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Second chance: blood test guides retreatment for tough colorectal cancer

NCT ID NCT06578559

Ongoing Disease control Sponsor: Gruppo Oncologico del Nord-Ovest Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for people with a certain genetic type of advanced colorectal cancer (BRAF V600E) who previously benefited from a specific drug combination (encorafenib plus cetuximab). Researchers want to see if giving these drugs again, guided by a blood test that looks for cancer DNA, can shrink tumors. The study involves 16 participants and uses CT scans every 8 weeks to check results.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

  • A.O.U. Citta Della Salute E Della Scienza Di Torino Presidio Molinette

    Turin, TO, 10126, Italy

  • AUSL Romagna

    Ravenna, RA, 48121, Italy

  • Azienda Ospedaliera Universitaria degli Studi di Campania L. Vanvitelli

    Naples, 80131, Italy

  • Azienda Ospedaliero-Universitaria Pisana

    Pisa, PI, 56126, Italy

  • Azienda Sanitaria Universitaria Friuli Centrale

    Udine, UD, 33100, Italy

  • Fondazione Casa Sollievo Della Sofferenza - Irccs

    San Giovanni Rotondo, FG, 71013, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Roma, RM, 00168, Italy

  • IRCCS Istituto Nazionale dei Tumori di Milano

    Milan, MI, 20133, Italy

  • Istituto Oncologico Veneto Irccs

    Padova, PD, 35128, Italy

  • Istituto Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" Irccs Irst

    Meldola, FC, 47014, Italy

  • L'Azienda Ospedaliero Universitaria di Cagliari

    Monserrato, CA, 09042, Italy

  • Nuovo Ospedale di Prato S. STEFANO

    Prato, PO, 59100, Italy

  • Pia Fondazione di Culto e di Religione Cardinale G. Panico

    Tricase, LE, 73039, Italy

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