New pill targets stubborn colorectal cancer mutation

NCT ID NCT07659795

Recruiting now Disease control Sponsor: Verastem, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 9 times

Summary

This study tests an experimental pill called VS-7375, designed to block a specific cancer-driving protein (KRAS G12D). The trial includes people with metastatic colorectal cancer that has this mutation. Some participants receive VS-7375 alone, others get it combined with an antibody therapy or with antibody therapy plus chemotherapy. The goal is to see if these combinations can shrink tumors and control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VS-7375
What this could lead to: If successful, this could provide a new targeted treatment option for people with a hard-to-treat form of colorectal cancer that has spread.
What could go wrong: This is an early-phase trial with a small number of participants, so the drug may not work as hoped or could cause significant side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Icon Cancer Centre Adelaide
RECRUITING

Kurralta Park, South Australia, 5037, Australia
Icon Cancer Centre South Brisbane
RECRUITING

South Brisbane, Queensland, 4101, Australia
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
START Dallas Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
START Los Angeles
RECRUITING

Los Angeles, California, 90025, United States
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
START Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States
START New Jersey
RECRUITING

East Brunswick, New Jersey, 08816, United States
UVA Comprehensive Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States
Valkyrie Clinical Trials (contact for more locations)
RECRUITING

Los Angeles, California, 90067, United States

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