COLORECTAL CANCER

This study tests whether a drug called QBECO, given as a self-injection before and after surgery, can lower the chance of colorectal cancer coming back or spreading in people with liver metastases. About 115 adults will take part, injecting the drug for at least 11 days before su…

This early-phase study tests an investigational drug called ABBV-400 in about 520 adults with advanced solid tumors, including lung, stomach, and colorectal cancers. The goal is to find the safest and most effective dose, either alone or combined with another drug (bevacizumab). …

This early-stage study tests a new drug called IMT-009 in people with advanced solid tumors or lymphomas that have not responded to standard treatments. The main goals are to find a safe dose and learn about side effects. About 67 participants will receive the drug intravenously,…

This early-phase study tests whether adding a personalized immune treatment to standard chemotherapy can prevent cancer from returning in colorectal cancer patients who have signs of remaining cancer cells (MRD-positive) after surgery. Ten adults aged 18-80 with stage II (high-ri…

This study was planned to test two drugs, Ezabenlimab and BI 907828, in people with advanced solid tumors like sarcoma, lung, breast, colorectal, or bile duct cancer. The goal was to see if the combination could control tumor growth for at least 24 weeks. However, the study was w…

This study tests a new drug (JAB-21822) combined with standard chemotherapy and bevacizumab in people with advanced colorectal cancer that has a specific KRAS G12C mutation. The goal is to see if this combination can shrink tumors or slow the disease in patients who have already …

This early-stage study tests a new drug called TORL-3-600 in 70 adults with advanced solid tumors or colorectal cancer. The main goals are to find a safe dose and check for side effects. Researchers will also see if the drug can shrink tumors or slow cancer growth.

This study tests an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors (like ovarian, breast, prostate, and lung cancer) that have stopped responding to standard treatments. The goal is to see if the drug is safe and tolerable when given alon…

This early-phase study tests an investigational cell therapy called P-MUC1C-ALLO1 in adults with advanced solid tumors (e.g., breast, ovarian, lung, pancreatic cancers) that have not responded to standard treatments. The main goals are to find a safe dose and check for early sign…

This program offers an unapproved drug, fruquintinib, to adults with metastatic colorectal cancer who have no other treatment options left. It is for compassionate use when standard therapies have failed and clinical trials are not possible. The goal is to provide access until th…

This study aimed to test whether two immunotherapy drugs (tiragolumab and atezolizumab) plus targeted radiation could help people with a specific, hard-to-treat type of advanced colorectal cancer called MSS mCRC. The trial was planned for adults aged 18 and older whose cancer had…

This early-phase study tests an experimental drug called M9140 in 12 Chinese adults with advanced colorectal cancer that has not responded to standard treatments. The drug is designed to deliver chemotherapy directly to cancer cells that carry a specific marker (CEACAM5). The mai…

This study looks at whether giving chemotherapy before and after surgery (plus heated chemotherapy inside the abdomen) helps people with colorectal cancer that has spread to the lining of the belly live longer compared to having surgery alone. About 358 adults with resectable tum…

This study looks at whether aerobic exercise can lower ctDNA levels in the blood, which may help prevent cancer from returning. About 33 people who have been treated for high-risk breast, prostate, or colorectal cancer will try different amounts of weekly exercise to find the saf…

This study tests a combination of three drugs (Tislelizumab, Fruquintinib, and Metronidazole) in 33 people with advanced colorectal cancer that has a high level of a specific gut bacteria called Fusobacterium nucleatum. The goal is to see if this treatment can slow or stop cancer…

This study looks at two methods of preparing the bowel before surgery for left-sided colorectal cancer. One group gets mechanical bowel prep alone, and the other gets mechanical prep plus oral antibiotics. The goal is to see if adding antibiotics reduces surgical site infections …

This study tests a combination of two drugs, cabozantinib and nivolumab, in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can stop or shrink the cancer for at least 16 weeks. About 48 adults with a spec…

This study looks at the best time to perform surgery after chemoradiation in patients with stage II or III rectal cancer. About 248 participants will receive radiation combined with chemotherapy drugs, then wait different lengths of time before surgery. The goal is to see which w…

