Cancer combo trial halted early: what we learned

NCT ID NCT04612712

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a combination of two drugs, donafenib and KN046, in people with advanced gastrointestinal cancers that had not responded to standard treatments. The goal was to check safety and see if the drugs could shrink tumors. The trial was stopped early, and only 15 people took part.

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Conditions

The condition(s) this trial relates to.

colorectal cancer digestive system cancer digestive system carcinoma esophageal cancer gastric cancer hepatocellular carcinoma intrahepatic cholangiocarcinoma malignant pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Zhongshan Hospital Affiliated to Fudan University

    Shanghai, China