Could a simple stool test replace colonoscopy for cancer screening in cystic fibrosis?

NCT ID NCT05362344

Ongoing Diagnosis Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether stool-based tests (like the FIT test and Cologuard) can accurately detect colorectal cancer and precancerous polyps in adults with cystic fibrosis. Researchers will compare these non-invasive tests to the standard colonoscopy in 350 participants. The goal is to find a simpler, less invasive screening option for this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Stool-based tests (FIT and DNA test)
What this could lead to: If successful, this could provide a non-invasive, easier screening option for colorectal cancer in people with cystic fibrosis.
What could go wrong: This is an observational study, not a treatment trial. Stool tests may miss some cancers or polyps, and colonoscopy remains the gold standard.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenoma colorectal cancer colorectal neoplasm cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOMA COLORECTAL CANCER CYSTIC FIBROSIS

Contacts and locations

Locations

Atrium Health Pulmonary Care

Charlotte, North Carolina, 28203, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Columbia University Medical Center

New York, New York, 10032, United States
Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Johns Hopkins Hospital, Johns Hopkins University

Baltimore, Maryland, 21287, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Michigan Medicine - University of Michigan

Ann Arbor, Michigan, 48109-5212, United States
National Jewish Health, University of Colorado

Denver, Colorado, 80206, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
North Carolina Children's Hospital / UNC

Chapel Hill, North Carolina, 27514, United States
Oregon Health & Science University

Portland, Oregon, 97239-3098, United States
Saint Louis University

St Louis, Missouri, 63103, United States
Stanford University Medical Center

Palo Alto, California, 94063, United States
University Hospitals Rainbow Babies & Children's

Cleveland, Ohio, 44106, United States
University of California, Los Angeles

Los Angeles, California, 90404, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Miami Hospital

Miami, Florida, 33136, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15219, United States
University of Texas Southwestern

Dallas, Texas, 75390, United States
University of Utah

Salt Lake City, Utah, 84132-4701, United States
University of Washington

Seattle, Washington, 98195, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Washington University

St Louis, Missouri, 63110, United States

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