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New hope for Hard-to-Treat colon cancer? study tests targeted drug combo

NCT ID NCT05983367

Terminated Disease control Sponsor: Inspirna, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding the experimental drug ompenaclid to standard chemotherapy could shrink tumors in people with advanced colorectal cancer that has a RAS gene mutation. About 76 participants were randomly assigned to receive either ompenaclid or a placebo, along with the same chemotherapy. The study was terminated early, so results are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer colorectal neoplasm malignant colon neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER METASTATIC COLON CANCER

Contacts and locations

Locations

  • Antwerp University Hospital

    Antwerp, 2650, Belgium

  • CHU Hôpital Jean Minjoz

    Besançon, 25000, France

  • CHU Nantes -hopital hotel Dieu

    Nantes, Loire-Atlantique, 44093, France

  • CHU de Liège University hospital in Liège

    Liège, 4000, Belgium

  • Centre Georges-François Leclerc

    Dijon, 21000, France

  • Grand Hoptial De Charleroi

    Charleroi, 6000, Belgium

  • Groupe Hospitalier Paris Saint Joseph - Oncologie

    Paris, 75074, France

  • Hopital Prive des Cotes d'Armor

    Plérin, 22190, France

  • Hospital Clinico De Valencia

    Valencia, 46010, Spain

  • Hospital Clinico Universitario De Valencia

    Valencia, 46010, Spain

  • Hospital Puerta de Hierro Majadahonda

    Madrid, 28222, Spain

  • Hospital Puerta de Hierro Majadahonda

    Majadahonda, 28220, Spain

  • Hospital Universitari Vall D Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Reina Sofía

    Córdoba, 14004, Spain

  • Hospital Universitario Virgen de Valme

    Seville, 41014, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalonia, 08025, Spain

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Imelda Ziekenhuis

    Bonheiden, Antwerpen, 2820, Belgium

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Jules Bordet

    Anderlecht, Belgium

  • Institut Paoli-Calmettes

    Marseille, 13009, France

  • Institut de Cancerologie de l'Ouest

    Saint-Herblain, 44805, France

  • UZ Brussel

    Brussels, 1090, Belgium

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc

    Woluwe-Saint-Lambert, Brussels Capital, 1200, Belgium

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