Could a simple antibiotic cocktail slash infection risk in colon cancer surgery?

NCT ID NCT07429760

ENROLLING_BY_INVITATION Disease control Sponsor: Shaukat Khanum Memorial Cancer Hospital & Research Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways of preparing the bowel before left-sided colorectal cancer surgery: standard mechanical bowel prep alone versus mechanical prep plus oral antibiotics (rifaximin and metronidazole). The goal is to see if adding antibiotics reduces surgical site infections within 30 days. Sixty adults scheduled for curative surgery are being enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rifampicin (also called Metronidazole) and Rifaximin
What this could lead to: If it works, this could show that adding oral antibiotics to standard bowel prep lowers the risk of surgical site infections after colorectal cancer surgery.
What could go wrong: This is a small, early-stage trial with only 60 participants, so results may not apply to all patients. The antibiotics may cause side effects or not reduce infections as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Shaukat Khanam Memorial Cancer Hospital & Research Centre Lahore

Lahore, Punjab Province, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.