New combo treatment may slow colorectal cancer spread

NCT ID NCT05862051

Ongoing Disease control Sponsor: Australasian Gastro-Intestinal Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This trial is for people with colorectal cancer that has spread to a few spots in the body but cannot be fully removed by surgery alone. After 3-4 months of standard chemotherapy, participants either continue chemotherapy alone or also receive local ablative therapy—such as surgery, radiation, or heat/cold ablation—to target remaining tumors. The goal is to see if adding this local treatment helps delay the cancer from growing further.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Local ablative therapy (surgery, radiation, or heat/cold ablation)
What this could lead to: If successful, this approach could extend the time before colorectal cancer worsens, offering a new way to manage the disease.
What could go wrong: This is a very small early-phase trial with only 6 participants, so results may not apply broadly. The added procedures also carry risks like infection or side effects from radiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER OLIGOMETASTATIC DISEASE

Contacts and locations

Locations

Barwon Health

Geelong, Victoria, 3220, Australia
Bendigo Hospital

Bendigo, Victoria, 3550, Australia
Border Medical Oncology

Albury, New South Wales, 2640, Australia
Eastern Health

Box Hill, Victoria, 3128, Australia
Northeast Health Wangaratta

Wangaratta, Victoria, 3677, Australia
Peter MaCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
St Vincent's Hospital Melbourne

Fitzroy, Victoria, 3065, Australia
The Northern Hospital

Epping, Victoria, 3076, Australia
Western Health

Saint Albans, Victoria, 3021, Australia

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