New hope for Tough-to-Treat colorectal cancer?

NCT ID NCT05425940

Ongoing Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether a new drug combination (XL092 plus atezolizumab) works better than the current standard drug regorafenib for people with advanced colorectal cancer that has not responded to other treatments. About 900 participants will receive either the new combo or regorafenib. The main goal is to see if the new combo helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: XL092 and atezolizumab (Tecentriq)
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced colorectal cancer who have run out of standard therapies, potentially extending survival.
What could go wrong: This is a large phase 3 trial, but the experimental drug combination may not prove better than the existing drug regorafenib. Side effects from the combination could be significant.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Exelixis Clinical Site #1

Omaha, Nebraska, 68130, United States
Exelixis Clinical Site #10

Westwood, Kansas, 66205, United States
Exelixis Clinical Site #100

Singapore, 168583, Singapore
Exelixis Clinical Site #101

Tainan, 704, Taiwan
Exelixis Clinical Site #102

Indianapolis, Indiana, 46250, United States
Exelixis Clinical Site #103

Pittsburgh, Pennsylvania, 15232, United States
Exelixis Clinical Site #104

Wellington, 6021, New Zealand
Exelixis Clinical Site #105

Orange, California, 92868, United States
Exelixis Clinical Site #106

Philadelphia, Pennsylvania, 19107, United States
Exelixis Clinical Site #107

Kaohsiung City, 833, Taiwan
Exelixis Clinical Site #108

Almada, 2805-267, Portugal
Exelixis Clinical Site #109

Dresden, 01307, Germany
Exelixis Clinical Site #11

New York, New York, 10016, United States
Exelixis Clinical Site #110

Birmingham, B95SS, United Kingdom
Exelixis Clinical Site #111

Edinburgh, EH42XU, United Kingdom
Exelixis Clinical Site #112

Barcelona, 08908, Spain
Exelixis Clinical Site #113

Frankfurt am Main, 60488, Germany
Exelixis Clinical Site #114

London, W1G 6AD, United Kingdom
Exelixis Clinical Site #115

Romford, RM70AG, United Kingdom
Exelixis Clinical Site #116

Madrid, 28007, Spain
Exelixis Clinical Site #117

Bedford Park, 5042, Australia
Exelixis Clinical Site #118

Liuying, 73657, Taiwan
Exelixis Clinical Site #119

Guishan, 333, Taiwan
Exelixis Clinical Site #12

Oklahoma City, Oklahoma, 73142, United States
Exelixis Clinical Site #120

Coimbra, 3000-075, Portugal
Exelixis Clinical Site #121

Zaragoza, 50009, Spain
Exelixis Clinical Site #122

Győr, 9024, Hungary
Exelixis Clinical Site #123

London, EC1A 7BE, United Kingdom
Exelixis Clinical Site #124

Lisbon, 1649-035, Portugal
Exelixis Clinical Site #125

New Haven, Connecticut, 06510, United States
Exelixis Clinical Site #126

Sutton, SM2 5PT, United Kingdom
Exelixis Clinical Site #127

Hanover, Niedersach, 30625, Germany
Exelixis Clinical Site #128

Nyíregyháza, Szabolcs-Szatmar-Bereg County, 4400, Hungary
Exelixis Clinical Site #129

