COLORECTAL CANCER

This is the first time researchers are testing the experimental drug TORL-3-600 in people. The study aims to find a safe dose and see how the body handles the drug in 70 patients with advanced solid tumors, including colorectal cancer. It is an early safety study, not a cure, and…

This early-stage study is testing a new oral medication called HBI-2376 in people with advanced solid tumors that have specific KRAS or EGFR mutations. The main goals are to find the highest safe dose of the drug and to understand how the body absorbs and processes it. The trial …

This early-stage trial is testing the safety and best dose of a new drug, adagrasib, when combined with two existing cancer drugs (cetuximab and irinotecan). It is for adults with advanced colorectal cancer that has a specific genetic change called KRAS G12C and has stopped respo…

This study is testing whether following specific healthy eating guidelines for many years can help people live longer and prevent their colorectal cancer from coming back after surgery. About 500 patients who had surgery for early-stage colorectal cancer are participating. One gr…

This study tests whether combining three different types of cancer drugs can help people with advanced colorectal cancer that has stopped responding to standard treatments. Researchers will give patients a targeted therapy, an immunotherapy, and an oral chemotherapy together or i…

This study is testing whether a new two-drug combination (MK-1308A) works better than other treatments for people with advanced colorectal cancer that has spread and has specific genetic features (MSI-H/dMMR). The trial involves 302 participants who either haven't received treatm…

This study tested whether regular phone calls from an exercise coach could help people who recently finished treatment for early-stage breast or colorectal cancer become more physically active. Research suggests staying active after cancer may lower the chance of the cancer comin…

This study aimed to test the safety and effectiveness of a two-drug combination (Ezabenlimab and BI 907828) for people with advanced, hard-to-treat cancers that had spread. It was designed for adults with specific types of soft tissue sarcoma, lung, breast, colorectal, or biliary…

This early-stage study aims to check the safety and understand how the body processes the drug tucatinib in a small group of Chinese patients. It includes people with advanced breast, stomach, or colorectal cancers that have a specific marker called HER2+ and have stopped respond…

This study is testing whether a daily low-dose aspirin pill can help prevent colorectal cancer from returning after surgery. It focuses on patients whose tumors have specific genetic changes in the PI3K pathway. Participants take either aspirin or a placebo pill daily for three y…

This trial is testing a new immunotherapy called ELI-002 7P. It is for people with pancreatic or colorectal cancer that has a specific genetic change (KRAS or NRAS mutation) and who have already had surgery and chemotherapy. The goal is to see if this treatment can safely help th…

This study aimed to test a new combination treatment for advanced colon cancer that has spread and is resistant to standard immunotherapies. It planned to give patients two immunotherapy drugs (tiragolumab and atezolizumab) along with a short, targeted course of radiation. The go…

This is the first human study of an experimental oral medication called HBI-2438 for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find the highest safe dose and understand how the body processes the drug. The study …

This is an early safety study testing a new cancer drug called M9140 in Chinese patients with advanced colorectal cancer that has stopped responding to standard treatments. The trial will enroll 12 participants to check if the drug is safe and to see early signs of whether it mig…

This study is testing a new combination of immune-boosting drugs for people with advanced cancers whose disease has progressed after treatment with standard immunotherapies like pembrolizumab or nivolumab. It aims to see if adding a drug called NAI to other treatments can help sh…

This study is testing if a different schedule for the chemotherapy drug capecitabine can improve quality of life for people with colorectal cancer. It compares a '7 days on, 7 days off' schedule to the standard regimen. The main goal is to see if this new schedule helps patients …

This study is testing if a specific drug combination (encorafenib plus cetuximab) can work a second time for patients with a certain type of advanced colorectal cancer. It will enroll 16 patients whose cancer initially responded to this same treatment but later stopped working. D…

This early-stage study is testing a new drug called MCLA-129, which is designed to attack cancer cells by blocking two different growth signals at once. It is for adults with advanced lung, stomach, head/neck, or other solid tumors that have stopped responding to standard treatme…

