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Can a simple blood test replace colonoscopy for cancer screening?

NCT ID NCT07090291

Recruiting now Diagnosis Sponsor: Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares three ways to screen for colorectal cancer in average-risk people aged 45-74: colonoscopy, a stool test (FIT), and a stool test plus a blood test. Over 60,000 participants will be randomly assigned to one of the three methods. The goal is to see if the simpler tests are as good as colonoscopy at reducing deaths from colorectal cancer over 10 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could show that simpler, non-invasive tests like FIT or a blood test are as effective as colonoscopy for screening, potentially making screening easier and more accessible.
What could go wrong
This is a large trial but results won't be available for 10 years. The blood test is still experimental, and it may not prove as accurate or effective as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal neoplasm colorectal adenoma prevention target colorectal cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED ADENOMA COLORECTAL CANCER

Contacts and locations

Locations

  • Maoming People's Hospital

    RECRUITING

    Guangdong, China

  • Nanjing Medical University

    RECRUITING

    Nanjing, China

  • Shanghai Municipal Center For Disease Control & Prevention

    RECRUITING

    Shanghai, China

  • Sichuan Cancer Hospital & Institute, Sichuan Cancer Center

    RECRUITING

    Sichuan, China

  • Sun Yat-sen University Cancer Center

    RECRUITING

    Guandong, China

  • The Fourth Hospital of Hebei Medical University

    RECRUITING

    Hebei, China

  • Zhejiang Provincial Center for Disease Control and Prevention

    RECRUITING

    Zhejiang, China

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