New hope for Hard-to-Treat colorectal cancer: experimental drug combo enters human trials
NCT ID NCT06936527
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This study tests a new oral drug called XS-03 combined with standard chemotherapy and a targeted antibody (bevacizumab) in 102 people with metastatic colorectal cancer that has a RAS mutation. The goal is to see if the combination is safe and shrinks tumors better than current treatments. It is an early-phase trial, so the main focus is on safety and finding the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- XS-03 (oral drug) combined with chemotherapy (FOLFOX or FOLFIRI) and bevacizumab (injected antibody)
- What this could lead to
- If successful, this could offer a new treatment option for people with a hard-to-treat form of colorectal cancer, potentially improving tumor shrinkage and delaying progression.
- What could go wrong
- This is an early-phase trial (1b/2) with only 102 participants, so results may not apply broadly. The combination may cause significant side effects, and the added benefit of XS-03 is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beijing Cancer Hospital
Beijing, China
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