institution - 0092

    Padova, 35128, Italy

  • Local Institution - 0093

    Milan, 20133, Italy

  • Local Institution - 0094

    Rozzano, 20089, Italy

  • Local Institution - 0095

    Catania, 95124, Italy

  • Local Institution - 0096

    Seville, 41013, Spain

  • Local Institution - 0100

    Lancaster, Pennsylvania, 17604, United States

  • Local Institution - 0101

    Temple, Texas, 76508, United States

  • Local Institution - 0103

    St Louis, Missouri, 63110, United States

  • Local Institution - 0104

    New York, New York, 10016, United States

  • Local Institution - 0107

    Gainesville, Florida, 32610, United States

  • Local Institution - 0111

    Miami, Florida, 33136, United States

  • Local Institution - 0113

    Edmonton, Alberta, T6G 1Z2, Canada

  • Local Institution - 0114

    Madrid, 28007, Spain

  • Local Institution - 0115

    Madrid, 28050, Spain

  • Local Institution - 0116

    Hattiesburg, Mississippi, 39401-7233, United States

  • Local Institution - 0117

    Santiago, Santiago Metropolitan, 000000, Chile

  • Local Institution - 0118

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Local Institution - 0119

    Buenos Aires, 1431, Argentina

  • Local Institution - 0120

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

  • Local Institution - 0122

    Buenos Aires, Distrito Federal, C1096AAS, Argentina

  • Local Institution - 0123

    Buenos Aires, Distrito Federal, 1181, Argentina

  • Thomas Jefferson University - Clinical Research Institute

    Philadelphia, Pennsylvania, 19107, United States