Immunotherapy boost for hard-to-treat bowel cancer?
NCT ID NCT06733038
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (FOLFOXIRI) and bevacizumab helps people with a specific type of metastatic colorectal cancer live longer without their disease getting worse. The study enrolls 238 adults whose tumors have a certain immune profile (Immunoscore IC-high) and are not mismatch repair deficient. The main goal is to see if the combination delays cancer progression compared to chemotherapy alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
atezolizumab (an immunotherapy drug) added to standard chemotherapy (FOLFOXIRI) and bevacizumab
What this could lead to
If successful, this could offer a new first-line treatment option that delays cancer progression for people with a specific type of metastatic colorectal cancer.
What could go wrong
This is a Phase 3 trial, but it only includes patients with a specific immune profile (Immunoscore IC-high). Adding immunotherapy may increase side effects, and it is not yet known if it will meaningfully improve survival.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AOU Careggi
RECRUITINGFlorence, FI, 50134, Italy
Contact Email: •••••@•••••
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ASL di Viterbo
RECRUITINGViterbo, VT, 01100, Italy
Contact Email: •••••@•••••
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Azienda Ospedaliera Card. G. Panico
RECRUITINGTricase, LE, 73039, Italy
Contact Email: •••••@•••••
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Azienda Ospedaliera Universitaria Luigi Vanvitelli
RECRUITINGNaples, 80131, Italy
Contact Email: •••••@•••••
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Azienda Ospedaliero Universitaria Policlinico Rodolico - S. Marco
RECRUITINGCatania, CT, 95123, Italy
Contact Email: •••••@•••••
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Azienda Ospedaliero Universitaria di Modena
RECRUITINGModena, MO, 41124, Italy
Contact Email: •••••@•••••
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Azienda Sanitaria Universitaria Friuli Centrale
RECRUITINGUdine, UD, 33100, Italy
Contact Email: •••••@•••••
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Azienda USL Toscana Nord Ovest
RECRUITINGLivorno, LI, 57124, Italy
Contact Email: •••••@•••••
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Azienda USL della Romagna
RECRUITINGRavenna, RA, 48121, Italy
Contact Email: •••••@•••••
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Azienda Usl di Piacenza
RECRUITINGPiacenza, 29121, Italy
Contact Email: •••••@•••••
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Fondazione Casa Sollievo della Sofferenza
RECRUITINGSan Giovanni Rotondo, FG, 71013, Italy
Contact Email: •••••@•••••
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
RECRUITINGMilan, MI, 20122, Italy
Contact Email: •••••@•••••
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Fondazione IRCCS INT - Milano
RECRUITINGMilan, MI, 20133, Italy
Contact Email: •••••@•••••
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Fondazione Poliambulanza, Istituto Ospedaliero
RECRUITINGBrescia, BS, 25124, Italy
Contact Email: •••••@•••••
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITINGRoma, RM, 00168, Italy
Contact Email: •••••@•••••
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IRCCS Centro di Riferimento Oncologico
RECRUITINGAviano, PN, 33081, Italy
Contact Email: •••••@•••••
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IRCCS Istituto Nazionale Tumori "Fondazione Giovanni Pascale"
RECRUITINGNaples, 80131, Italy
Contact Email: •••••@•••••
Contact
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Istituto Oncologico Veneto Irccs
RECRUITINGPadova, PD, 35128, Italy
Contact Email: •••••@•••••
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Istituto Romagnolo per lo Studio dei Tumori Dino Amadori
RECRUITINGMeldola, FC, 47014, Italy
Contact Email: •••••@•••••
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Nuovo Ospedale di Prato S. Stefano
RECRUITINGPrato, PO, 59100, Italy
Contact Email: •••••@•••••
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Ospedale San Luca
RECRUITINGLucca, LU, 55100, Italy
Contact Email: •••••@•••••
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Ospedale San Raffaele
RECRUITINGMilan, MI, 20132, Italy
Contact Email: •••••@•••••
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Policlinico Universitario Tor Vergata
RECRUITINGRome, 00133, Italy
Contact Email: •••••@•••••
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U.O. Oncologia Medica 2 Universitaria - Azienda Ospedaliero-Universitaria Pisana Dipartimento di Ricerca Traslazionale e Nuove Tecnologie - University of Pisa
RECRUITINGPisa, 56126, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••