This early-phase study tests a vaccine targeting mutant KRAS proteins, combined with two immunotherapy drugs (nivolumab and ipilimumab), in 27 patients with resected pancreatic or colorectal cancer. The goal is to see if the combination is safe and boosts the immune system's abil…

This study tests a combination of three drugs—fruquintinib, an immunotherapy (checkpoint inhibitor), and an oral chemotherapy (TAS-102)—in people with advanced colorectal cancer that has not responded to standard second-line treatments. The goal is to see if this combination can …

This early-stage trial tests a new treatment for people with advanced solid tumors (like head and neck, melanoma, or lung cancer). Doctors take a patient's own immune cells from the tumor, grow them into billions, and give them back as a one-time infusion. Some cells are also mod…

This study is for people with advanced colorectal cancer that has not responded to standard treatments. It compares two sequences of drugs: panitumumab followed by regorafenib, or the reverse order. The goal is to see which sequence helps patients live longer and controls the can…

This study is for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation, and whose cancer has worsened after standard treatments. The goal is to test the safety of combining two drugs, AVUTOMETINIB and cetuximab, and find the best dose. …

This study tests a new drug called MCLA-129 in people with advanced lung, stomach, esophageal, head/neck, or colorectal cancers that have not responded to standard treatments. The drug is a bispecific antibody designed to attack two cancer-related targets at once. The goal is to …

This study tests a new drug called XS-03 combined with standard chemotherapy and a targeted therapy (bevacizumab) in people with metastatic colorectal cancer that has a RAS mutation. About 102 adults aged 18-70 will take part. The goal is to see if the combination is safe and wor…

This early-phase study tests a new drug called LY4066434 in people with advanced solid tumors that have certain KRAS mutations. The main goal is to see if the drug is safe and tolerable when given alone or with other treatments. About 750 participants with pancreatic, lung, or co…

This study tests whether a new drug combination (XL092 plus atezolizumab) works better than the current standard drug regorafenib for people with advanced colorectal cancer that has spread and is no longer responding to other treatments. About 900 adults with a specific type of c…

This study looks at whether following a healthy diet can improve long-term survival and reduce the chance of cancer returning in people who have had colorectal cancer. About 500 participants with stage I to III colorectal cancer are taking part. Researchers are focusing on a diet…

This study is for people with advanced solid tumors (like lung, bladder, or skin cancer) whose disease has progressed after standard immunotherapy. It tests a new drug combination designed to boost the immune system to fight cancer. About 40 participants will receive the experime…

This study tests two experimental drugs, AK119 and AK112, alone or with chemotherapy, in 170 adults with a specific type of colorectal cancer (pMMR/MSS) that often doesn't respond well to standard treatments. The goal is to see if these combinations can shrink tumors or slow the …

This early-phase study tests the safety of a drug called tucatinib in about 25 Chinese patients with advanced HER2+ breast, stomach, or colorectal cancers that have stopped responding to standard treatments. The main goal is to see what side effects occur and how the drug moves t…

This study tests the drug pembrolizumab in 25 adults with a specific type of advanced colorectal cancer (dMMR) that cannot be surgically removed. The goal is to see if the drug can shrink tumors enough to allow surgery or avoid it altogether. Participants receive pembrolizumab an…

This study tests whether people with a specific type of advanced colorectal cancer (BRAF V600E mutation) can benefit from a second round of a targeted drug combination (encorafenib plus cetuximab). Only patients who previously responded well to the same drugs are eligible, and a …

This early-phase study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goal is to find the safest dose and check for side effects. About 44 adults who have tried other tre…

This study tests two drugs, botensilimab and balstilimab, in 16 people with advanced colorectal cancer that has spread. The goal is to see if the combination can shrink or stabilize tumors. If the cancer worsens, standard chemotherapy is added. Participants are followed for up to…

This early-phase trial tests a new drug called adagrasib (MRTX849) combined with two other drugs (cetuximab and irinotecan) in people with colorectal cancer that has a specific genetic change (KRAS G12C). The main goal is to find a safe dose and check for side effects. About 24 a…

