New 'Smart Bomb' radiation therapy targets multiple cancers in early trial

NCT ID NCT06562192

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 30, 2026 · Updated 5 times

Summary

This early-stage trial is testing a new type of targeted radiation therapy for people with advanced pancreatic, lung, breast, or colorectal cancers. The treatment uses a radioactive drug that seeks out cancer cells to deliver radiation directly, aiming to kill them while sparing healthy tissue. The study will enroll 162 adults to check safety, find the right dose, and get a first look at whether it shrinks tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radioligand therapy ([177Lu]Lu-NNS309) and imaging agent ([68Ga]Ga-NNS309)
What this could lead to: If successful, this could lead to a new targeted radiation treatment for several hard-to-treat cancers, potentially shrinking tumors with fewer side effects than traditional chemotherapy.
What could go wrong: This is a very early Phase 1 trial, so the main goal is safety, not effectiveness. The therapy may not work, could cause serious side effects, and is only tested in a small number of people.

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Conditions

The condition(s) this trial relates to.

breast neoplasm colorectal cancer colorectal neoplasm hormone receptor-positive breast cancer non-small cell lung carcinoma pancreatic ductal adenocarcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER HR+/HER2- DUCTAL AND LOBULAR BREAST CANCER NON-SMALL CELL LUNG CANCER PANCREATIC DUCTAL ADENOCARCINOMA TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

BAMF Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Novartis Investigative Site
RECRUITING

Brussels, 1000, Belgium
Novartis Investigative Site
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H2X 1R9, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Novartis Investigative Site
RECRUITING

Bron, 69677, France
Novartis Investigative Site
RECRUITING

Villejuif, 94800, France
Novartis Investigative Site
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
Novartis Investigative Site
RECRUITING

Essen, 45147, Germany
Novartis Investigative Site
RECRUITING

München, 80377, Germany
Novartis Investigative Site
RECRUITING

Rostock, 18057, Germany
Novartis Investigative Site
RECRUITING

Tel Aviv, 6423906, Israel
Novartis Investigative Site
RECRUITING

Milan, MI, 20133, Italy
Novartis Investigative Site
RECRUITING

Reggio Emilia, RE, 42123, Italy
Novartis Investigative Site
RECRUITING

Nijmegen, Gelderland, 6500HB, Netherlands
Novartis Investigative Site
RECRUITING

Utrecht, 3584 CX, Netherlands
Novartis Investigative Site
RECRUITING

Barcelona, 08036, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28009, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28040, Spain
Novartis Investigative Site
RECRUITING

Geneva, 1211, Switzerland
Novartis Investigative Site
RECRUITING

Lausanne, 1011, Switzerland
Stanford University Medical Center
RECRUITING

Palo Alto, California, 94304, United States
Uni Of TX MD Anderson Cancer Cntr
RECRUITING

Houston, Texas, 77030, United States
Uni of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35249, United States
University Of Washington
RECRUITING

Seattle, Washington, 98109, United States
University of California LA
RECRUITING

Los Angeles, California, 90095, United States

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