New immunotherapy combo aims to extend life in Tough-to-Treat colorectal cancer
NCT ID NCT07152821
First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 4 times
Summary
This Phase 3 trial is testing whether a combination of two immunotherapy drugs, botensilimab and balstilimab, can help people with advanced colorectal cancer that can't be removed by surgery and has stopped responding to chemotherapy. About 834 participants will receive either the drug combo or best supportive care. The main goal is to see if the drugs help people live longer, with additional focus on tumor shrinkage, quality of life, and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
botensilimab and balstilimab (immunotherapy drugs)
What this could lead to
If it works, this could offer a new treatment option for people with advanced colorectal cancer who have run out of standard therapies, potentially helping them live longer and have a better quality of life.
What could go wrong
This is a large Phase 3 trial, but immunotherapy doesn't work for everyone and can cause serious side effects. The cancer type studied (non-MSI-H) is typically less responsive to immunotherapy, so benefits may be modest or not seen at all.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Allan Blair Cancer Centre
RECRUITINGRegina, Saskatchewan, S4T 7T1, Canada
Contact Phone: •••-•••-••••
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Arthur J.E. Child Comprehensive Cancer Centre
RECRUITINGCalgary, Alberta, T2N 5G2, Canada
Contact Phone: •••-•••-••••
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BCCA - Prince George
RECRUITINGPrince George, British Columbia, V2M 7E9, Canada
Contact
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BCCA - Vancouver
RECRUITINGVancouver, British Columbia, V5Z 4E6, Canada
Contact Phone: •••-•••-••••
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CHD de Vendée
NOT_YET_RECRUITINGLa Roche-sur-Yon, France
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CHU Dupuytren
NOT_YET_RECRUITINGLimoges, France
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CHU Estaing de Clermont-Ferrand
NOT_YET_RECRUITINGClermont-Ferrand, France
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CHU de Besançon
NOT_YET_RECRUITINGBesançon, France
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CHU de Bordeaux - Hôpital Haut Leveque
NOT_YET_RECRUITINGPessac, France
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CHU de Lille
NOT_YET_RECRUITINGLille, France
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CHU de Nantes
NOT_YET_RECRUITINGNantes, France
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CHU de Perpignan
NOT_YET_RECRUITINGPerpignan, France
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CHU de Poitiers
NOT_YET_RECRUITINGPoitiers, France
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CHU de Reims
NOT_YET_RECRUITINGReims, France
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CHU de Toulouse
NOT_YET_RECRUITINGToulouse, France
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CHUM-Centre Hospitalier de l'Universite de Montreal
RECRUITINGMontreal, Quebec, H2X 3E4, Canada
Contact Phone: •••-•••-••••
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CIUSSS de l'Est-de-I'lle-de-Montreal
NOT_YET_RECRUITINGMontreal, Quebec, H1T 2M4, Canada
Contact Phone: •••-•••-••••
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CIUSSS de l'Estrie - Centre hospitalier
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
Contact Phone: •••-•••-••••
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Centre Eugène Marquis
NOT_YET_RECRUITINGRennes, France
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Centre François Baclesse
NOT_YET_RECRUITINGCaen, France
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Centre Georges François Leclerc
NOT_YET_RECRUITINGDijon, France
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Centre Hospitalier Privé Saint Grégoire
NOT_YET_RECRUITINGSaint-Grégoire, France
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Centre Integre de Sante et de Services Sociaux
RECRUITINGGreenfield Park, Quebec, J4V 2H1, Canada
Contact Phone: •••-•••-••••
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Centre Jean Perrin
NOT_YET_RECRUITINGClermont-Ferrand, France
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Centre Léon Bérard
NOT_YET_RECRUITINGLyon, France
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Centre Paul Strauss
NOT_YET_RECRUITINGStrasbourg, France
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GH Diaconesses Croix Saint Simon
NOT_YET_RECRUITINGParis, France
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GH Mutualiste de Grenoble
NOT_YET_RECRUITINGGrenoble, France
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Gustave Roussy
NOT_YET_RECRUITINGVillejuif, France
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Hotel-Dieu de Quebec
RECRUITINGQuébec, Quebec, G1R 2J6, Canada
Contact Phone: •••-•••-••••
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Hôpital Européen Georges Pompidou
NOT_YET_RECRUITINGParis, France
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Hôpital Foch
NOT_YET_RECRUITINGSuresnes, France
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Hôpital Franco-Britannique - fondation Cognacq-Jay
NOT_YET_RECRUITINGLevallois-Perret, France
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Hôpital Privé Jean Mermoz
NOT_YET_RECRUITINGLyon, France
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Hôpital Privé du Confluent
NOT_YET_RECRUITINGNantes, France
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ICO Angers
NOT_YET_RECRUITINGAngers, France
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ICO Saint Herblain
NOT_YET_RECRUITINGSaint-Herblain, France
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Institut Bergonié
NOT_YET_RECRUITINGBordeaux, France
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Institut Paoli Calmettes
NOT_YET_RECRUITINGMarseille, France
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Institut Régional du Cancer de Montpellier
NOT_YET_RECRUITINGMontpellier, France
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Institut de Cancérologie de Lorraine
NOT_YET_RECRUITINGVandœuvre-lès-Nancy, France
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Institut du Cancer Avignon Sainte Catherine
NOT_YET_RECRUITINGAvignon, France
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Juravinski Cancer Centre at Hamilton Health Sciences
RECRUITINGHamilton, Ontario, L8V 5C2, Canada
Contact Phone: •••-•••-••••
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Kingston Health Sciences Centre
RECRUITINGKingston, Ontario, K7L 2V7, Canada
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Lakeridge Health Oshawa
RECRUITINGOshawa, Ontario, L1G 2B9, Canada
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London Health Sciences Centre Research Inc.
RECRUITINGLondon, Ontario, N6A 5W9, Canada
Contact Phone: •••-•••-••••
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Niagara Health System
RECRUITINGSt. Catharines, Ontario, L2S 0A9, Canada
Contact Phone: •••-•••-••••
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North York General Hospital
RECRUITINGToronto, Ontario, M2K 1E1, Canada
Contact Phone: •••-•••-••••
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Ottawa Hospital Research Institute
RECRUITINGOttawa, Ontario, K1H 8L6, Canada
Contact Phone: •••-•••-••••
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Saskatoon Cancer Centre
RECRUITINGSaskatoon, Saskatchewan, S7N 4H4, Canada
Contact Phone: •••-•••-••••
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Sinai Health System
RECRUITINGToronto, Ontario, M5G 1X5, Canada
Contact Phone: •••-•••-••••
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St. Michael's Hospital
RECRUITINGToronto, Ontario, M5B 1W8, Canada
Contact Phone: •••-•••-••••
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The Jewish General Hospital
RECRUITINGMontreal, Quebec, H3T 1E2, Canada
Contact Phone: •••-•••-••••
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University Health Network
RECRUITINGToronto, Ontario, M5G 2M9, Canada
Contact Phone: •••-•••-••••
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Waterloo Regional Health Network (WRHN)
RECRUITINGKitchener, Ontario, N2G 1G3, Canada
Contact Phone: •••-•••-••••