New drug combo aims to tackle Hard-to-Treat colorectal cancer
NCT ID NCT05846867
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two immunotherapy drugs, AK119 and AK112, alone or with chemotherapy, in 170 people with a common type of colorectal cancer (pMMR/MSS). The goal is to see if these combinations shrink tumors and are safe. The trial is active but not recruiting new participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AK119 and AK112 (immunotherapy drugs) with or without chemotherapy (oxaliplatin, irinotecan, calcium folinate, fluorouracil)
What this could lead to
If successful, this could offer a new treatment option for people with a common type of colorectal cancer that is hard to treat.
What could go wrong
This is an early-phase trial (Phase Ib/II) with a small number of participants, so results may not apply to everyone. The drugs may cause side effects or not work better than existing treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cancer Hospital Affiliated to Harbin Medical University
Harbin, China