This study is testing whether a combination of two drugs, regorafenib and lorigerlimab, can clear tiny traces of cancer left in the blood after standard treatment for colorectal cancer. The goal is to see if this treatment can prevent the cancer from coming back in patients who s…

This large study is testing whether adding a new drug called HR070803 to standard chemotherapy works better for people with advanced colorectal cancer that has spread and cannot be removed by surgery. About 669 patients will receive either the new combination or the current stand…

This study is testing a new targeted drug called JAB-21822 for Chinese patients with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The drug is combined with standard second-line chemotherapy and another cancer drug (bevacizumab) after initial tre…

This study is testing whether waiting different lengths of time between completing chemo-radiation treatment and having surgery improves outcomes for people with stage II or III rectal cancer. Researchers are looking to see if a longer wait helps eliminate more cancer cells befor…

This study aims to help more people complete a necessary colonoscopy after an abnormal stool test for colorectal cancer. It tests a two-part program: training clinic teams in best practices and providing patients with tech tools for instructions and scheduling help. The goal is t…

This study aims to find the best order to give two different cancer drugs to patients with advanced colorectal cancer that has stopped responding to standard treatments. Researchers are comparing whether starting with panitumumab followed by regorafenib works better than the reve…

This program provided compassionate early access to the drug fruquintinib for adults with advanced colorectal cancer that had stopped responding to all standard treatments. Participants took oral capsules in repeating cycles. The goal was to control the cancer and extend life whe…

This study is testing whether a combination of two drugs, cabozantinib and nivolumab, can help control advanced colorectal cancer that has stopped responding to standard treatments. It will involve about 48 adults whose cancer has spread and is a specific type called microsatelli…

This study is testing whether adding an experimental drug called XS-03 to standard chemotherapy combinations helps control metastatic colorectal cancer that has a specific genetic change called a RAS mutation. The trial will first find the safest dose of XS-03, then see if the ne…

This study is testing a drug called entrectinib for people with advanced solid tumors that have specific genetic changes (NTRK, ROS1, or ALK gene rearrangements). It's a 'basket trial,' meaning it groups patients by their tumor's genetic type rather than where the cancer started …

This study aimed to test if a personalized immune cell therapy could prevent or delay the return of advanced gastrointestinal cancers (like pancreatic, liver, or colon cancer) after standard treatment like surgery. It was for patients whose cancer had specific genetic mutations a…

This study is testing whether a structured physical activity program can help prevent colon cancer from coming back in people who have already had surgery and chemotherapy. It will compare a group that gets the exercise program plus health education to a group that gets health ed…

This early-stage study is testing a personalized vaccine designed to target specific mutations found in colorectal and pancreatic cancers. The vaccine is combined with two immunotherapy drugs (nivolumab and ipilimumab) to help the body's immune system recognize and attack cancer …

This is a first-in-human study testing a new personalized cell therapy for people with advanced solid tumors that have not responded to standard treatments. Doctors take a patient's own tumor-fighting immune cells from a tumor sample, grow large numbers of the most potent ones in…

This is an early-stage study to find a safe dose of a new immunotherapy drug called HFB200603. It will be tested alone and in combination with an existing drug, tislelizumab, in 83 adults with advanced solid tumors like lung, kidney, or skin cancer. The main goal is to check for …

This study is comparing two methods of delivering heated chemotherapy directly into the abdomen after surgery for appendix or colorectal cancer that has spread there. About 292 patients will be randomly assigned to receive either chemotherapy right after surgery or a heated versi…

This study aimed to see if approved immunotherapy drugs (nivolumab with or without ipilimumab) could help people with early-stage colorectal or gastroesophageal cancer delay or avoid major surgery to remove their tumors. The goal was an 'organ preservation' strategy, using the dr…

This is the first study in people to test the safety and early effectiveness of an investigational drug called ABBV-400 for adults with advanced solid tumors that have stopped responding to standard treatments. The study will find the best dose of ABBV-400 given alone and will al…

