BioNTech launches trial of BNT326 for advanced cancers

NCT ID NCT07070232

Recruiting now Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests a new drug called BNT326, given alone or with other cancer immunotherapies, in about 980 adults with advanced solid tumors that have spread or come back after prior treatment. The goal is to find the best dose and see if it is safe and effective. It is an early-stage trial, so results will help guide future research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BNT326 (a drug given by IV infusion)
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to other therapies.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants initially, so results may not apply broadly. Side effects are unknown and could be serious.

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Conditions

The condition(s) this trial relates to.

acral lentiginous melanoma cervical cancer colorectal cancer cutaneous melanoma gastric cancer gastric neoplasm gastroesophageal junction adenocarcinoma Her2-receptor negative breast cancer lethal congenital contracture syndrome 2 melanoma mucosal melanoma neoplasm non-small cell lung carcinoma uveal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ankara Bilkent City Hospital Phase 1 Clinical Research Cente
NOT_YET_RECRUITING

Ankara, 6800, Turkey (Türkiye)
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia
Brigitte Harris Cancer Pavilion BHCP
RECRUITING

Detroit, Michigan, 48202, United States
Cancer Research SA
RECRUITING

Adelaide, South Australia, 5000, Australia
Centre hospitalier universitaire de Liège
RECRUITING

Liège, 4000, Belgium
Centro Integral Oncologico Clara Campal
RECRUITING

Madrid, 28050, Spain
Charité - Campus Charité Mitte
NOT_YET_RECRUITING

Berlin, 10117, Germany
Cleveland Clinic Taussig Cancer Center
RECRUITING

Cleveland, Ohio, 44195, United States
Dana Farber Cancer Institute
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Dr. Abdurrahman Yurtaslan Ankara Oncology Traning & Research
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Duke Cancer Institute
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34232, United States
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Hacettepe Oncology Hospital
RECRUITING

Ankara, 6230, Turkey (Türkiye)
Hartford Healthcare
RECRUITING

Hartford, Connecticut, 06102, United States
Hospital Beata Maria Ana
RECRUITING

Madrid, 28007, Spain
Hospital Clinic de Barcelona
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Hospital Clinico San Carlos
NOT_YET_RECRUITING

Madrid, 28040, Spain
Hospital Universitari Vall d'Hebron - VHIO
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Hospital de San Pedro
RECRUITING

Logroño, 26006, Spain
IEO Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Imperial College London
RECRUITING

London, W12 0HS, United Kingdom
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, 80131, Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori
RECRUITING

Meldola, 47014, Italy
Klinikum der Universität München Campus Grosshadern
NOT_YET_RECRUITING

München, 81377, Germany
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02215, United States
Mayo Clinic Arizona
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
Melanoma Institute Australia
RECRUITING

Wollstonecraft, New South Wales, 2065, Australia
Memorial Sloan Kettering Hospital
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612-9497, United States
Northern Centre for Cancer Care
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
One Clinical Research Pty Ltd
RECRUITING

Nedlands, Western Australia, 6009, Australia
Peninsula and South Eastern Haematology & Oncology Group
NOT_YET_RECRUITING

Frankston, Victoria, 3199, Australia
Queen Elizabeth Hospital
RECRUITING

Birmingham, B15 2TH, United Kingdom
Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Marsden Hospital-London
RECRUITING

London, SW3 6JJ, United Kingdom
START Barcelona -HM Nou Delfos
RECRUITING

Barcelona, 8023, Spain
START Midwest, LLC
RECRUITING

Grand Rapids, Michigan, 49546, United States
START Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States
South Texas Accelerated Research Therapeutics (START), LLC
RECRUITING

San Antonio, Texas, 78229, United States
Southampton General Hospital
RECRUITING

Southampton, SO16 6YD, United Kingdom
St Vincent's Hospital Sydney
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Tasman Oncology Research Ltd
RECRUITING

Southport, Queensland, 4215, Australia
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Board of Regents of the University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792-6188, United States
The Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre
RECRUITING

Liverpool, L7 8YA, United Kingdom
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium
University College London Hospitals
RECRUITING

London, W1T 7HA, United Kingdom
University of California San Francisco
NOT_YET_RECRUITING

San Francisco, California, 94158, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Universitätsklinikum Tübingen
RECRUITING

Tübingen, 72076, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
RECRUITING

Mainz, 55131, Germany
Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Yale University
RECRUITING

New Haven, Connecticut, 06511, United States
Yeditepe University Kosuyolu Hospital
NOT_YET_RECRUITING

Istanbul, 34718, Turkey (Türkiye)
Ziekenhuis Aan de Stroom ZAS vzw
RECRUITING

Wilrijk, 2610, Belgium

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