Blood test may spot cancer return before symptoms appear

NCT ID NCT05210283

Ongoing Knowledge-focused Sponsor: Exact Sciences Corporation Source: ClinicalTrials.gov ↗

First seen Jan 12, 2026 · Last updated May 01, 2026 · Updated 10 times

Summary

This study looks at whether a blood test that finds tiny bits of tumor DNA (called ctDNA) can predict if colorectal cancer will return after surgery. About 1,000 people with stage II or III colorectal cancer who had their tumor removed will be followed for up to 7 years. The goal is to see if a positive ctDNA test is linked to cancer coming back, which could help doctors catch recurrence earlier.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Atrium Health Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
Ballad Health Cancer Center

Kingsport, Tennessee, 37660, United States
Columbus NCORP

Columbus, Ohio, 43215, United States
Cross Cancer Institute

Edmonton, Alberta, T6G1Z2, Canada
Edward Cancer Center

Elmhurst, Illinois, 60126, United States
Facey Medical Group - Mission Hills - Endoscopy Center & Gastroenterology

Mission Hills, California, 91345, United States
FirstHealth Outpatient Cancer Center

Pinehurst, North Carolina, 28374, United States
Illinois Cancer Care

Peoria, Illinois, 61615, United States
Interstate Medical Office Central

Portland, Oregon, 97227, United States
Jewish General Hospital

Montreal, Quebec, H3T1E2, Canada
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Marshfield Medical Center Weston

Weston, Wisconsin, 54476, United States
McGill University Health - Glen Site

Montreal, Quebec, H4A3J1, Canada
MedStar Georgetown Cancer Institute at MedStar Georgetown University Hospital

Baltimore, Maryland, 21237, United States
Mercy Medical Center

Cedar Rapids, Iowa, 52403, United States
Meritus Center for Clinical Research

Hagerstown, Maryland, 21742, United States
Metro Minnesota Community Oncology Consortium (MMCORC)

Saint Louis Park, Minnesota, 55426, United States
Mid Florida Cancer Centers

Orange City, Florida, 32763, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Mount Sinai Medical - Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States
Primsa Health Cancer Institute

Greenville, South Carolina, 29605, United States
Princess Margaret Cancer Center

Toronto, Ontario, M5G2C1, Canada
Reading Hospital Hematology Oncology

West Reading, Pennsylvania, 19611, United States
Sanford Cancer Center

Sioux Falls, South Dakota, 57104, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58104, United States
Torrance Memorial Hunt Cancer Institute

Torrance, California, 90505, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of Florida Division of Hematology & Oncology

Gainesville, Florida, 32610, United States
University of Kansas Cancer Center

Westwood, Kansas, 66205, United States
University of Maryland St. Joseph Medical Center

Towson, Maryland, 21093, United States
WellSpan York Cancer Center

York, Pennsylvania, 17403, United States

Conditions

Explore the condition pages connected to this study.

COLORECTAL CANCER