Lab-Grown tumor avatars could pick the right cancer drug for each patient

NCT ID NCT06077591

Recruiting now Knowledge-focused Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a personalized approach for patients with advanced liver or colorectal cancers that no longer respond to standard treatments. Doctors take a small sample of the tumor, grow it in the lab as 3D 'organoids', and test different drugs on them to see which works best. The goal is to see if this method can improve tumor shrinkage and survival compared to usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Patient-derived tumor organoid (PDO) drug screening and next-generation sequencing (NGS) to guide treatment selection
What this could lead to: If successful, this approach could provide a new way to select effective treatments for patients with advanced cancers who have run out of standard options.
What could go wrong: This is a small, early-phase study with only 40 participants. The organoid culture may fail for some patients, and the drug screen results may not always match real-world response.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm hepatocellular carcinoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER HEPATOCELLULAR CARCINOMA

Contacts and locations

Locations

Endoscopy Centre, Prince of Wales Hospital
RECRUITING

Hong Kong, N.T., 123, Hong Kong

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