New drug combo shrinks tumors in hard-to-treat GI cancers
NCT ID NCT03929666
First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 28 times
Summary
This study tested a new drug called ZW25 (zanidatamab) combined with standard chemotherapy in 74 people with advanced HER2-positive stomach, bile duct, or colorectal cancers. The goal was to see if the combination is safe and can shrink tumors. Results showed some patients had their tumors shrink, but the treatment is not a cure and ongoing management is needed.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Asan Medical Center
Seoul, 05505, South Korea
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CECIM Biocinetic
Santiago, 8320000, Chile
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Centro Internacional de Estudios Clínicos
Santiago, 8420383, Chile
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Centro de Investigacion Clinica SAGA
Santiago, 7500653, Chile
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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H. Lee Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92663, United States
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Icegclinic Research & Care
Santiago, 8241479, Chile
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Korea University Anam Hospital
Seoul, 02841, South Korea
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Nebraska Methodist Hospital
Omaha, Nebraska, 68114, United States
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Princess Margaret Cancer Center
Toronto, Ontario, M5G 2C1, Canada
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Pusan National University
Busan, 49241, South Korea
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital
Seoul, 03722, South Korea
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The Cancer and Hematology Centers
Grand Rapids, Michigan, 49503, United States
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The Ottawa Hospital Cancer Centre
Ottawa, Ontario, K1H 8L6, Canada
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USC/Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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Virginia Mason Medical Center
Seattle, Washington, 98101, United States
Conditions
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