New cancer drug combo enters first human tests

NCT ID NCT06804824

Recruiting now Disease control Sponsor: Vividion Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a new drug called VVD-159642, which targets specific cancer-driving proteins. It is given alone or with other drugs (sotorasib or trametinib) to people with advanced solid tumors that have certain genetic changes. The main goals are to check safety, find the right dose, and see if it shrinks tumors. About 220 participants will take part across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VVD-159642 (a targeted drug that blocks cancer growth signals), sotorasib, and trametinib
What this could lead to: If successful, this could lead to a new treatment option for people with advanced solid tumors that have specific genetic changes.
What could go wrong: This is a very early, first-in-human trial, so safety and effectiveness are not yet known. The drug may not work or could cause serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

Clinical Research South Australia (CRSA)
RECRUITING

Adelaide, South Australia, 5000, Australia
Linear Clinical
RECRUITING

Nedlands, Western Australia, 6009, Australia
NEXT Austin
RECRUITING

Austin, Texas, 78758, United States
NEXT Dallas
RECRUITING

Irving, Texas, 75039, United States
NEXT San Antonio
RECRUITING

San Antonio, Texas, 78299, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
START Mid West
RECRUITING

Grand Rapids, Michigan, 49546, United States
START Mountain
RECRUITING

Ogden, Utah, 84401, United States
START San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

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