New drug targets rare genetic cancers in early trial
NCT ID NCT03947385
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called IDE196 in people with certain cancers that have specific genetic mutations (GNAQ/11 or PRKC fusions). The cancers include metastatic uveal melanoma, cutaneous melanoma, and colorectal cancer. The trial has two phases: first to find safe doses, then to see if the drug shrinks tumors. About 336 adults will take part.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COLORECTAL CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cancer Hematology Centers Western Michigan
ACTIVE_NOT_RECRUITINGGrand Rapids, Michigan, 49503, United States
-
Columbia University Medical Center - Herbert Irving Pavilion
ACTIVE_NOT_RECRUITINGNew York, New York, 10032, United States
-
Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
-
Princess Margaret Cancer Centre
ACTIVE_NOT_RECRUITINGToronto, Ontario, OPG 7-815, Canada
-
Queensland
ACTIVE_NOT_RECRUITINGWoolloongabba, 4102, Australia
-
SCRI - Denver
RECRUITINGDenver, Colorado, 80218, United States
-
San Francisco Oncology Associates
ACTIVE_NOT_RECRUITINGSan Francisco, California, 94115, United States
-
Sidney Kimmel Cancer Center at Thomas Jefferson University
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
-
The Cleveland Clinic Foundation
ACTIVE_NOT_RECRUITINGCleveland, Ohio, 44195, United States
-
The Sarah Cannon Research Institute/Tennessee Oncology
RECRUITINGNashville, Tennessee, 37203, United States
-
The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
-
UCLA Medical Center
RECRUITINGLos Angeles, California, 90095, United States
-
University of Cincinnati Cancer Center
RECRUITINGCincinnati, Ohio, 45267, United States
-
University of Iowa
ACTIVE_NOT_RECRUITINGIowa City, Iowa, 52242, United States
-
Westmead Hospital
ACTIVE_NOT_RECRUITINGSydney, New South Wales, Australia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a plasma beam stop colon polyps from coming back?
- A stitch in time: could a device make abdominal closure safer?
- Can we predict chemo brain before it happens?
- Your gut bacteria might reveal hidden cancer risk
- Can a smart digital program restore sleep for cancer survivors?
- Can a new infusion drug shrink Hard-to-Treat tumors?