New hope for lung cancer patients: targeted drug Dato-DXd faces off against chemo

NCT ID NCT07291037

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 02, 2026 · Updated 4 times

Summary

This phase 3 trial compares a new targeted drug, datopotamab deruxtecan (Dato-DXd), against the standard chemotherapy docetaxel in 400 people with advanced or metastatic non-squamous non-small cell lung cancer that lacks certain gene mutations. The goal is to see if Dato-DXd can slow cancer growth and improve survival. Participants must have TROP2-positive tumors and have received prior treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: datopotamab deruxtecan (Dato-DXd)
What this could lead to: If it works, this could offer a more effective treatment option for people with advanced lung cancer who have limited choices.
What could go wrong: This is an early-stage comparison; the new drug may not prove better than the standard chemo and could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER (NSCLC)

Contacts and locations

Locations

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Chandler, Arizona, 85224, United States
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Gilbert, Arizona, 85234, United States
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Goodyear, Arizona, 85338, United States
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Duarte, California, 91010, United States
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Irvine, California, 92618, United States
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La Jolla, California, 92093, United States
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Loma Linda, California, 92350, United States
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Los Angeles, California, 90095, United States
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San Diego, California, 92123, United States
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Grand Junction, Colorado, 81501, United States
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Wheat Ridge, Colorado, 80033, United States
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Newark, Delaware, 19713, United States
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Washington D.C., District of Columbia, 20037, United States
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Fort Myers, Florida, 33901, United States
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Jacksonville, Florida, 32224, United States
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St. Petersburg, Florida, 33709, United States
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Tampa, Florida, 33612, United States
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West Palm Beach, Florida, 33401, United States
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Marietta, Georgia, 30060, United States
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Newnan, Georgia, 30265, United States
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Chicago, Illinois, 60612, United States
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Chicago, Illinois, 60637, United States
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Niles, Illinois, 60714, United States
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Zion, Illinois, 60099, United States
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Louisville, Kentucky, 40207, United States
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South Portland, Maine, 04106, United States
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Baltimore, Maryland, 21201, United States
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Brandywine, Maryland, 20613, United States
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Boston, Massachusetts, 02215, United States
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Detroit, Michigan, 48202, United States
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Rochester, Minnesota, 55905, United States
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Bridgeton, Missouri, 63044, United States
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Columbia, Missouri, 65212, United States
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Lincoln, Nebraska, 68516, United States
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Albuquerque, New Mexico, 87109, United States
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East Syracuse, New York, 13057, United States
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Portland, Oregon, 97239, United States
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Hershey, Pennsylvania, 17033, United States
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Lancaster, Pennsylvania, 17601, United States
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Greenville, South Carolina, 29607, United States
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Memphis, Tennessee, 38120, United States
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Austin, Texas, 78745, United States
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Denton, Texas, 76201, United States
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Plano, Texas, 75075, United States
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Charlottesville, Virginia, 22908, United States
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Fairfax, Virginia, 22031, United States
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Williamsburg, Virginia, 23188, United States
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Tacoma, Washington, 98405, United States
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Morgantown, West Virginia, 26506, United States
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Eau Claire, Wisconsin, 54703, United States
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Gosford, 2250, Australia
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Kogarah, 2217, Australia
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South Brisbane, 4101, Australia
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St Albans, 3021, Australia
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Wollongong, 2500, Australia
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Graz, 8036, Austria
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Linz, 4021, Austria
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Rankweil, 6830, Austria
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Vienna, 1140, Austria
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Vienna, 1210, Austria
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Hasselt, 3500, Belgium
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La Louvière, 7100, Belgium
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Libramont-Chevigny, 6800, Belgium
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Sint-Niklaas, 9100, Belgium
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Yvoir, 5530, Belgium
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Porto Alegre, 90610-000, Brazil
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Porto Alegre, 91350-200, Brazil
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Salvador, 40170-110, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 05652-900, Brazil
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Vancouver, British Columbia, VSZ 4E6, Canada
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Moncton, New Brunswick, E1C 6Z8, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Hamilton, Ontario, L8V 1C3, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Beijing, 100034, China
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Beijing, 100142, China
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Beijing, 101149, China
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Changchun, 130000, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chongqing, 400030, China
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Fuzhou, 350011, China
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Guangzhou, 510080, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230610, China
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Jiamusi, 154007, China
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Jinan, 250117, China
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Nanchang, 330006, China
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Nanjing, 2100008, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Shanghai, 200433, China
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Shantou, 515041, China
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Shenyang, 110004, China
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Tianjin, 300050, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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Xuzhou, 221009, China
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Zhengzhou, 450008, China
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Zhengzhou, 450052, China
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Boulogne-Billancourt, 92104, France
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Lyon, 69008, France
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Marseille, 13915, France
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Saint-Herblain, 44800, France
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Toulouse, 31400, France
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Bad Saarow, 15526, Germany
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Bielefeld, 33611, Germany
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Bonn, 53127, Germany
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Cologne, 51109, Germany
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Essen, 45147, Germany
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Frankfurt, 60488, Germany
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Freiburg im Breisgau, 79106, Germany
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Gauting, 82131, Germany
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Hamburg, 20251, Germany
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Heidelberg, 69126, Germany
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Krefeld, 47805, Germany
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Minden, 32429, Germany
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Oldenburg, 26121, Germany
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Stuttgart, 70174, Germany
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Troisdorf, 53840, Germany
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Velbert, 42551, Germany
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Budapest, 1083, Hungary
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Budapest, 1121, Hungary
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Budapest, 1122, Hungary
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Budapest, 1145, Hungary
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Debrecen, 4032, Hungary
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Gyöngyös - Mátraháza, 3200, Hungary
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Győr, 9024, Hungary
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Gyula, 5700, Hungary
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Kecskemét, 6000, Hungary
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Szolnok, 5000, Hungary
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Törökbálint, 2045, Hungary
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Bangalore, 560027, India
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Kolkata, 700016, India
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Mumbai, 400012, India
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Nashik, 422011, India
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New Delhi, 11029, India
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Milan, 20141, Italy
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Milan, 20162, Italy
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Monza, 20052, Italy
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Orbassano, 10043, Italy
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Padova, 35128, Italy
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Rozzano, 20089, Italy
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Hiroshima, 734-8551, Japan
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Iwakuni-shi, 740-8510, Japan
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Kashiwa, 277-8577, Japan
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Kawasaki-shi, 216-8511, Japan
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Kyoto, 612-8555, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Osakasayama-shi, 589-8511, Japan
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Sendai, 981-0914, Japan
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Sunto-gun, 411-8777, Japan
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Yokohama, 241-8515, Japan
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Lodz, 93-338, Poland
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Olsztyn, 10-357, Poland
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Poznan, 60-569, Poland
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Warsaw, 02-781, Poland
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Goyang-si, 10408, South Korea
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Incheon, 21565, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 5505, South Korea
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Suwon, 16247, South Korea
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A Coruña, 15009, Spain
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Barcelona, 8035, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Seville, 41009, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 80756, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 73657, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 11490, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10300, Thailand
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Muang, 50200, Thailand
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Ankara, 06530, Turkey (Türkiye)
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Istanbul, 32098, Turkey (Türkiye)
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Huddersfield, HD3 3EA, United Kingdom
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London, SE1 9RT, United Kingdom
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London, SW10 9NH, United Kingdom
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London, SW170QT, United Kingdom
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Maidstone, ME16 9QQ, United Kingdom
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Norwich, NR4 7UY, United Kingdom
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Stoke-on-Trent, ST4 6QG, United Kingdom
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 70 449, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Vinh, 460000, Vietnam

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