Blood test may spare thousands from unnecessary cancer surgery

NCT ID NCT06040632

Ongoing Knowledge-focused Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a blood test that detects tumor DNA can accurately identify patients who still have cancer after local removal of early-stage colorectal cancer. Currently, many patients undergo additional surgery even though about 85% are already cured by the initial procedure. If the blood test works, it could help doctors decide who truly needs more surgery and who can safely avoid it. The study involves 67 participants in Denmark.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: circulating tumor DNA (ctDNA) blood test
What this could lead to: If accurate, this blood test could help many patients avoid unnecessary follow-up surgery after early colorectal cancer removal.
What could go wrong: This is a small observational study (67 people) in Denmark, so results may not apply broadly. The test may not reliably detect all residual cancers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm polyp of large intestine

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER COLORECTAL CANCER STAGE I COLORECTAL POLYP

Contacts and locations

Locations

Aalborg University Hospital

Aalborg, North Denmark, 9000, Denmark
Aarhus University Hospital

Aarhus, Central Jutland, 8000, Denmark
Bispebjerg Hospital

Copenhagen, Capital Region of Denmark, 2400, Denmark
Gødstrup Hospital

Herning, Central Jutland, 7400, Denmark
Herlev Hospital

Herlev, Capital Region of Denmark, 2730, Denmark
Odense University Hospital

Odense, The Region of Southern Denmark, 5000, Denmark
Regional Hospital Horsens

Horsens, Central Jutland, 8700, Denmark
Regional Hospital Randers

Randers, Central Jutland, 8930, Denmark
Regional Hospital Viborg

Viborg, Central Jutland, 8800, Denmark

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