Budapest, 1122, Hungary
Exelixis Clinical Site #13

Seattle, Washington, 98101, United States
Exelixis Clinical Site #130

Bristol, England, BS2 8ED, United Kingdom
Exelixis Clinical Site #131

Lisbon, 1500-650, Portugal
Exelixis Clinical Site #132

Singapore, 119228, Singapore
Exelixis Clinical Site #133

Nashville, Tennessee, 37232, United States
Exelixis Clinical Site #14

Roanoke, Virginia, 24014, United States
Exelixis Clinical Site #15

Albuquerque, New Mexico, 87131, United States
Exelixis Clinical Site #16

Miami Beach, Florida, 33140, United States
Exelixis Clinical Site #17

The Bronx, New York, 10461, United States
Exelixis Clinical Site #18

Pittsburgh, Pennsylvania, 15212, United States
Exelixis Clinical Site #19

Melbourne, 3002, Australia
Exelixis Clinical Site #2

Spokane, Washington, 99208, United States
Exelixis Clinical Site #20

Bydgoszcz, 85-796, Poland
Exelixis Clinical Site #21

Barcelona, 08025, Spain
Exelixis Clinical Site #22

St Louis, Missouri, 63141, United States
Exelixis Clinical Site #23

Melbourne, 3021, Australia
Exelixis Clinical Site #24

Greenville, South Carolina, 29607, United States
Exelixis Clinical Site #25

Hong Kong, Hong Kong
Exelixis Clinical Site #26

Siedlce, 08-110, Poland
Exelixis Clinical Site #27

Port Macquarie, 2444, Australia
Exelixis Clinical Site #28

Hwasun, 58128, South Korea
Exelixis Clinical Site #29

Gyeonggi-do, 14068, South Korea
Exelixis Clinical Site #3

Joliet, Illinois, 60435, United States
Exelixis Clinical Site #30

Phoenix, Arizona, 85004, United States
Exelixis Clinical Site #31

Warsaw, 02-507, Poland
Exelixis Clinical Site #32

Seattle, Washington, 98104, United States
Exelixis Clinical Site #33

Hong Kong, Hong Kong
Exelixis Clinical Site #34

Seoul, 03080, South Korea
Exelixis Clinical Site #35

Namur, 5000, Belgium
Exelixis Clinical Site #36

Goyang-si, 10408, South Korea
Exelixis Clinical Site #37

Seongnam-si, 13620, South Korea
Exelixis Clinical Site #38

Paris, 75020, France
Exelixis Clinical Site #39

Singapore, 217562, Singapore
Exelixis Clinical Site #4

Marietta, Georgia, 30060, United States
Exelixis Clinical Site #40

Seoul, South Korea
Exelixis Clinical Site #41

Budapest, 1097, Hungary
Exelixis Clinical Site #42

Tomaszów Mazowiecki, 97-200, Poland
Exelixis Clinical Site #43

Antwerp, 2300, Belgium
Exelixis Clinical Site #44

Seoul, 08308, South Korea
Exelixis Clinical Site #45

Seoul, 03722, South Korea
Exelixis Clinical Site #450

Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #46

Seoul, 06351, South Korea
Exelixis Clinical Site #47

Lexington, Kentucky, 40536, United States
Exelixis Clinical Site #48

Debrecen, 4302, Hungary
Exelixis Clinical Site #49

Dunedin, 9016, New Zealand
Exelixis Clinical Site #5

Santa Rosa, California, 95403, United States
Exelixis Clinical Site #51

Brussels, 1200, Belgium
Exelixis Clinical Site #52

Besançon, 25030, France
Exelixis Clinical Site #53

Bankstown, 2200, Australia
Exelixis Clinical Site #54

Seoul, 06591, South Korea
Exelixis Clinical Site #55

La Jolla, California, 92037, United States
Exelixis Clinical Site #56

Chattanooga, Tennessee, 37404, United States
Exelixis Clinical Site #57

Auckland, 1023, New Zealand
Exelixis Clinical Site #58

Torrance, California, 90505, United States
Exelixis Clinical Site #59

New York, New York, 10029, United States
Exelixis Clinical Site #6

Cincinnati, Ohio, 45219, United States
Exelixis Clinical Site #60

Orlando, Florida, 32804, United States
Exelixis Clinical Site #61

Hamburg, 20249, Germany
Exelixis Clinical Site #62

Chiang Mai, 50200, Thailand
Exelixis Clinical Site #63

Hamburg, 22763, Germany
Exelixis Clinical Site #64

Woodville South, 5011, Australia
Exelixis Clinical Site #65

Jonesboro, Alabama, 72401, United States
Exelixis Clinical Site #66

Seoul, 05505, South Korea
Exelixis Clinical Site #67

Madrid, 28041, Spain
Exelixis Clinical Site #68

Opole, 45-061, Poland
Exelixis Clinical Site #69

Hamilton, 3204, New Zealand
Exelixis Clinical Site #7

New Orleans, Louisiana, 70112, United States
Exelixis Clinical Site #70

Tucson, Arizona, 85719, United States
Exelixis Clinical Site #71

Lyon, 69008, France
Exelixis Clinical Site #72

Madrid, 28034, Spain
Exelixis Clinical Site #73

Taichung, 40447, Taiwan
Exelixis Clinical Site #74

Charlotte, North Carolina, 28204, United States
Exelixis Clinical Site #75

Portland, Oregon, 97210, United States
Exelixis Clinical Site #76

Nashville, Tennessee, 37203, United States
Exelixis Clinical Site #77

Los Angeles, California, 90095, United States
Exelixis Clinical Site #78

Barcelona, 08023, Spain
Exelixis Clinical Site #79

Madrid, 28050, Spain
Exelixis Clinical Site #8

Billings, Montana, 59102, United States
Exelixis Clinical Site #80

Santa Monica, California, 90404, United States
Exelixis Clinical Site #81

Whittier, California, 90602, United States
Exelixis Clinical Site #82

Sylmar, California, 91342, United States
Exelixis Clinical Site #83

Albury, 2640, Australia
Exelixis Clinical Site #84

Dijon, 21079, France
Exelixis Clinical Site #85

Kaohsiung City, 807, Taiwan
Exelixis Clinical Site #86

Barcelona, 08035, Spain
Exelixis Clinical Site #87

Marseille, 13385, France
Exelixis Clinical Site #88

Herbault, 34298, France
Exelixis Clinical Site #89

Seattle, Washington, 98109, United States
Exelixis Clinical Site #9

Duarte, California, 91010, United States
Exelixis Clinical Site #90

Valencia, 46014, Spain
Exelixis Clinical Site #91

München, 81737, Germany
Exelixis Clinical Site #92

Hat Yai, 90110, Thailand
Exelixis Clinical Site #93

Suresnes, 92150, France
Exelixis Clinical Site #94

Singapore, 329563, Singapore
Exelixis Clinical Site #95

Lleida, 25198, Spain
Exelixis Clinical Site #96

Lisbon, 400-038, Portugal
Exelixis Clinical Site #97

Heidelberg, 3084, Australia
Exelixis Clinical Site #98

Singapore, 258499, Singapore
Exelixis Clinical Site #99

Guimarães, 4835-044, Portugal

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