New immunotherapy combo aims to extend life in Tough-to-Treat colorectal cancer
NCT ID NCT07152821
First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 8 times
Summary
This Phase 3 trial is testing whether a combination of two immunotherapy drugs, botensilimab and balstilimab, can help people with advanced colorectal cancer that can't be removed by surgery and has stopped responding to chemotherapy. About 834 participants will receive either the drug combo or best supportive care. The main goal is to see if the drugs help people live longer, with additional focus on tumor shrinkage, quality of life, and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- botensilimab and balstilimab (immunotherapy drugs)
- What this could lead to
- If it works, this could offer a new treatment option for people with advanced colorectal cancer who have run out of standard therapies, potentially helping them live longer and have a better quality of life.
- What could go wrong
- This is a large Phase 3 trial, but immunotherapy doesn't work for everyone and can cause serious side effects. The cancer type studied (non-MSI-H) is typically less responsive to immunotherapy, so benefits may be modest or not seen at all.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kingston Health Science Centre
Kingston, Ontario, K0H1H0, Canada
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