This study is testing whether a new two-drug combination (XL092 + atezolizumab) works better than the current standard drug (regorafenib) for people with advanced colorectal cancer that has spread and stopped responding to other treatments. It involves about 900 participants whos…

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This is a first-in-human study testing a new type of cancer treatment called P-MUC1C-ALLO1 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how well the body tolerates this 'off-the-shelf' CAR-T …

This study is testing new drug combinations for people with advanced colorectal cancer that hasn't responded to standard treatments. Researchers are examining two experimental drugs, AK119 and AK112, given alone, together, or with chemotherapy, to see if they can better control t…

This small, early-stage study is testing a new treatment approach for people with advanced colorectal cancer that has not spread to the liver, bones, or brain. Participants first receive a combination of two immunotherapy drugs. If their cancer grows, standard chemotherapy is add…

This study is testing whether a combination of three drugs can help control advanced colorectal cancer that has stopped responding to standard treatments. It is for patients with a specific type of cancer and a certain gut bacteria. The main goal is to see if this new approach ca…

This study is testing whether the immunotherapy drug pembrolizumab can shrink tumors in people with a specific type of locally advanced colon cancer that cannot be surgically removed. It will involve 25 participants who will receive the drug intravenously every three weeks. The m…

This early-stage study is testing whether immune cells from healthy donors, given along with two other drugs, are safe for people with advanced colorectal, stomach, or hard-to-treat blood cancers. The goal is to see if this combination helps the donor immune cells last longer in …

This early-stage study is testing the safety and best dose of a new drug, ELVN-002, when given with standard treatments for advanced HER2-positive cancers. It will involve about 275 adults with cancers like breast, colorectal, or gastric cancer that have spread or returned after …

This is an early-stage trial to test the safety and determine the right dose of a new experimental drug called LY4066434. The drug is designed to block a common cancer-driving protein called KRAS in people with advanced solid tumors, including pancreatic, lung, and colorectal can…

This study is testing whether a medication called QBECO, given as injections before and after surgery to remove colorectal cancer that has spread to the liver, can help keep the cancer from coming back. About 115 participants will receive either QBECO or a placebo (inactive subst…

This study aimed to test a two-drug combination (regorafenib and lorigerlimab) given before surgery to patients with colorectal cancer that had spread only to the lungs. The goal was to see if the treatment was safe and could shrink the lung tumors to make surgery more effective.…

This is an early-stage study testing a new antibody drug called IMT-009 in people with advanced solid tumors or lymphomas that have stopped responding to standard treatments. The main goals are to find a safe dose, understand the side effects, and see if the drug helps shrink tum…

This study is testing new drug combinations for people with advanced solid tumors that have a specific genetic change called KRAS G12C. It focuses on patients with non-small cell lung cancer or colorectal cancer who have already tried standard treatments. The main goals are to fi…

This study is testing two different ways to provide follow-up care for people who have finished treatment for early-stage breast or colorectal cancer. It compares the usual cancer specialist care to a new model where a primary care doctor works right in the cancer clinic. The goa…

This is an early-stage study to find a safe dose and see how the body processes a new drug called GDC-6036. It is being tested alone and with other cancer drugs in people with advanced solid tumors, like lung or colorectal cancer, that have a specific genetic change called KRAS G…

This study is comparing two ways of reconnecting the bowel during surgery for low rectal cancer. One method is the standard approach, and the other adds 8-10 extra stitches to reinforce the connection. The goal is to see if the reinforced method is better at preventing a serious …

This study was designed to test whether adding a new drug called inavolisib to standard chemotherapy could better control advanced colorectal cancer that has spread and has a specific genetic change (PIK3CA mutation). It was intended for people who had not yet received treatment …

This study is testing a temporary internal device called Colovac, which is placed inside the bowel during colorectal cancer surgery. The goal is to protect the new connection (anastomosis) so more patients can heal without needing an external ostomy bag. Researchers will enroll 1…

