Can a common drug stop Chemo's nerve pain?
NCT ID NCT03722680
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests whether riluzole, a drug used for ALS, can prevent nerve damage caused by oxaliplatin chemotherapy in people with stage II/III colorectal cancer. About 80 participants will receive either riluzole or a placebo during their chemo. The study is currently suspended, so results are not yet available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
riluzole
What this could lead to
If it works, this could point toward a way to prevent nerve damage from oxaliplatin chemotherapy, helping patients avoid pain and numbness.
What could go wrong
This is a small, early-phase trial that is currently suspended, so results may not be reliable. The drug may not prevent nerve damage or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CH Annecy-Genevois
Pringy, France
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CH Beauvais
Beauvais, France
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CHU de Clermont -Ferrand
Clermont-Ferrand, France
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CHU de Dijon
Dijon, France
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CHU de Reims
Reims, France
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CHU de Saint-Etienne
Saint-Priest, France
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Centre François Baclesse
Caen, France
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Centre Georges François Leclerc
Dijon, France
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Clinique St Côme
Compiègne, France
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GHPSO
Creil, France
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Hia Begin
Saint-Mandé, France
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Hia Percy
Clamart, France
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Hôpital Foch
Suresnes, France
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ICO - Site Paul Papin
Angers, France
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ICO - Site René Gauducheau
Saint-Herblain, France
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Institut Jean Godinot
Reims, France