Pfizer's new cancer pill tested in advanced tumors – study halted early

NCT ID NCT06704724

Terminated Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested a new cancer pill (PF-07985045) alone or with other drugs in people with advanced solid tumors that have a KRAS gene mutation. The trial included patients with lung, colon, or pancreatic cancer. The study aimed to check safety and find the right dose, but it was terminated early. Participants took the pill in 21- or 28-day cycles and could continue until their cancer stopped responding.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer colorectal neoplasm lung neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG CARCINOMA, PANCREATIC DUCTAL COLORECTAL NEOPLASMS

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
City of Hope (City of Hope National Medical Center, City Of Hope Medical Center)

Duarte, California, 91010, United States
Columbia University Irving Medical Center

New York, New York, 10032, United States
DFCI Chestnut Hill

Newton, Massachusetts, 02467, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Highlands Oncology Group

Fayetteville, Arkansas, 72703, United States
Highlands Oncology Group

Rogers, Arkansas, 72758, United States
Highlands Oncology Group

Springdale, Arkansas, 72762, United States
Pan American Center for Oncology Trials, LLC

Rio Piedras, 00935, Puerto Rico
The Trustees of Columbia University and The New York and Presbyterian Hospital

New York, New York, 10032, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States
University of Wisconsin Carbone Cancer Center-University Hospital

Madison, Wisconsin, 53792, United States

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