New combo therapy shows promise for Hard-to-Treat cancers

NCT ID NCT03697304

First seen Jan 27, 2026 · Last updated Jun 16, 2026 · Updated 19 times

Summary

This study tested a new immunotherapy drug, ezabenlimab, combined with other cancer medicines in 211 adults with advanced solid tumors that had spread. The goal was to see if the tumors shrank or disappeared. Participants received different drug combinations, and doctors monitored their health and side effects. The trial is complete, and results help guide future treatment options.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Beatson West of Scotland Cancer Centre

    Glasgow, G12 0YN, United Kingdom

  • Cross Cancer Institute (University of Alberta)

    Edmonton, Alberta, T6G 1Z2, Canada

  • Florida Cancer Specialists - East

    West Palm Beach, Florida, 33401, United States

  • Florida Cancer Specialists-Fort Myers-52980

    Fort Myers, Florida, 33901, United States

  • Florida Cancer Specialists-Saint Petersburg-52979

    St. Petersburg, Florida, 33705, United States

  • Florida Cancer Specialists-Sarasota-61670

    Tallahassee, Florida, 32308, United States

  • Guy's Hospital

    London, SE1 9RT, United Kingdom

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Medical College Of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Norton Cancer Institute

    Louisville, Kentucky, 40202, United States

  • Oklahoma University School of Community Medicine

    Oklahoma City, Oklahoma, 73104, United States

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 1Z6, Canada

  • Sarah Cannon Research Institute, London

    London, W1G 6AD, United Kingdom

  • Tennessee Oncology

    Chattanooga, Tennessee, 37404, United States

  • Tennessee Oncology, PLLC-Nashville-52568

    Nashville, Tennessee, 37203, United States

  • University College Hospital

    London, NW1 2BU, United Kingdom

  • University of California San Diego

    La Jolla, California, 92093, United States

Conditions

The condition(s) this trial relates to.

colorectal cancer endometrial carcinoma gastric adenocarcinoma gastroesophageal adenocarcinoma metastatic malignant neoplasm metastatic neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.