New combo therapy aims to tackle colorectal cancer liver spread

NCT ID NCT06848465

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing whether adding low-dose radiation to standard immunotherapy and chemotherapy is safe for people with colorectal cancer that has spread only to the liver. About 9 to 18 participants will receive the combination treatment. The main goal is to check for side effects and see if the approach is feasible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Low-dose radiotherapy, tislelizumab (immunotherapy), oxaliplatin and capecitabine (chemotherapy)

What this could lead to

If this combination proves safe and feasible, it could point toward a new treatment option for colorectal cancer that has spread only to the liver.

What could go wrong

This is a very early phase 1 trial with only 9-18 participants, so the main goal is safety, not effectiveness. The combination may cause significant side effects and might not shrink tumors.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm Lhermitte-Duclos disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Army Medical Center

    RECRUITING

    Chongqing, Chongqing Municipality, 400042, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Daping Hospital, Army Medical University

    ACTIVE_NOT_RECRUITING

    Chongqing, Chongqing Municipality, 400042, China