Could skipping opioids during surgery help fight colorectal cancer?

NCT ID NCT07264556

Recruiting now Knowledge-focused Sponsor: Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares three types of anesthesia during colorectal cancer surgery: opioid-based, opioid-sparing, and opioid-free. Researchers will measure immune markers called NETs in the blood and test how the blood affects cancer cells in the lab. The goal is to see if avoiding opioids might reduce cancer spread and improve recovery. 90 adults undergoing elective surgery are being recruited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: opioid-free anesthesia (esketamine, lidocaine, dexmedetomidine) and opioid-sparing anesthesia (oxycodone, TAP block) compared to standard opioid-based anesthesia
What this could lead to: If successful, this could show that using less or no opioids during surgery might reduce cancer spread risk and improve recovery.
What could go wrong: This is a small, early-stage study (90 people) looking at blood markers, not long-term outcomes. The results may not change practice or apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoid tumor colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER NETS OPIOID-FREE ANESTHESIA

Contacts and locations

Locations

Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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