Blood test may spot hidden cancer DNA after surgery

NCT ID NCT05210283

Ongoing Knowledge-focused Sponsor: Exact Sciences Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a blood test that looks for tiny bits of cancer DNA in the blood after colorectal cancer surgery. The goal is to see if this test can predict whether the cancer will return. Over 1,000 people with stage II or III colorectal cancer will be followed for up to 7 years. The test is not a treatment, but a way to monitor for recurrence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ctDNA MRD test (blood test)
What this could lead to: If successful, this blood test could help doctors identify which patients are at risk of cancer returning after surgery, allowing for earlier treatment.
What could go wrong: This is a validation study, not a treatment trial. The test may not be accurate enough to change outcomes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Atrium Health Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
Ballad Health Cancer Center

Kingsport, Tennessee, 37660, United States
Columbus NCORP

Columbus, Ohio, 43215, United States
Cross Cancer Institute

Edmonton, Alberta, T6G1Z2, Canada
Edward Cancer Center

Elmhurst, Illinois, 60126, United States
Facey Medical Group - Mission Hills - Endoscopy Center & Gastroenterology

Mission Hills, California, 91345, United States
FirstHealth Outpatient Cancer Center

Pinehurst, North Carolina, 28374, United States
Illinois Cancer Care

Peoria, Illinois, 61615, United States
Interstate Medical Office Central

Portland, Oregon, 97227, United States
Jewish General Hospital

Montreal, Quebec, H3T1E2, Canada
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Marshfield Medical Center Weston

Weston, Wisconsin, 54476, United States
McGill University Health - Glen Site

Montreal, Quebec, H4A3J1, Canada
MedStar Georgetown Cancer Institute at MedStar Georgetown University Hospital

Baltimore, Maryland, 21237, United States
Mercy Medical Center

Cedar Rapids, Iowa, 52403, United States
Meritus Center for Clinical Research

Hagerstown, Maryland, 21742, United States
Metro Minnesota Community Oncology Consortium (MMCORC)

Saint Louis Park, Minnesota, 55426, United States
Mid Florida Cancer Centers

Orange City, Florida, 32763, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Mount Sinai Medical - Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States
Primsa Health Cancer Institute

Greenville, South Carolina, 29605, United States
Princess Margaret Cancer Center

Toronto, Ontario, M5G2C1, Canada
Reading Hospital Hematology Oncology

West Reading, Pennsylvania, 19611, United States
Sanford Cancer Center

Sioux Falls, South Dakota, 57104, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58104, United States
Torrance Memorial Hunt Cancer Institute

Torrance, California, 90505, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of Florida Division of Hematology & Oncology

Gainesville, Florida, 32610, United States
University of Kansas Cancer Center

Westwood, Kansas, 66205, United States
University of Maryland St. Joseph Medical Center

Towson, Maryland, 21093, United States
WellSpan York Cancer Center

York, Pennsylvania, 17403, United States

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