New hope for Hard-to-Treat colorectal cancer: liquid biopsy guides smarter drug choice
NCT ID NCT04776655
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at people with advanced colorectal cancer whose tumor tissue shows no RAS/BRAF mutation, but a liquid biopsy (blood test) finds a RAS mutation. It compares two standard drug combos (FOLFIRI plus either cetuximab or bevacizumab) to see which works better at stopping the cancer from growing. About 280 adults will take part, and the goal is to find the best first treatment for this specific group.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AUSL/IRCCS di Reggio Emilia
RECRUITINGReggio Emilia, Reggio Emilia, 42123, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Azienda ULSS 3 Serenissima
RECRUITINGMirano, VE, 30035, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ospedale Civile di Guastalla
RECRUITINGGuastalla, Reggio Emilia, 42016, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ospedale San Salvatore
RECRUITINGCoppito, L'Aquila, 67100, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••