This early-stage study is testing a new drug called ELVN-002 combined with trastuzumab (and sometimes chemotherapy) in adults with advanced HER2-positive solid tumors, including breast, colorectal, and gastric cancers. The main goals are to find the safest dose and understand sid…

This study aimed to see if immunotherapy drugs (nivolumab with or without ipilimumab) could help people with colorectal or gastroesophageal cancer avoid or delay major surgery. It planned to enroll adults with early-stage cancers. However, the study was withdrawn before any parti…

This study tests an experimental drug called HFB200603, alone or with another immunotherapy (tislelizumab), in adults with advanced solid tumors like kidney, lung, skin, stomach, or colorectal cancer. The goal is to find a safe dose and see how well the body tolerates it. About 8…

This study tests a new experimental drug (HR070803) added to standard chemotherapy and a targeted therapy for people with advanced colorectal cancer that has spread and cannot be removed by surgery. About 669 participants will receive either the new combination or the standard tr…

This study looks at whether adding a targeted treatment (local ablative therapy) to standard first-line chemotherapy can help people with colorectal cancer that has spread to a few spots (oligometastatic) live longer without the cancer getting worse. About 6 participants whose ca…

This early-phase trial tests a treatment for adults with certain advanced solid tumors (like colorectal, lung, or breast cancer) that have spread and stopped responding to standard therapy. The approach uses a person's own white blood cells, which are genetically modified in a la…

This study aimed to test whether adding the drug inavolisib to standard chemotherapy and bevacizumab could help people with a specific genetic form of advanced colorectal cancer (PIK3CA-mutated). It was designed for people who had not yet received treatment for their metastatic c…

This study tests a temporary device placed inside the bowel to protect the surgical connection after colorectal cancer surgery. The goal is to see if it can help patients avoid needing a temporary ileostomy (stoma bag) and reduce serious complications. About 108 adults having low…

This early-phase trial tests whether giving healthy donor NK cells along with two drugs (vactosertib and IL-2) is safe and helps the cells survive longer in people with advanced colorectal, stomach/esophageal, or blood cancers. About 12 participants will receive the combination t…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at higher risk of coming back after radiation alone. About 134 adults with cancers like melanoma, lung, breast, or colorectal cance…

This study tests an experimental immunotherapy called ELI-002 7P in people with pancreatic or other solid tumors that have specific KRAS or NRAS gene mutations. The treatment aims to help the immune system recognize and attack cancer cells after standard therapies like surgery an…

This study tests a drug called entrectinib in people with advanced solid tumors that have certain gene changes (NTRK, ROS1, or ALK). The drug aims to shrink or control the cancer by blocking these faulty genes. About 534 adults with various cancers, including lung, breast, and br…

This study tests a new drug called GDC-6036 in people with advanced cancers (like lung or colon cancer) that have a specific gene change called KRAS G12C. The goal is to find safe doses and see if the drug works alone or with other treatments. About 500 adults will take part in t…

This study tests whether adding extra stitches around the surgical connection (anastomosis) during laparoscopic low rectal cancer surgery can reduce the risk of leakage, a serious complication. About 300 adults with low rectal cancer will be assigned to either the standard proced…

This study tests whether a special low-calorie diet (fasting-mimicking diet) before and after surgery can help colorectal cancer patients recover faster and reduce the chance of cancer coming back. About 600 adults with stage III colorectal cancer will be followed for years. The …

This study planned to test two drugs, regorafenib and lorigerlimab, given before surgery to people with a certain type of colorectal cancer that had spread only to the lungs. The goal was to see if the combination was safe and could help shrink tumors. However, the trial was with…

This study tests a low dose of the immunotherapy drug nivolumab, alone or with chemotherapy, in people with advanced colorectal or stomach cancers that have a specific genetic feature (MSI/dMMR). The goal is to see if this approach can shrink tumors before surgery or control the …

This study tests whether taking low-dose aspirin daily can help prevent colorectal cancer from returning in patients whose tumors have certain gene mutations (PI3K pathway). The trial includes 626 people with stage II or III colon or rectal cancer who have had surgery. Researcher…

This early-phase study tests a new drug, AI-061, which combines two immunotherapy agents (anti-PD-1 and anti-CTLA-4) into one treatment for people with advanced solid tumors that have stopped responding to standard therapies. The main goal is to find the safest dose and check for…

