Personalized cell therapy takes on advanced melanoma in major trial

NCT ID NCT06743126

Recruiting now Disease control Sponsor: Immatics US, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests a one-time cell therapy called IMA203 for people with advanced melanoma that has not responded to prior treatment. IMA203 is made from a patient's own immune cells and is designed to target cancer cells. The study compares IMA203 to standard treatments like nivolumab plus relatlimab or lifileucel. About 360 participants will be enrolled to see if IMA203 improves survival and tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IMA203 (anzutresgene autoleucel), a personalized cell therapy made from the patient's own immune cells
What this could lead to: If successful, this could offer a new, one-time cell therapy option for people with advanced melanoma that has stopped responding to standard treatments.
What could go wrong: This is an early Phase 3 trial, so results are not guaranteed. Cell therapies can cause serious side effects, and the treatment may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma Melanoma, Cutaneous Malignant melanoma, cutaneous malignant, susceptibility to, 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA, CUTANEOUS MALIGNANT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Assistance Publique Hopitaux De Paris, Hôpital Saint Louis
NOT_YET_RECRUITING

Paris, 75010, France
Atlantic Health System/Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States
BC Cancer - Vancouver
ACTIVE_NOT_RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Baylor University
RECRUITING

Dallas, Texas, 75246, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Centre Hospitalier Universitaire De Lille
NOT_YET_RECRUITING

Lille, 59000, France
Charite Universitaetsmedizin Berlin KöR
RECRUITING

Berlin, 12203, Germany
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic, Taussig Cancer Institute
RECRUITING

Cleveland, Ohio, 44195, United States
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
NOT_YET_RECRUITING

Rotterdam, 3015 GD, Netherlands
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Goethe University Frankfurt
RECRUITING

Frankfurt am Main, 60590, Germany
Greater Glasgow and Clyde NHS, Beatson West of Scotland Cancer Center
NOT_YET_RECRUITING

Glasgow, G12 0YN, United Kingdom
Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
NOT_YET_RECRUITING

Amsterdam, 1066 CX, Netherlands
Honor Health Research Institute
RECRUITING

Scottsdale, Arizona, 85258, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94800, France
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Lehigh Valley Topper Cancer Institute
ACTIVE_NOT_RECRUITING

Allentown, Pennsylvania, 18103, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Oxford University Hospitals NHS Foundation Trust, Churchill Hospital
NOT_YET_RECRUITING

Oxford, OX3 7LE, United Kingdom
Providence Cancer Institute Franz Clinic
RECRUITING

Portland, Oregon, 97213, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Stanford Cancer Center
RECRUITING

Stanford, California, 94305, United States
Technische Universitaet Dresden
RECRUITING

Dresden, 01307, Germany
The Christie NHS Foundation Trust
NOT_YET_RECRUITING

Manchester, M20 4GJ, United Kingdom
The Royal Marsden NHS Foundation Trust
NOT_YET_RECRUITING

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Thomas Jeffersion University, Sidney Kimmel Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States
UCLA Hematology/Oncology
RECRUITING

Los Angeles, California, 90024, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94143, United States
UNC Hospitals, The University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Universitaet Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitaetsklinikum Bonn AöR
NOT_YET_RECRUITING

Bonn, 53127, Germany
Universitaetsklinikum Erlangen AöR
RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Essen AöR
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Heidelberg AöR
RECRUITING

Heidelberg, 69120, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
RECRUITING

Mainz, 55131, Germany
Universitair Medisch Centrum Groningen
NOT_YET_RECRUITING

Groningen, 9713 GZ, Netherlands
Universitatsklinikum Koeln
RECRUITING

Cologne, Northrhine-W Estphalia, 50937, Germany
University Health Network, Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University Medical Center Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado, Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of MD Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami - Sylvester Comprehensive Cancer Cente
RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Pennsylvania, Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
University of Southampton NHS Foundation Trust, Southampton General Hospital
NOT_YET_RECRUITING

Southampton, SO16 6YD, United Kingdom
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23219, United States
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

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