New drug cocktail shows promise in shrinking tough colon tumors before surgery
NCT ID NCT05706779
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study is testing whether giving two drugs (encorafenib and cetuximab) before surgery can shrink tumors in people with a specific genetic mutation (BRAF V600E) in colon or upper rectal cancer. About 30 participants will receive the drugs for 6 weeks before their planned surgery. The main goal is to see how many tumors shrink significantly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
encorafenib and cetuximab
What this could lead to
If successful, this approach could shrink tumors before surgery, potentially improving outcomes for people with this specific type of colon cancer.
What could go wrong
This is a small, early-phase trial with only 30 participants. It may not work for everyone, and side effects from the drug combination are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Chu - Hôpital Européen Georges Pompidou
RECRUITINGParis, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact