New drug combo tested for Hard-to-Treat cancers

NCT ID NCT04989387

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This early-phase trial tested an experimental drug called INCA00186, alone or with other immunotherapy drugs, in people with advanced solid tumors such as head and neck or gastrointestinal cancers. The study aimed to find safe doses and check for early signs of effectiveness. It was terminated early, so full results may not be available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: INCA00186 (an experimental drug) given alone or with retifanlimab and/or INCB106385
What this could lead to: If it works, this could point toward a new treatment option for certain advanced solid tumors like head and neck or gastrointestinal cancers.
What could go wrong: This is a very early Phase 1 trial, so safety and effectiveness are not yet known. The study was terminated early, meaning results may be limited or inconclusive.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

anal canal squamous cell carcinoma colorectal cancer colorectal neoplasm digestive system cancer gastric cancer gastroesophageal junction adenocarcinoma head and neck squamous cell carcinoma hepatocellular carcinoma neoplasm pancreatic ductal adenocarcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS GASTROINTESTINAL (GI) MALIGNANCIES SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK (SCCHN)

Contacts and locations

Locations

Cambridge University Hospitals Nhs Foundation Trust

Cambridge, CB2 0QQ, United Kingdom
Carolina Bio-Oncology Institute, Pllc

Huntersville, North Carolina, 28078, United States
Cliniques Universitaires Ucl Saint-Luc

Brussels, 01200, Belgium
Emory University

Atlanta, Georgia, 30322, United States
Erasmus Mc Cancer Institute

Rotterdam, 3015GD, Netherlands
Freeman Hospital Newcastle Upon Tyne Foundation Nhs Trust

Newcastle upon Tyne, NE7 7DN, United Kingdom
Fundacion Jimenez Diaz University Hospital

Madrid, 28040, Spain
Ghent University Hospital

Ghent, 09000, Belgium
Guys and St Thomas Nhs Foundation Trust

London, SE1 9RT, United Kingdom
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hospital Clinico Universitario Virgen de La Victoria

Málaga, 29010, Spain
Hospital General Universitario Vall D Hebron

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Quironsalud Madrid

Pozuelo de Alarcón, 28223, Spain
Imperial College Healthcare Nhs Trust - Hammersmith Hospital

London, W12 0HS, United Kingdom
Innsbruck University Hospital

Innsbruck, A-6020, Austria
Institut Catala Doncologia Ico - Hospital Duran I Reynals Location

Barcelona, 199203, Spain
Institut Jules Bordet

Brussels, B-1070, Belgium
Landeskrankenhaus Salzburg

Salzburg, 05020, Austria
Md Anderson Cancer Center

Houston, Texas, 77030, United States
Netherlands Cancer Institute Antoni Van Leeuwenhoek Ziekenhuis

Amsterdam, 1066 CX, Netherlands
Radboud University Nijmegen Medical Center

Nijmegen, 6525 GA, Netherlands
South Texas Accelerated Research Therapeutics

San Antonio, Texas, 78229, United States
The Angeles Clinic and Research Institute

Los Angeles, California, 90025, United States
The Christie Nhs Foundation Trust Uk

Manchester, M20 4BV, United Kingdom
The Royal Marsden Nhs Foundation Trust - Chelsea

Sutton, SM2 5PT, United Kingdom
Universitair Ziekenhuis (Uz) Leuven

Leuven, 03000, Belgium
Universitair Ziekenhuis Antwerpen (Uza)

Edegem, 02650, Belgium
University Medical Center Groningen

Groningen, 9713GZ, Netherlands
University Medical Center Utrecht

Utrecht, 3584 CX, Netherlands
University of Maryland-Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
Vanderbilt Medical Center

Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.