This study tests a new combination of two immunotherapy drugs (MK-1308A) against other treatments for people with a specific type of advanced colorectal cancer (MSI-H/dMMR). The goal is to see if the new combo can shrink tumors or slow the disease. About 302 adults with stage IV …

This study tests a new drug called JDQ443, given alone or with other treatments, for people with advanced solid tumors that have a specific change in the KRAS gene (G12C). The goal is to find safe doses and see if the drug can shrink tumors. About 74 adults with lung or colorecta…

This study aimed to see if a person's own immune cells, modified in a lab to target specific cancer gene mutations, could prevent gastrointestinal cancers from coming back after standard treatment. It was designed for people with certain gene changes and blood markers suggesting …

This study compares two ways of giving chemotherapy directly into the abdomen after surgery for appendix or colorectal cancer that has spread to the lining of the belly. The goal is to see which method helps prevent cancer from coming back longer. About 292 adults who have had su…

This study tests two drugs, regorafenib and lorigerlimab, in people with high-risk colorectal cancer who have tiny traces of cancer DNA in their blood after finishing standard treatments. The goal is to see if this combination can safely clear those hidden cancer cells. The trial…

This early-phase study tests an experimental oral drug, HBI-2376, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have specific KRAS or EGFR gene mutations. The main goal is to find the safest dose and check for side effects. About 42 participan…

This study tests whether sending a colorectal cancer screening test directly to people's homes (without needing to order it) increases the number of people who get screened. About 64,000 adults aged 50-74 in central France will be randomly assigned to receive the test by mail or …

This study looks at whether a simple blood test that checks for tumor DNA can help decide which patients with diverticulitis (a colon inflammation) actually need a colonoscopy to rule out colorectal cancer. Researchers will collect blood from 220 patients and compare the test res…

This study tests a dye mixture (ICG and hyaluronic acid) that doctors inject into the colon wall near a tumor during a colonoscopy. During surgery, a special camera makes the dye glow, helping surgeons see exactly where the tumor is. The goal is to remove the right amount of tiss…

This study aims to see how well the LifeKit Prevent test finds colorectal cancer and precancerous polyps using a stool sample. About 12,000 adults aged 40 and older getting a routine screening colonoscopy will provide samples. The goal is to check if the test is accurate enough t…

This study looks at whether a stool-based test can accurately detect colorectal cancer and precancerous polyps in adults with cystic fibrosis, compared to the standard colonoscopy. About 350 participants will provide stool samples before their routine colonoscopy. The goal is to …

This study tests a combination of team-based clinic practices and patient-friendly technology to help more people complete a colonoscopy after an abnormal stool-based screening test. The goal is to catch colon cancer early or prevent it entirely. About 2,000 adults who speak Engl…

This study tests a digital program (mPATH-Cloud) that sends patients a text or letter inviting them to a website. On the site, they watch a short video about colorectal cancer screening options and can choose a stool test or colonoscopy. The goal is to see if this approach helps …

This study tests whether personalized screening—using stool tests, blood tests, and risk scores—can better prevent stomach and colon cancer in adults aged 50-75. Researchers will enroll 40,000 healthy participants and track them over time. The goal is to find the most effective w…

This study compares two common colorectal cancer screening methods: colonoscopy and an annual at-home stool test (FIT). Over 50,000 veterans aged 50-75 will be randomly assigned to one of the two screenings and followed for 10 years to see which approach better prevents deaths fr…

This study looks at whether taking a daily aspirin can reduce the risk of colorectal cancer in people who have already had precancerous polyps removed. About 180 adults aged 18 to 80 who had a colonoscopy in the last 9 months are taking part. Researchers are measuring certain che…

This study tests whether mailing colorectal cancer screening kits directly to patients can increase screening rates in underserved Brooklyn communities. About 3,000 adults aged 45-75 who are due for screening will receive a FIT test by mail and support to complete it. The goal is…

This study looks at whether taking low-dose aspirin can lower the risk of colorectal cancer in people who have already had polyps removed. About 161 adults aged 18-54 or 65+ who had a colonoscopy with polyp removal in the last 9 months are participating. Researchers will measure …

