CUTANEOUS MELANOMA

This early-stage study tests a new medicine, PF-08046033, in adults with advanced lung, esophageal, or skin cancer that has spread or can't be removed. The main goals are to check safety, find the right dose, and see if it helps control the cancer. Participants receive the drug i…

This early-stage trial tests a new treatment combining two experimental therapies (IMA203 and mRNA-4203) for people with advanced melanoma or synovial sarcoma that has spread or can't be removed. The main goal is to check safety and find the best dose. About 15 participants will …

This study tests new combinations of immunotherapy drugs given before surgery to people with advanced melanoma that can be removed. The goal is to see if these combinations can reduce or eliminate the tumor before surgery, lowering the chance the cancer comes back. The trial is f…

This early-stage study tests a new drug called MBS8(1V270) in about 106 people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the best dose. Researchers will also look for early signs that the drug shrinks tumo…

This early-phase study tests a new drug called 177Lu-RAD204, which is a radioactive antibody that seeks out and attaches to a protein (PD-L1) on cancer cells. The goal is to see if it is safe and tolerable for people with advanced solid tumors like lung, breast, or skin cancer th…

This study tests a new oral drug, LNS8801, alone or with pembrolizumab, in people with advanced melanoma that has stopped responding to standard treatments. About 135 participants will be randomly assigned to one of three groups: LNS8801 alone, LNS8801 plus pembrolizumab, or stan…

This study tests a new drug called IDE196 in people with certain cancers that have specific gene mutations (GNAQ/11 or PRKC fusions), including metastatic uveal melanoma and colorectal cancer. The trial has two phases: first to find safe doses, then to see if the drug shrinks tum…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. It aims to see if these combinations can shrink brain tumors and how safe they are. About 33 adults whose melanoma has grown aft…

This study tests a new drug called AU-007 in people with advanced solid tumors (like melanoma or lung cancer) that cannot be removed by surgery or have spread. The drug is designed to help the immune system fight cancer more effectively. About 159 participants will receive AU-007…

This study is for people with high-risk melanoma who have had surgery to remove their cancer. It uses a special blood test to look for tiny bits of tumor DNA left in the body. If found, participants receive either a combination of two immunotherapy drugs or one drug alone to try …

This study tests whether EMLA numbing cream can reduce pain from Technetium 99 injections used in lymphoscintigraphy, a standard mapping procedure for skin cancers like melanoma. About 100 adults with skin cancer will receive either EMLA cream or a placebo before the injection. R…

This study follows 300 adults with stage IIB to IV melanoma who are receiving immune checkpoint inhibitors. Researchers will track 53 different symptoms over time to identify which are most common, severe, and distressing. The goal is to find risk factors linked to worse symptoms…

This study looks at how often a specific gene change (BAP1 mutation) is found in people with certain cancers like eye melanoma, skin melanoma, kidney cancer, and others. Researchers will study 500 patients and their family members to understand cancer patterns and risk factors. T…

This study looks at whether working outdoors in the sun increases the risk of melanoma, a type of skin cancer. Researchers in Modena, Italy, will interview 300 people (120 with melanoma and 180 without) about their job history, sun habits, and protection use. The goal is to bette…

This study looks at how things like mental health, social support, diet, and exercise affect the quality of life and health of people with melanoma. Researchers will survey up to 5,000 patients to understand these connections. The goal is to use this information to design future …