This is an early safety study testing a new cancer vaccine called PeptiCRAd-1, given alongside the immunotherapy drug pembrolizumab. It aims to see if this combination is safe and can activate the immune system to fight cancer in patients with advanced solid tumors that have stop…

This study is testing whether a simple blood test can help decide which patients need a colonoscopy after a diverticulitis episode. Currently, guidelines recommend a colonoscopy for everyone with diverticulitis to rule out colorectal cancer, but cancer is found in less than 2% of…

This study is testing whether giving doctors real-time feedback during a colonoscopy helps them find more precancerous growths called adenomas. It involves over 4,000 colonoscopies performed by participating doctors. The goal is to improve the quality of colorectal cancer screeni…

This study is testing whether two types of at-home stool tests can be as effective as a colonoscopy for detecting colon cancer and pre-cancerous growths in adults with cystic fibrosis. 350 participants who are already scheduled for a routine colonoscopy will collect stool samples…

This study aims to see how well a new at-home stool test, called LifeKit Prevent, can detect colon cancer and precancerous growths (polyps). Researchers will enroll 12,000 adults aged 40+ who are already scheduled for a screening colonoscopy. Participants will use the new test an…

This study is testing whether mailing colon cancer screening kits directly to people's homes increases how many people get screened. Researchers are comparing two different mailing approaches against the current invitation system in France. The trial involves 64,000 people aged 5…

This study is testing a blood test that looks for tiny bits of cancer DNA after surgery for colon or rectal cancer. The goal is to see if this test can accurately predict whose cancer is likely to come back. If successful, it could help doctors give extra chemotherapy only to the…

This early study is testing a new fluorescent dye called VGT-309 to see if it is safe and can help doctors better see cancerous spots during a colonoscopy. It will involve about 15 adults who already have confirmed colorectal cancer and are scheduled for a standard colonoscopy. T…

This study is testing a new glowing marker called Luminomark to help surgeons find early-stage colon cancers more accurately during surgery. Before surgery, doctors inject the special dye near the tumor during a colonoscopy. During the operation, surgeons use a special camera tha…

This study is testing whether taking a daily low-dose aspirin pill can help prevent colorectal cancer in people who have had precancerous polyps removed. About 160 participants will take either aspirin or a placebo pill daily for a set period while researchers analyze blood, urin…

This study is testing if a computer program (AI) can better identify 45 to 49-year-olds who are behind on colon cancer screening and might be at higher risk. Those flagged by the AI will be offered extra help from a patient navigator to complete either a stool test or a colonosco…

This large study is testing personalized screening strategies to prevent stomach and colorectal cancers. It will enroll 40,000 healthy adults aged 50-75 to see if combining specific tests can better identify people at highest risk. The goal is to guide more effective screening an…

This study is testing whether taking a daily aspirin pill can help prevent colorectal cancer in people who are at higher risk because they've had precancerous polyps removed. Researchers are comparing a low-dose aspirin, a regular-dose aspirin, and a placebo (sugar pill) in 180 a…

This study aims to help more African American adults get screened for colon cancer. It tests whether letting people choose their preferred screening test (like a colonoscopy or an at-home kit) and then giving them a culturally tailored plan to follow through increases completion …

This study is testing if adding oral antibiotics to the standard bowel-cleaning routine before surgery for left-sided colon cancer helps prevent infections at the surgical site. It will involve 60 adult patients scheduled for elective surgery. Researchers want to see if this comb…

This study aims to increase colon cancer screening rates in underserved Brooklyn communities by proactively mailing at-home stool test kits to eligible patients. The research will test whether this organized outreach, combined with support navigation, helps more people complete r…

This large study aims to find out which screening method is better at preventing deaths from colorectal cancer: a one-time colonoscopy or an annual at-home stool test (FIT). It enrolled over 50,000 veterans aged 50-75 who were due for routine screening. Researchers will follow pa…

This pilot study aims to find out if mailing a Cologuard test kit or a simpler FIT test kit is more effective at getting people to complete colon cancer screening. It involves 100 adults aged 45-49 who are not up-to-date with their screening. Researchers will measure how many peo…