This large study is testing whether a screening procedure called flexible sigmoidoscopy can lower the number of colorectal cancer cases and deaths. About 100,000 men and women aged 50-64 in Norway are taking part. The study also looks at adding a stool blood test and how screenin…

This study tests whether sending reminders and using doctor's office nudges can encourage more people to get screened for colorectal cancer. About 20,000 adults aged 50-72 who are overdue for screening will take part. The goal is to see if these simple, low-cost approaches increa…

This study uses artificial intelligence to identify people aged 45-49 who may have a higher risk for colorectal cancer. Those identified as higher risk are offered help to complete a stool test or colonoscopy. The goal is to see if this approach increases screening rates and catc…

This study compares two screening methods—a stool test and a flexible tube exam—to see which works best for detecting colorectal cancer early. About 140,000 adults aged 50-74 in Norway are taking part. The goal is to find the most effective way to screen the population and reduce…

This study looks at whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer become more active while on chemotherapy. Participants will either do supervised or unsupervised aerobic and resistance exercises, or simpl…

This study tests a different way of taking the chemotherapy pill capecitabine for colorectal cancer. Instead of the standard schedule, patients take the drug for 7 days followed by 7 days off. The goal is to see if this pattern improves quality of life. About 100 patients with go…

This study looks at whether talking to an exercise specialist over the phone can help breast and colorectal cancer survivors become more physically active after finishing chemotherapy. Many people become less active during cancer treatment and struggle to return to their previous…

This study tests whether live exercise coaching plus a personalized digital app can improve quality of life for cancer survivors. About 146 adults with breast, lung, prostate, colorectal, or other cancers who had treatment in the last year will use the program for 18 months. Rese…

This study tests whether an internet-based cognitive therapy program, guided by a therapist, can reduce fear of cancer recurrence in colorectal cancer survivors. About 200 Danish adults who completed treatment for colorectal cancer without recurrence will participate. The program…

This study collects blood samples from 102 people with non-small cell lung cancer, colorectal cancer, or pancreatic cancer to track genetic changes in their tumors over time. Participants receive standard treatments, and researchers analyze DNA from the blood to see how it relate…

This study looks at 67 people in Denmark who had early-stage colorectal cancer removed during a colonoscopy or minor surgery. Doctors often recommend more surgery because of certain risk factors, but only about 15% of patients actually have leftover cancer. The researchers are te…

This study compares two surgical methods—keyhole (laparoscopic) and open—for emergency removal of part of the colon. About 192 adults needing urgent colon surgery will be randomly assigned to one technique. The goal is to see which approach leads to fewer complications and better…

This study collects tumor tissue from about 416 people with various advanced cancers to develop and train a new diagnostic platform called Elephas. The goal is to see how accurately the platform can predict whether a patient will respond to immunotherapy, compared to standard met…

This study looks at ways to help people who have inherited gene changes that raise cancer risk. It tests if certain tools can help them follow doctor guidelines for managing their cancer risk and share their genetic results with family members. About 720 adults with these gene ch…

This study aims to help rural clinics in Indiana get more people screened for colorectal cancer. Researchers will use methods like mailing test kits, sending text reminders, and assigning patient navigators to guide people through the process. The study involves clinic staff and …

This study looks at how well a stoma works and how it affects quality of life in people with colorectal cancer. It compares those who had emergency stoma surgery with those who had planned surgery. About 700 participants will fill out a questionnaire about their stoma function an…

This study collects tumor samples from over 3,000 adults with advanced cancers to look for specific genetic markers, called biomarkers. The goal is to help doctors choose the most promising targeted therapy or clinical trial for each patient. Participants do not receive a new tre…

This study looks at two new models of care for people who have finished treatment for early-stage breast or colorectal cancer. The goal is to see if these models help survivors get the recommended follow-up tests and preventive care they need. About 2,450 adults from Kaiser Perma…

This study reviews medical records from 700 adults with colorectal cancer that spread to the brain. Researchers will analyze which local treatments (like surgery or radiation) were used and how long patients lived or stayed free of brain tumor growth. No new treatments are given;…

