New drug trial offers hope for Hard-to-Treat cancers

NCT ID NCT05571839

Terminated Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This early-stage study tests a new drug, PF-08046049/SGN-BB228, in people with advanced melanoma and other solid tumors that have spread or stopped responding to standard treatments. The main goal is to check the drug's safety and find the best dose. About 41 participants will take part in three phases to see if the drug can help control these cancers.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm cutaneous melanoma malignant pancreatic neoplasm melanoma mesothelioma non-small cell lung carcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL NEOPLASMS CUTANEOUS MELANOMA MESOTHELIOMA NON-SMALL CELL LUNG CANCER PANCREATIC NEOPLASMS

Contacts and locations

Locations

Ambulatory Care Center at NYU Langone Medical Center

New York, New York, 10016, United States
BWH

Boston, Massachusetts, 02115, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Clinical Research Center Dermatology (CRCD) Dermatoonkologie Charité - Universitätsmedizin Berlin

Berlin, 10115, Germany
Clinical Research Center Dermatology (CRCD) Dermatoonkologie Charité - Universitätsmedizin Berlin

Berlin, 10117, Germany
Dana-Farber Cancer Institute (DFCI)

Boston, Massachusetts, 02215, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Insitut Gustave Roussy

Villejuif, Cedex, 94805, France
Insitut Gustave Roussy

Villejuif, 94805, France
Institut Gustave Roussy

Villejuif, 94805, France
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Laboratory Corporation of America

Raritan, New Jersey, 08869, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

New York, New York, 10016, United States
NYU Langone Hospitals, NYU Langone Rusk Ambulatory Surgical Pharmacy

New York, New York, 10016, United States
NYU Langone Medical Center(Tisch Hospital)

New York, New York, 10016, United States
Northwestern Medical Group

Chicago, Illinois, 60611, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
Presbyterian/St. Lukes Medical Center

Denver, Colorado, 80218, United States
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Quest Diagnostics Incorporated - Denver

Denver, Colorado, 80209, United States
Ronald Reagan UCLA Medical Center, Drug Information Center

Los Angeles, California, 90095, United States
Texas Oncology - Baylor Sammons Cancer Center

Dallas, Texas, 75251, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States
The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate

Los Angeles, California, 90025, United States
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate (Emergency Back-up only)

Santa Monica, California, 90404, United States
The Beatson West of Scotland Cancer Centre

Glasgow, Glasglow CITY, G12 0YN, United Kingdom
The Ottawa Hospital Cancer Centre

Ottawa, Ontario, K1H 8L6, Canada
UCLA Hematology - Oncology Clinic - Westlake Village

Westlake Village, California, 91361, United States
UCLA Hematology/ Oncology- Pasadena

Pasadena, California, 91105, United States
UCLA Hematology/Oncology

Los Angeles, California, 90095, United States
UCLA Hematology/Oncology - Administrative Office

Los Angeles, California, 90024, United States
UCLA Hematology/Oncology - Santa Barbara

Santa Barbara, California, 93101, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94143, United States
UCSF Medical Center, Investigational Pharmacy

San Francisco, California, 94158, United States
US Oncology Investigational Products Center (IPC)

Irving, Texas, 75063, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
UniversitätsSpital Zürich Dermatologische Klinik

Zurich, CH-8091, Switzerland

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