This study is testing whether regular aerobic exercise can prevent cancer from returning in people who have already been treated. Researchers are working with 33 people who have had breast, prostate, or colorectal cancer to find the right amount of weekly exercise that safely low…

This study is testing a program to help more people get screened for colon cancer. It will send text reminders to 20,000 patients who are overdue for screening and give their doctors alerts during appointments. The goal is to see if these simple nudges can get more people to comp…

This study is testing whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer stay more active and protect their heart health while they undergo chemotherapy. About 135 participants are randomly assigned to try eith…

This study tests whether a therapist-supported online therapy program can help reduce the fear of cancer returning in people who have survived colorectal cancer. It compares the online program to standard care. The goal is to see if this accessible, internet-based approach can im…

This study is testing whether a personalized mobile app with live coaching can improve quality of life for people who have had cancer. The 18-month program focuses on exercise, meditation, and diet advice. Researchers will compare the app's coaching to standard lifestyle resource…

This study aims to understand how modern lifestyle habits, specifically drinking alcohol and eating meals at irregular or late times, might increase a person's risk for colorectal cancer. Researchers are studying 12 adults who have had certain colon polyps, having them follow dif…

This study aims to better understand the safety of standard colorectal cancer surgery by tracking how often major complications occur. Researchers will follow 132 adult patients who are having surgery that requires a temporary ileostomy bag. The data collected will help create a …

This study is observing 637 patients with a specific genetic type of colorectal cancer called MSI. The goal is to collect detailed information to better understand how this cancer behaves, which treatments work best, and what factors predict patient outcomes. It is an observation…

This study is testing whether educational materials help relatives of people with Lynch syndrome decide about getting genetic counseling and testing. About 185 relatives at risk will receive either a standard information letter or the letter plus an educational booklet. Researche…

This study aimed to understand why some people get a positive result on a common stool test for colon cancer, but then a follow-up colonoscopy finds nothing wrong. Researchers wanted to check if a person's genetic tendency to bleed a little more easily could cause these 'false po…

This study aims to understand whether exposure to farm environments during childhood increases the risk of developing cancer and other diseases in adulthood. Researchers are following over 64,000 adults who grew up on farms, collecting health information and biological samples ov…

This study looks back at the medical records of 700 patients from Russia and Belarus to understand which treatments work best when colorectal cancer spreads to the brain. Researchers are analyzing past surgeries and radiation therapies to see which approaches helped patients live…

This study is testing whether a blood test can predict if colorectal cancer will come back after surgery. It involves 1,017 people who have had surgery for stage II or III colorectal cancer. Researchers will follow participants for up to 7 years to see if tiny amounts of cancer D…

This study aims to help doctors choose the best future treatments for patients with advanced cancers. Researchers are analyzing stored tumor samples from over 3,000 patients to look for specific genetic markers. The goal is to create a personalized profile for each patient's canc…

This study is creating a national Italian registry to track patients with inherited conditions that cause many colon polyps and high cancer risk. It will follow about 1,500 patients to collect detailed information on how their disease progresses, what treatments they receive, and…

This study aims to learn how tracking cancer DNA in the blood relates to treatment response. It will observe 102 adults with lung, colorectal, or pancreatic cancer who are receiving standard care. Researchers will collect blood samples over time to see if changes in cancer DNA le…

This study aims to understand how a specific program helps increase colon cancer screening rates, especially in rural areas. It does not involve treating patients; instead, it collects information from healthcare providers and clinics. The goal is to learn which clinic procedures…

This study is analyzing existing data from a previous trial to learn how specific genetic changes in tumors relate to how long patients with advanced or returning colorectal cancer live and how long their cancer stays controlled. Researchers are looking at tumor tissue and blood …

This study is testing different online tools to help people who have inherited a gene change that increases cancer risk. It aims to help them better share this important information with their family members and follow the recommended cancer screening and prevention guidelines. T…