This study looks at genetic markers in tumor tissue to see if they can predict how well two different chemotherapy combinations work for people with advanced colorectal cancer. About 757 patients who have not had chemotherapy before will be randomly assigned to one of two treatme…

This study tests whether a special 'figure-of-X' stitching pattern is better than the usual continuous stitch for closing the abdominal wall after colorectal surgery. The goal is to see if it reduces the chance of the wound bursting open, a serious complication. About 40 adults h…

This study looks at whether providing education materials helps relatives of people with Lynch syndrome decide about genetic counseling and testing. About 185 adult relatives will be randomly assigned to receive either a standard information letter or a letter plus a booklet. Res…

This study gathers information from 1500 people with inherited conditions that cause many colon polyps and raise cancer risk. Researchers will track how the disease develops, what treatments people receive, and their long-term health. The goal is to create better guidelines and r…

This study looks at whether a simple blood test can find tiny bits of cancer DNA left in the body after surgery for stage II or III colorectal cancer. Over 1,000 participants will be followed for up to 7 years to see if the test can predict cancer coming back earlier than standar…

This study tests a program called CARES-REACH to help more people in rural clinics get screened for colorectal cancer. Researchers will track how many patients complete a simple at-home stool test (FIT) and see what factors affect screening rates. The goal is to find better ways …

This study aimed to see if certain genes that make people more prone to bleeding could cause a stool test for colon cancer to show a false-positive result. Researchers planned to collect saliva samples from people who had a positive stool test but a normal colonoscopy, and compar…

This study looks at whether a simple blood test can find tiny bits of cancer DNA left behind after surgery for colorectal cancer. Over 3,000 patients who had their cancer removed will give blood samples to see if the test can predict who is at high risk of the cancer coming back.…

This study tests whether giving doctors real-time feedback during colonoscopy helps them find more polyps, which can prevent colorectal cancer. Over 4,000 doctors will participate. The goal is to see if this simple approach improves the quality of the exam.

This study looks at how Western habits—like drinking alcohol and eating late—might increase the risk of colorectal cancer. Twelve adults who previously had colon polyps will try four different weekly routines (eating at normal times vs. late, with or without alcohol). Researchers…

This study looks at tissue samples from 582 people with colon cancer, colon polyps, or healthy colons to find molecular markers linked to cancer development. Researchers are testing for gene mutations, protein changes, and gut bacteria differences. The goal is to better understan…

This study planned to test three advanced imaging techniques to help surgeons spot colorectal cancer cells more clearly during operations. The goal was to see if these methods could improve how completely tumors are removed. However, the study was withdrawn before any participant…

This study follows 637 people with a specific type of colorectal cancer called MSI. Researchers are collecting medical records and tumor samples to find patterns that predict whether the cancer will come back or respond to chemotherapy. No new treatments are given; the goal is to…

This study tests whether a nurse-led health coaching program helps women aged 45 to 64 in Hong Kong use medical services more wisely and feel more in control of their health. About 1,728 women will either receive the nurse coaching or general health advice. The goal is to see if …

This pilot study compares two stool-based tests, Cologuard and FIT, sent by mail to adults ages 45-49 who are not up-to-date with colorectal cancer screening. The goal is to see which test leads to more people completing screening and following up on abnormal results. About 100 p…

This study looks at gene changes in tumor tissue from 787 people with advanced or recurrent colorectal cancer who took part in the earlier PARADIGM trial. Researchers want to see how these gene changes relate to how long patients lived or how long their cancer stayed under contro…

This study looks at whether special blood tests can help doctors tell if treatment is working and if cancer will come back in people with colorectal cancer that has spread to a few spots in the liver or lungs. Researchers will collect blood samples from 120 patients before, durin…

This study follows about 64,000 adults who grew up on farms to see if early exposure to pesticides and other farm-related factors is linked to cancer. Participants fill out a questionnaire and may provide blood or other samples. The goal is to understand how childhood agricultura…

This study looks at how offering a choice of screening methods and culturally tailored information can help more African Americans complete colorectal cancer screening. About 600 eligible adults from health centers in Michigan will pick a screening option and then receive either …