New hope for advanced colorectal cancer: study tests smarter drug switch based on blood test
NCT ID NCT04776655
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 27 times
Summary
This study is for people with advanced colorectal cancer that has a certain genetic makeup (RAS/BRAF wild type) in the tumor but shows a different genetic change (RAS mutation) in a blood test. The goal is to see if a combination of chemotherapy (FOLFIRI) plus a drug called bevacizumab works better than the standard combination of FOLFIRI plus cetuximab. About 280 participants will be randomly assigned to one of the two treatments to compare how long the cancer stays under control.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AUSL/IRCCS di Reggio Emilia
RECRUITINGReggio Emilia, Reggio Emilia, 42123, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Azienda ULSS 3 Serenissima
RECRUITINGMirano, VE, 30035, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ospedale Civile di Guastalla
RECRUITINGGuastalla, Reggio Emilia, 42016, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ospedale San Salvatore
RECRUITINGCoppito, L'Aquila, 67100, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.